Listar por tema "ketonucleosides"

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Exomethylene pyranonucleosides: Efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-D-glycero-hex-3-enopyranosyl)thymine

Agelis, G.; Tzioumaki, N.; Boti, T.; Cencic, A. A.; Komiotis, D. (2007)

A new series of unsaturated pyranonucleosides with an exocyclic methylene group and thymine as heterocyclic base have been designed and synthesized. D-Galactose (1) was readily transformed in three steps into the corresponding ...
Keto and Exomethylene Pyranonucleosides as Antitumor Agents

Tsoukala, E.; Manta, S.; Kiritsis, C.; Komiotis, D. (2012)

Nucleosides and their analogues take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. Recently, there has been a renewed interest in the synthesis of keto and ...
Synthesis and molecular modelling of unsaturated exomethylene pyranonucleoside analogues with antitumor and antiviral activities

Agelis, G.; Tzioumaki, N.; Tselios, T.; Botic, T.; Cencic, A.; Komiotis, D. (2008)

This report describes the total and facile synthesis of the unsaturated keto and exomethylene pyranonucleoside analogues, 1-(2,3,4-trideoxy-4-methylene-6-O-trityl-alpha-D-glycero-hex-2-enopyranosyl)uracil (10), ...