Listar por tema "angiotensin converting enzyme 2"

The Comparative Superiority of SARS-CoV-2 Antibody Response in Different Immunization Scenarios

Kotsiou O.S., Karakousis N., Papagiannis D., Matsiatsiou E., Avgeri D., Fradelos E.C., Siachpazidou D.I., Perlepe G., Miziou A., Kyritsis A., Gogou E., Vavougios G.D., Kalantzis G., Gourgoulianis K.I. (2022)

Background: Both SARS-CoV-2 infection and/or vaccination result in the production of SARS-CoV-2 antibodies. We aimed to compare the antibody titers against SARS-CoV-2 in different scenarios for antibody production. Methods: ...

COVID-19 and human reproduction: A pandemic that packs a serious punch

Anifandis G., Tempest H.G., Oliva R., Swanson G.M., Simopoulou M., Easley C.A., Primig M., Messini C.I., Turek P.J., Sutovsky P., Ory S.J., Krawetz S.A. (2021)

The COVID-19 pandemic has led to a worldwide health emergency that has impacted 188 countries at last count. The rapid community transmission and relatively high mortality rates with COVID-19 in modern times are relatively ...

COVID-19 and the cardiovascular system-current knowledge and future perspectives

Chatzis D.G., Magounaki K., Pantazopoulos I., Bhaskar S.M.M. (2022)

The current coronavirus disease 2019 (COVID-19) pandemic has had devastating impact on populations around the world. The high mortality rates in patients with COVID-19 has been attributed to the influence of severe acute ...

COVID-19 immunopathology and the central nervous system: Implication for multiple sclerosis and other autoimmune diseases with associated demyelination

Boziki M.K., Mentis A.-F.A., Shumilina M., Makshakov G., Evdoshenko E., Grigoriadis N. (2020)

In the frame of the coronavirus disease 2019 (COVID-19) pandemic, recent reports on SARS-CoV-2 potential neuroinvasion placed neurologists on increased alertness in order to assess early neurological manifestations and ...

COVID-19 pandemic and cardiovascular disease: where do we stand?

Chatzis D.G., Magounaki K.T., Pantazopoulos I.N., Johnson E.O., Tsioufis K.P. (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19) which recently has been characterized as a pandemic by the World Health Organization (WHO) having killed ...

The current evidence regarding covid‐19 and pregnancy: Where are we now and where should we head to next?

Kalampokas T., Rapani A., Papageorgiou M., Grigoriadis S., Maziotis E., Anifandis G., Triantafyllidou O., Tzanakaki D., Neofytou S., Bakas P., Simopoulou M., Vlahos N. (2021)

Despite the volume of publications dedicated to unraveling the biological characteristics and clinical manifestations of SARS‐CoV‐2, available data on pregnant patients are limited. In the current review of literature, we ...

A data-driven hypothesis on the epigenetic dysregulation of host metabolism by SARS coronaviral infection: Potential implications for the SARS-CoV-2 modus operandi

Vavougios G.D. (2020)

COVID-19, the disease caused by the novel SARS-CoV-2, a betacoronavirus structurally similar to SARS-CoV. Based on both structural and syndromic similarities with SARS-CoV, a hypothesis is formed on SARS-CoV-2 potential ...

Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system

Farsalinos K., Niaura R., Le Houezec J., Barbouni A., Tsatsakis A., Kouretas D., Vantarakis A., Poulas K. (2020)

[No abstract available]

Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review

Tziastoudi M., Cholevas C., Stefanidis I., Theoharides T.C. (2022)

COVID-19 and ME/CFS present with some similar symptoms, especially physical and mental fatigue. In order to understand the basis of these similarities and the possibility of underlying common genetic components, we performed ...

Host – virus – drug interactions as determinants of COVID-19’s phenotypes: A data-driven hypothesis

Vavougios G.D. (2020)

There is a growing body of evidence on the significance of interactions between comorbidities, their treatments and COVID-19 clinical phenotypes. The hypothesis explored herein is that pharmaceutical compounds currently ...

Increased mortality among hypertensive COVID-19 patients: Pay a closer look on diuretics in mechanically ventilated patients

Tsolaki V., Zakynthinos G.E., Mantzarlis K., Makris D. (2020)

[No abstract available]

Nicotinic cholinergic system and covid-19: In silico identification of an interaction between sars-cov-2 and nicotinic receptors with potential therapeutic targeting implications

Farsalinos K., Eliopoulos E., Leonidas D.D., Papadopoulos G.E., Tzartos S., Poulas K. (2020)

While SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as the receptor for cell entry, it is important to examine other potential interactions between the virus and other cell receptors. Based on the clinical observation ...

Nicotinic cholinergic system and COVID-19: In silico identification of interactions between α7 nicotinic acetylcholine receptor and the cryptic epitopes of SARS-Co-V and SARS-CoV-2 Spike glycoproteins

Lagoumintzis G., Chasapis C.T., Alexandris N., Kouretas D., Tzartos S., Eliopoulos E., Farsalinos K., Poulas K. (2021)

SARS-CoV-2 is the coronavirus that originated in Wuhan in December 2019 and has spread globally. Studies have shown that smokers are less likely to be diagnosed with or be hospitalized for COVID-19 but, once hospitalized, ...

Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention

Nasi A., McArdle S., Gaudernack G., Westman G., Melief C., Rockberg J., Arens R., Kouretas D., Sjölin J., Mangsbo S. (2020)

During the current COVID-19 pandemic, a need for evaluation of already available drugs for treatment of the disease is crucial. Hereby, based on literature review from the current pandemic and previous outbreaks with corona ...

SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19

Tsatsakis A., Calina D., Falzone L., Petrakis D., Mitrut R., Siokas V., Pennisi M., Lanza G., Libra M., Doukas S.G., Doukas P.G., Kavali L., Bukhari A., Gadiparthi C., Vageli D.P., Kofteridis D.P., Spandidos D.A., Paoliello M.M.B., Aschner M., Docea A.O. (2020)

Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to severe acute respiratory distress. The severity of the illness can also extend from mild disease to life-threatening acute respiratory ...