Listar por tema "HIF-1"
Mostrando ítems 1-8 de 8
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2-Oxoglutarate-dependent oxygenases control hepcidin gene expression
(2008)Background/Aims: Hepcidin is a liver-produced hormone that regulates systemic iron homeostasis. Hepcidin expression is stimulated upon iron overload or inflammation while iron deficiency, anemia and tissue hypoxia are ... -
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
(2010)Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen conditions, embryogenesis ... -
CK1 delta restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1 alpha/ARNT complex formation
(2015)Proliferation of cells under hypoxia is facilitated by metabolic adaptation, mediated by the transcriptional activator Hypoxia Inducible Factor-1 (HIF-1). HIF-1 alpha, the inducible subunit of HIF-1 is regulated by oxygen ... -
Comparative effects of hypoxia on normal and immortalized human diploid fibroblasts
(2006)Hypoxia, a condition of reduced oxygen concentration, is observed in many physiological and pathophysiological states. However, there is rather limited information regarding hypoxic effects in the processes of immortalization ... -
Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1 alpha
(2005)Hypoxia-inducible factor 1 (HIF-1) activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions. HIF-1 is, in fact, a heterodimer of two ... -
Reconstitution of human hypoxia inducible factor HIF-1 in yeast: A simple in vivo system to identify and characterize HIF-1 alpha effectors
(2006)Hypoxia inducible factor I (HIF-1), the master regulator of hypoxia-activated genes, is involved in many diseases and is a valid drug target. In order to develop a simple and genetically tractable in vivo system for HIF-1 ... -
Transport of hypoxia-inducible factor HIF-1 alpha into the nucleus involves importins 4 and 7
(2009)Hypoxia-inducible transcription factor 1 (HIF-1) mediates the cellular response to hypoxia. HIF-1 activity is controlled via the synthesis, degradation or intracellular localization of its alpha subunit. HIF-1 alpha contains ...