Listar por autor "Sacher, M."
Mostrando ítems 1-2 de 2
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A freestanding proofreading domain is required for protein synthesis quality control in Archaea
Korencic, D.; Ahel, I.; Schelert, J.; Sacher, M.; Ruan, B.; Stathopoulos, C.; Blum, P.; Ibba, M.; Söll, D. (2004)Threonyl-tRNA synthetase (ThrRS) participates in protein synthesis quality control by selectively editing the misacylated species Ser-tRNAThr. In bacteria and eukaryotes the editing function of ThrRS resides in a highly ... -
A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition, among threonyl-tRNA synthetases
Ruan, B.; Bovee, M. L.; Sacher, M.; Stathopoulos, C.; Poralla, K.; Francklyn, C. S.; Söll, D. (2005)Borrelidin, a compound with anti-microbial and anti-angiogenic properties, is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS). The inhibition mechanism of borrelidin is not well understood. ...