Listar por autor "Lakka, A."
Mostrando ítems 1-3 de 3
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The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
Mylonis, I.; Lakka, A.; Tsakalof, A.; Simos, G. (2010)Hepatocellular carcinoma (HCC) is characterized by high mortality rates and resistance to conventional treatment. HCC tumors usually develop local hypoxia, which stimulates proliferation of cancer cells and renders them ... -
Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer
Lakka, A.; Mylonis, I.; Bonanou, S.; Simos, G.; Tsakalof, A. (2011)Hypoxia-Inducible Factor 1 (HIF-1), a transcriptional activator, is highly involved in the pathology of cancer. Inhibition of HIF-1 retards tumor growth and enhances treatment efficiency when used in combination with chemo- ... -
Molecular Imprinting of Tri-O-Acetyladenosine for the Synthetic Imitation of an ATP-Binding Cleft in Protein Kinases
Lakka, A.; Tsakalof, A. (2013)A number of diseases, including cancer, diabetes, and inflammation, are linked to deregulation of cell signaling pathways controlled by protein kinases. Inhibition of the kinases involved can interrupt aberrant signaling ...