Browsing by Subject "rat"
Now showing items 1-20 of 77
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The 5-HT2c receptor antagonist RO 60-0491 counteracts rats' retention deficits in a recognition memory task
(2005)The effects of the 5-HT2C receptor antagonist RO 60-0491 on recognition memory were investigated in the rat by using the object recognition task. Post-training administration of RO 60-0491 at 3 mg/kg, but not at 1 mg/kg, ... -
99mTc-sestamibi uptake in rat skeletal muscle and heart: Physiological determinants and correlations
(2009)The lipophilic cationic radiotracer 99mTc-sestamibi, known to be concentrated within mitochondria, is widely used for myocardial perfusion and to a lesser extent for muscle metabolism imaging. However, the exact distribution ... -
Activation of FADD-Dependent neuronal death pathways as a predictor of pathogenicity for LRRK2 mutations
(2016)Background Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. Objective We examined multiple ... -
Acute and repeated exposure with the nitric oxide (NO) donor sodium nitroprusside (SNP) differentially modulate responses in a rat model of anxiety
(2017)The nitric oxide (NO) donor sodium nitroprusside (SNP) actually is under investigation for the treatment of schizophrenia. That anxiety disorders are noted to occur commonly in schizophrenia patients is known. Contradictory ... -
Acute in vivo exposure to fentanyl reduces GABA immunoreactivity in the CA1 area of the rat hippocampus
(2008)The effect of in vivo fentanyl treatment on GABAergic immunoreactivity was studied in the CA1 area of the rat hippocampus. Animals were treated either with saline or fentanyl (4x80 μg/kg, s.c./15min). GABA immunohistochemistry ... -
Administration of exercise-conditioned plasma alters muscle catalase kinetics in rat: An argument for in vivo-like Km instead of in vitro-like Vmax
(2018)Maximal velocity (Vmax) is a well established biomarker for the assessment of tissue redox status. There is scarce evidence, though, that it does not probably reflect sufficiently in vivo tissue redox profile. Instead, the ... -
Adrenal glands of mice and rats: A comparative morphometric study
(2022)Mice and rats are among the most used laboratory animals. They share numerous similarities along with differences, some yet unexplored. One of them is the morphometry of their adrenal glands, whose characteristics may be ... -
Antidepressants influence somatostatin levels and receptor pharmacology in brain
(2009)This study investigated how the administration (acute and chronic) of the antidepressants citalopram and desmethylimipramine (DMI) influences somatostatin (somatotropin release inhibitory factor, SRIF) levels and SRIF ... -
Bovine colostrum supplementation improves bone metabolism in an osteoporosis-induced animal model
(2021)Osteoporosis is characterized by bone loss. The present study aims to investigate the effects of bovine colostrum (BC) on bone metabolism using ovariectomized (OVX) and orchidec-tomized (ORX) rat models. Twenty-seven-week-old ... -
Brattleboro rats have impaired apical membrane water permeability regulation in the outer medullary collecting duct principal cells
(2016)Vasopressin (AVP) regulates the body salt-water balance. Brattleboro rats carry an AVP gene mutation resulting in a recessive form of central diabetes insipidus, being ideal for AVP deficiency studies. Herein, we studied ... -
Cardiotoxicity of Chemical Substances: An Emerging Hazard Class
(2022)(1) Background: Human health risks and hazards from chemical substances are well regulated internationally. However, cardiotoxicity, is not defined as a stand-alone hazard and therefore there are no defined criteria for ... -
Chronic administration of plasma from exercised rats to sedentary rats does not induce redox and metabolic adaptations
(2020)The present study aimed to investigate whether endurance exercise-induced changes in blood plasma composition may lead to adaptations in erythrocytes, skeletal muscle and liver. Forty sedentary rats were randomly distributed ... -
Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities
(2013)Background: The Y-box protein-1 (YB-1) fulfills pleiotropic functions relating to gene transcription, mRNA processing, and translation. It remains elusive how YB-1 shuttling into the nuclear and cytoplasmic compartments ... -
Comparison of isotonic activation of cell volume regulation in rat peritoneal mesothelial cells and in kidney outer medullary collecting duct principal cells
(2021)In disease states, mesothelial cells are exposed to variable osmotic conditions, with high osmotic stress exerted by peritoneal dialysis (PD) fluids. They contain unphysiologically high concentrations of glucose and result ... -
Could X-ray microbeams inhibit angioplasty-induced restenosis in the rat carotid artery?
(2003)Background: Parallel, thin (<100 μm) planes of synchrotron-generated X rays, have been shown to spare normal tissues and preferentially damage tumors in animal models. The aim of the present study was to assess the effect ... -
Crocins, the active constituents of Crocus sativus L., counteracted apomorphine-induced performance deficits in the novel object recognition task, but not novel object location task, in rats
(2017)Schizophrenia is a chronic mental disease that affects nearly 1% of the population worldwide. Several lines of evidence suggest that the dopaminergic (DAergic) system might be compromised in schizophrenia. Specifically, ... -
Crocins, the bioactive components of crocus sativus l., counteract the disrupting effects of anesthetic ketamine on memory in rats
(2021)Consistent experimental evidence suggests that anesthetic doses of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine cause severe memory impairments in rodents. Crocins are among the various ... -
Dexamethasone has a biphasic effect on the c-Jun mRNA expression in the fetal and adult rat lung, in vivo
(1999)Glucocorticoids are a very potent therapy for the treatment of asthma as well for lung maturation in the prematurely newborn animals and human. It has been demonstrated that glucocorticoid receptors antagonize the actions ... -
Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation
(2022)Diabetic skin ulcer is one of the most common complications in patients suffering diabetes mellitus. Xanthohumol (XN), a hop-derived prenylated dietary flavonoid, has multiple health beneficial bioactivities. In the present ...