Browsing by Subject "host pathogen interaction"
Now showing items 1-11 of 11
-
COVID-19 and human reproduction: A pandemic that packs a serious punch
(2021)The COVID-19 pandemic has led to a worldwide health emergency that has impacted 188 countries at last count. The rapid community transmission and relatively high mortality rates with COVID-19 in modern times are relatively ... -
COVID-19 in Children with Asthma
(2021)Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects both children and adults but epidemiological and clinical data demonstrate that children are less likely to have a severe disease course or die. Furthermore, ... -
Epigenetic regulation of apoptosis via the PARK7 interactome in peripheral blood mononuclear cells donated by tuberculosis patients vs. healthy controls and the response to treatment: A systems biology approach
(2020)Aims: The aims of our study were to determine for the first time differentially expressed genes (DEGs) and enriched molecular pathways involving the PARK7 interactome in PBMCs donated from tuberculosis patients. Methods: ... -
Host – virus – drug interactions as determinants of COVID-19’s phenotypes: A data-driven hypothesis
(2020)There is a growing body of evidence on the significance of interactions between comorbidities, their treatments and COVID-19 clinical phenotypes. The hypothesis explored herein is that pharmaceutical compounds currently ... -
Impact of reactive oxygen species generation on Helicobacter pylori-related extragastric diseases: a hypothesis
(2017)Helicobacter pylori (H. pylori) induces reactive oxygen species (ROS) production that contribute to pathogenesis of a variety of H. pylori-related gastric diseases, as shown in animal and human studies. Helicobacter pylori ... -
Initial Immune Response in Escherichia coli, Staphylococcus aureus, and Candida albicans Bacteremia
(2020)Sepsis remains a leading cause of mortality worldwide and is characterized by sustained inflammatory responses, reflected as changes in the expression profile of cytokines with time. The aim of the present study was to ... -
Investigation and functional enrichment analysis of the human host interaction network with common gram-negative respiratory pathogens predicts possible association with lung adenocarcinoma
(2021)Haemophilus influenzae (Hi), Moraxella catarrhalis (MorCa) and Pseudomonas aeruginosa (Psa) are three of the most common gram-negative bacteria responsible for human respiratory diseases. In this study, we aimed to identify, ... -
Klebsiella pneumoniae: Virulence, Biofilm and Antimicrobial Resistance
(2017)[No abstract available] -
Mycobacterial immunomodulation and viral manipulation of neuronal copper efflux in the setting of sporadic Parkinson's disease: A multi – hit, outside – in hypothesis of its pathogenesis
(2020)Following Braak's hypothesis on the infectious pathogenesis of sporadic Parkinson's disease (sPD), several bacteria and viruses have been investigated as likely culprits. Recent research has focused on neuroinvasive influenza ... -
Overlapping host pathways between SARS-CoV-2 and its potential copathogens: An in silico analysis
(2020)Background: SARS-CoV-2 coinfection with other viral and bacterial pathogens and their interactions are increasingly recognized in the literature as potential determinants of COVID-19 phenotypes. The aim of this study was ... -
Peryton: A manual collection of experimentally supported microbe-disease associations
(2021)We present Peryton (https://dianalab.e-ce.uth.gr/peryton/), a database of experimentally supported microbe-disease associations. Its first version constitutes a novel resource hosting more than 7900 entries linking 43 ...