Browsing by Subject "guanosine triphosphate"

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Activation of FADD-Dependent neuronal death pathways as a predictor of pathogenicity for LRRK2 mutations

Melachroinou K., Leandrou E., Valkimadi P.-E., Memou A., Hadjigeorgiou G., Stefanis L., Rideout H.J. (2016)

Background Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. Objective We examined multiple ...