Browsing by Subject "drug therapy"

Acute and repeated exposure with the nitric oxide (NO) donor sodium nitroprusside (SNP) differentially modulate responses in a rat model of anxiety

Orfanidou M.A., Lafioniatis A., Trevlopoulou A., Touzlatzi N., Pitsikas N. (2017)

The nitric oxide (NO) donor sodium nitroprusside (SNP) actually is under investigation for the treatment of schizophrenia. That anxiety disorders are noted to occur commonly in schizophrenia patients is known. Contradictory ...

Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Outcomes in Patients Hospitalized for COVID-19

Pan M., Vasbinder A., Anderson E., Catalan T., Shadid H.R., Berlin H., Padalia K., O’hayer P., Meloche C., Azam T.U., Khaleel I., Michaud E., Blakely P., Bitar A., Huang Y., Zhao L., Pop-Busui R., Loosen S.H., Chalkias A., Tacke F., Giamarellos-Bourboulis E.J., Reiser J., Eugen-Olsen J., Hayek S.S. (2021)

BACKGROUND: Use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARB) is thought to affect COVID-19 through modulating levels of angiotensin-converting enzyme 2, the cell entry receptor ...

Anti-cd20 agents for multiple sclerosis: Spotlight on ocrelizumab and ofatumumab

Florou D., Katsara M., Feehan J., Dardiotis E., Apostolopoulos V. (2020)

Until recently, in the pathogenesis of Multiple Sclerosis (MS), the contribution of B cells has been largely underestimated, and the disease was considered a T-cell-mediated disorder. However, newer evidence shows that B ...

B-Cell Targeted Therapies in Patients with Multiple Sclerosis and Incidence of Headache: A Systematic Review and Meta-Analysis

Mavridis T., Papagiannakis N., Breza M., Vavougios G.D., Patas K., Daponte A., Laskaratos A., Archontakis-Barakakis P., Pantazopoulos I., Mitsikostas D.D. (2022)

Background: Multiple Sclerosis treatment with B-cell targeted therapies may be associated with an increased incidence of headache. We aimed to find and compare the association of B-cell targeted therapies with the incidence ...

Biomarkers in prostate-specific membrane antigen theranostics

Vlachostergios P.J., Zachos I., Tzortzis V. (2021)

Theranostics of prostate cancer (PC) represents a growing area of development of imaging agents and targeted radionuclide therapeutics against a major target, prostate specific membrane antigen (PSMA). In view of the ...

Drug genetic associations with COVID-19 manifestations: a data mining and network biology approach

Charitou T., Kontou P.I., Tamposis I.A., Pavlopoulos G.A., Braliou G.G., Bagos P.G. (2022)

Available drugs have been used as an urgent attempt through clinical trials to minimize severe cases of hospitalizations with Coronavirus disease (COVID-19), however, there are limited data on common pharmacogenomics ...

Early corticosteroid initiation delays viral RNA clearance in respiratory secretions of COVID-19 patients

Pantazopoulos I., Mavrovounis G., Kyritsis A., Perlepe G., Miziou A., Gourgoulianis K. (2021)

[No abstract available]

Effects of Anesthetic Ketamine on Anxiety-Like Behaviour in Rats

Pitsikas N., Georgiadou G., Delis F., Antoniou K. (2019)

There is scarce information regarding the effects of anesthetic doses of the non-competitive N-methyl-d-aspartate receptor antagonist ketamine on anxiety. The current study evaluated the acute effects of intraperitoneally ...

Effects of varenicline therapy in combination with advanced behavioral support on smoking cessation and quality of life in inpatients with acute exacerbation of COPD, bronchial asthma, or community-acquired pneumonia: A prospective, open-label, preference-based, 52-week, follow-up trial

Politis A., Ioannidis V., Gourgoulianis K.I., Daniil Z., Hatzoglou C. (2018)

Quitting smoking is the most important element in the therapeutic management of chronic respiratory diseases. Combining pharmacotherapy with behavioral support increases smoking cessation success rates. In addition, ...

The gabaa-benzodiazepine receptor antagonist flumazenil abolishes the anxiolytic effects of the active constituents of crocus sativus l. Crocins in rats

Pitsikas N., Tarantilis P.A. (2020)

Anxiety is a chronic severe psychiatric disorder. Crocins are among the various bioactive components of the plant Crocus sativus L. (Iridaceae) and their implication in anxiety is well-documented. However, which is the ...

History of induced abortions and frailty in older Greek women: results from the HELIAD study

Mourtzi N., Yannakoulia M., Ntanasi E., Kosmidis M.H., Anastasiou C.A., Dardiotis E., Hadjigeorgiou G., Megalou M., Sakka P., Scarmeas N. (2018)

Purpose: Women are almost twice as likely as men to develop frailty and early-traumatic experiences related to reproduction may have a role to play. The purpose of this study was to investigate the association between a ...

Intensity of Humoral Immune Responses, Adverse Reactions, and Post-Vaccination Morbidity after Adenovirus Vector-Based and mRNA Anti-COVID-19 Vaccines

Voulgaridi I., Sarrou S., Dadouli A., Peristeri A.-M., Nasika A., Onoufriadis I., Kyritsi M.A., Anagnostopoulos L., Theodoridou A., Avakian I., Pappa D., Konstantinou A.-K., Papadamou G., Mouchtouri V.A., Petinaki E., Speletas M., Hadjichristodoulou C. (2022)

The aim of the study was to compare mRNA vaccine BNT162b2 with adenovirus vector- based vaccines in terms of presence of adverse reactions, immunogenicity, and protection against COVID-19. A total of 270 individuals were ...

Interleukin-6 inhibitors reduce mortality in coronavirus disease-2019: An individual patient data meta-analysis from randomized controlled trials

Tasoudis P.T., Arvaniti C.K., Adamou A.T., Belios I., Stone J.H., Horick N., Sagris D., Dalekos G.N., Ntaios G. (2022)

Objective: To assess the efficacy of IL-6 inhibitors compared to standard of care (SOC) in COVID-19 patients. Data Sources: A systematic review of the MEDLINE and Scopus databases (last search: October 8th, 2021) was ...

Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo

Le Reste P.J., Pineau R., Voutetakis K., Samal J., Jégou G., Lhomond S., Gorman A.M., Samali A., Patterson J.B., Zeng Q., Pandit A., Aubry M., Soriano N., Etcheverry A., Chatziioannou A., Mosser J., Avril T., Chevet E. (2020)

Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for ...

Microbleeds and the Effect of Anticoagulation in Patients with Embolic Stroke of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Randomized Clinical Trial

Shoamanesh A., Hart R.G., Connolly S.J., Kasner S.E., Smith E.E., Martí-Fàbregas J., Liu Y.Y., Uchiyama S., Mikulik R., Veltkamp R., O'Donnell M.J., Ntaios G., Muir K.W., Field T.S., Santo G.C., Olavarria V., Mundl H., Lutsep H., Berkowitz S.D., Sharma M. (2021)

Importance: The reported associations of cerebral microbleeds with recurrent stroke and intracerebral hemorrhage have raised concerns regarding antithrombotic treatment in patients with a history of stroke and microbleeds ...

Nasopharyngeal Wash with Normal Saline Decreases SARS-CoV-2 Viral Load: A Randomized Pilot Controlled Trial

Pantazopoulos I., Chalkias A., Mavrovounis G., Dimeas I., Sinis S., Miziou A., Rouka E., Poulas K., Gourgoulianis K. (2022)

Background. Although great progress has been made over the past 2 years in the scientific understanding of the biology, epidemiology, and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), case ...

The nitric oxide donor molsidomine induces anxiolytic-like behaviour in two different rat models of anxiety

Kalouda T., Pitsikas N. (2015)

Experimental evidence indicates the implication of the nitric oxide (NO) in anxiety. Contradictory results were reported however, concerning the effects of NO donors in animal models of anxiety disorders. The present study ...

The Remarkable Evolutionary Plasticity of Coronaviruses by Mutation and Recombination: Insights for the COVID-19 Pandemic and the Future Evolutionary Paths of SARS-CoV-2

Amoutzias G.D., Nikolaidis M., Tryfonopoulou E., Chlichlia K., Markoulatos P., Oliver S.G. (2022)

Coronaviruses (CoVs) constitute a large and diverse subfamily of positive-sense sin-gle-stranded RNA viruses. They are found in many mammals and birds and have great importance for the health of humans and farm animals. ...

Remdesivir-induced Bradycardia is not Associated with Worse Outcome in Patients with COVID-19: A Retrospective Analysis

Pantazopoulos I., Mavrovounis G., Dimeas G., Zikos N., Pitsikou M., Rousogianni E., Mermiri M., Michou A., Spanos M., Maniotis C., Chalkias A., Laou E., Zakynthinos G., Chatzis D., Gourgoulianis K. (2022)

Background: COVID-19, is primarily a respiratory illness but is known to cause extrapulmonary manifestations, especially on the cardiovascular system. Bradycardia is commonly reported in COVID-19 patients despite no prior ...

Repeated but not acute exposure with a low dose range of the nitric oxide (NO) donor sodium nitroprusside (SNP) induces anxiolytic-like behaviour in a dose-independent manner in two different rat models of anxiety

Papageorgoulis A., Fallon P., Mpalantes N., Papageorgouli D., Pitsikas N. (2020)

Sodium nitroprusside (SNP) is a nitric oxide (NO) donor which actually is under assessment as a potential candidate for the treatment of schizophrenia. It is well documented that anxiety symptoms are a prominent future in ...