Browsing by Subject "drug metabolite"
Now showing items 1-3 of 3
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Caffeine metabolism in liver cirrhosis
(2005)Caffeine is metabolized primarily by CYP1A2. Several methods have been developed for the in vivo assessment of CYP1A2 activity using caffeine as a probe drug (2). These methods include the determination of caffeine clearance ... -
Endogenous Melatonin Levels and Therapeutic Use of Exogenous Melatonin in Migraine: Systematic Review and Meta-Analysis
(2020)Background: Sleep disorders and circadian dysregulation appear to be associated with primary headache disorders. Objective: The aim of this study was to review the existing evidence for the deployment of melatonin in ... -
On-line SPE sample treatment as a tool for method automatization and detection limits reduction: Quantification of 25-hydroxyvitamin D3/D2
(2017)The development and approbation of new, automated UHPLC-DAD method for the quantification of 25-hydroxyvitamin D3/D2 (25OH-D3/D2) metabolites in plasma/serum for the evaluation of patient's vitamin D status are presented. ...