Browsing by Subject "chondrocyte"

Article dual role of sirt1 in autophagy and lipid metabolism regulation in osteoarthritic chondrocytes

Papageorgiou A.-A., Goutas A., Trachana V., Tsezou A. (2021)

Background and Objectives: Osteoarthritis (OA) is one of the most common and highly prevalent types of arthritis, also considered a multiphenotypic disease with a strong metabolic com-ponent. Ageing is the primary risk ...

The autophagic response to oxidative stress in osteoarthritic chondrocytes is deregulated

Goutas A., Syrrou C., Papathanasiou I., Tsezou A., Trachana V. (2018)

It has been reported that oxidative stress (OS) is involved in the pathogenesis of osteoarthritis (OA) and that defective autophagy is accompanying this age-related disease. Moreover, it has been proposed that induction ...

Cholesterol metabolism related genes in osteoarthritis

Papathanasiou I., Anastasopoulou L., Tsezou A. (2021)

Cholesterol homeostasis plays a significant role in skeletal development and the dysregulation of cholesterol-related mechanism has been shown to be involved in the development of cartilage diseases including osteoarthritis ...

Chondrocyte protein co-synthesis network analysis links ECM mechanosensing to metabolic adaptation in osteoarthritis

Destouni A., Tsolis K.C., Economou A., Papathanasiou I., Balis C., Mourmoura E., Tsezou A. (2021)

Background: Knee osteoarthritis (OA) is one of the most common structural OA disorders globally. Incomplete understanding of the fundamental biological aspects of osteoarthritis underlies the current lack of effective ...

DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis

Papathanasiou I., Trachana V., Mourmoura E., Tsezou A. (2019)

Aims: Previous studies have demonstrated that transcriptional silencing of miRNAs due to DNA hypermethylation is associated with different pathologies. It has also been reported that abnormal expression of miR-140-5p and ...

Flash proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response

Velalopoulou A., Karagounis I.V., Cramer G.M., Kim M.M., Skoufos G., Goia D., Hagan S., Verginadis I.I., Shoniyozov K., Chiango J., Cerullo M., Varner K., Yao L., Qin L., Hatzigeorgiou A.G., Minn A.J., Putt M., Lanza M., Assenmacher C.-A., Radaelli E., Huck J., Diffenderfer E., Dong L., Metz J., Koumenis C., Cengel K.A., Maity A., Busch T.M. (2021)

In studies of electron and proton radiotherapy, ultrahigh dose rates of FLASH radiotherapy appear to produce fewer toxicities than standard dose rates while maintaining local tumor control. FLASHproton radiotherapy (F-PRT) ...

Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes

Papathanasiou I., Mourmoura E., Balis C., Tsezou A. (2020)

Purpose: MiR-146a acts as a negative inflammatory mediator in different diseases and has been implicated in osteoarthritis (OA) pathogenesis. In our study, we investigated the association between miR-SNP rs2910164 and OA ...

Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROS

Mourmoura E., Papathanasiou I., Trachana V., Konteles V., Tsoumpou A., Goutas A., Papageorgiou A.-A., Stefanou N., Tsezou A. (2022)

Leptin and ROS are implicated in the regulation of inflammatory pathways including NLRP3-inflammasome. We investigated the functional link between leptin, ROS and NLRP3-inflammasome formation/activation in osteoarthritis ...

Molecular changes indicative of cartilage degeneration and osteoarthritis development in patients with anterior cruciate ligament injury Pathophysiology of musculoskeletal disorders

Papathanasiou I., Michalitsis S., Hantes M.E., Vlychou M., Anastasopoulou L., Malizos K.N., Tsezou A. (2016)

Background: Anterior cruciate ligament (ACL) tear is considered a risk factor for osteoarthritis development. The purpose of our study was to investigate the expression levels of the apoptotic enzyme caspase 3, pro-inflammatory ...

Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes

Ntoumou E., Tzetis M., Braoudaki M., Lambrou G., Poulou M., Malizos K., Stefanou N., Anastasopoulou L., Tsezou A. (2017)

Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics ...