Browsing by Subject "STAT protein"

Endocrine resistance and epigenetic reprogramming in estrogen receptor positive breast cancer

Dimitrakopoulos F.-I., Kottorou A., Tzezou A. (2021)

Despite the enormous advances during the last three decades, breast cancer continues to be the most frequent type of cancer as well as one of the most frequent cancer-related causes of death in women. Therapeutic management ...

IFNs-signaling effects on lung cancer: an up-to-date pathways-specific review

Galani V., Kastamoulas M., Varouktsi A., Lampri E., Mitselou A., Arvanitis D.L. (2017)

IFNs have found important applications in clinical medicine, including the treatment of lung malignancies. The biological effect of the IFN-receptor signaling is regulated essentially by three factors: the expression profile ...

Multiple outcome meta-analysis of gene-expression data in inflammatory bowel disease

Vennou K.E., Piovani D., Kontou P.I., Bonovas S., Bagos P.G. (2020)

We performed a multivariate meta-analysis of microarray data in Crohn's disease (CD) and Ulcerative colitis (UC), which are the main forms of inflammatory bowel disease (IBD). They share similar symptoms but differ in the ...

Myeloid-derived suppressor cells: Major figures that shape the immunosuppressive and angiogenic network in cancer

Vetsika E.-K., Koukos A., Kotsakis A. (2019)

Myeloid-derived suppressor cells (MDSCs) constitute a vast population of immature myeloid cells implicated in various conditions. Most notably, their role in cancer is of great complexity. They exert immunosuppressive ...

Reporting on the Role of miRNAs and Affected Pathways on the Molecular Backbone of Ovarian Insufficiency: A Systematic Review and Critical Analysis Mapping of Future Research

Rapani A., Nikiforaki D., Karagkouni D., Sfakianoudis K., Tsioulou P., Grigoriadis S., Maziotis E., Pantou A., Voutsina A., Pantou A., Koutsilieris M., Hatzigeorgiou A., Pantos K., Simopoulou M. (2021)

Ovarian insufficiency is identified as a perplexing entity in the long list of pathologies impairing fertility dynamics. The three distinct classifications of ovarian insufficiency are poor ovarian response, premature ...

Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis

Braliou G.G., Kontou P.I., Boleti H., Bagos P.G. (2019)

Leishmaniases are cutaneous, mucocutaneous, and visceral diseases affecting humans and domesticated animals mostly in the tropical and subtropical areas of the planet. Host genetics have been widely investigated for their ...