Browsing by Subject "MOLECULAR ASSOCIATION"
Now showing items 1-6 of 6
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Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index
(2011)Background: The biological justification for the choice of the genetic mode in genetic association studies (GAS) is seldom available. Then, the mode of inheritance is approximated by investigating a number of non-orthogonal ... -
Genetic model selection in genome-wide association studies: robust methods and the use of meta-analysis
(2013)In genetic association studies (GAS) as well as in genome-wide association studies (GWAS), the mode of inheritance (dominant, additive and recessive) is usually not known a priori. Assuming an incorrect mode of inheritance ... -
Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature
(2011)Background: Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes ... -
A method for meta-analysis of case-control genetic association studies using logistic regression
(2007)We propose here a simple and robust approach for meta-analysis of molecular association studies. Making use of the binary structure of the data, and by treating the genotypes as independent variables in a logistic regression, ... -
A Multipoint Method for Meta-Analysis of Genetic Association Studies
(2010)Meta-analyses of genetic association studies are usually performed using a single polymorphism at a time, even though in many cases the individual studies report results from partially overlapping sets of polymorphisms. ... -
Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches
(2008)Objective: The aim of the study was to consider statistical and methodological issues affecting the results of meta-analysis of genetic association studies for pertinent gene-disease associations. Although the basic ...