Browsing by Author "Dimas, K."
Now showing items 1-18 of 18
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Activation of mTOR signaling in medullary and aggressive papillary thyroid carcinomas
Kouvaraki, M. A.; Liakou, C.; Paraschi, A.; Dimas, K.; Patsouris, E.; Tseleni-Balafouta, S.; Rassidakis, G. Z.; Moraitis, D. (2011)Background. Because mammalian target of rapamycin (mTOR) may be involved in thyroid carcinogenesis, we investigated the expression and activation patterns of mTOR signaling proteins in thyroid carcinoma cells and tumors ... -
Additive enhancement of apoptosis by TRAIL and fenretinide in metastatic breast cancer cells in vitro
Ulukaya, E.; Sarimahmut, M.; Cevatemre, B.; Ari, F.; Yerlikaya, A.; Dimas, K. (2014)Successful management of metastatic breast cancer still needs better chemotherapeutic approaches. The combination of fenretinide (4-HPR), a synthetic retinoid inducing apoptosis by ROS generation, and TRAIL, a cell death ... -
Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo
Ulukaya, E.; Ari, F.; Dimas, K.; Ikitimur, E. I.; Guney, E.; Yilmaz, V. T. (2011)Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 ... -
Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro
Ulukaya, E.; Ari, F.; Dimas, K.; Sarimahmut, M.; Guney, E.; Sakellaridis, N.; Yilmaz, V. T. (2011)Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd(sac)(terpy)](sac).4H(2)O (Complex ... -
Curcumin analogues as possible anti-proliferative & anti-inflammatory agents
Katsori, A. M.; Chatzopoulou, M.; Dimas, K.; Kontogiorgis, C.; Patsilinakos, A.; Trangas, T.; Hadjipavlou-Litina, D. (2011)A series of novel curcumin analogues has been designed, synthesized and tested in vitro/in vivo as potential multi-target agents. Their anti-proliferative and anti-inflammatory activities were studied. Compounds 1b and 2b ... -
Effect of ET-1, FGF-2, and HGF on intracellular steroidogenesis in prostate cancer cells
Vasileiou, C.; Hatzidaki, E.; Karkabounas, A.; Maragkouli, E.; Vaiou, M.; Dimas, K.; Liakos, P.; Lekka, M.; Papandreou, C. (2013) -
Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo
Tsirmoula, S.; Dimas, K.; Hatziapostolou, M.; Lamprou, M.; Ravazoula, P.; Papadimitriou, E. (2012)Pleiotrophin (PTN) is a heparin-binding growth factor with diverse functions related to tumor growth, angiogenesis, and metastasis. Pleiotrophin seems to have a significant role in prostate cancer cell growth and to mediate ... -
In vitro activity of dietary flavonol congeners against human cancer cell lines
Tsimplouli, C.; Demetzos, C.; Hadzopoulou-Cladaras, M.; Pantazis, P.; Dimas, K. (2012)Flavonoids have physiological activity and a variety of pharmacological properties, including anticancer activity in vitro, but structure-anticancer activity relationships are unclear. The objectives of this work were to ... -
The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action
Mahaira, L. G.; Tsimplouli, C.; Sakellaridis, N.; Alevizopoulos, K.; Demetzos, C.; Han, Z.; Pantazis, P.; Dimas, K. (2011)The labdane diterpene sclareol has demonstrated significant cytotoxicity against human tumor cell lines and human colon cancer xenografts. Therefore, there is need to elucidate the mode of action of this compound as very ... -
Marilines A-C: Novel phthalimidines from the sponge-derived fungus Stachylidium sp
Almeida, C.; Hemberger, Y.; Schmitt, S. M.; Bouhired, S.; Natesan, L.; Kehraus, S.; Dimas, K.; Gütschow, M.; Bringmann, G.; König, G. M. (2012)A marine-derived fungus of the genus Stachylidium was isolated from the sponge Callyspongia cf. C. flammea. Chemical investigation of the bioactive fungal extract led to the isolation of the novel phthalimidine derivatives ... -
Polymersomes from Polypeptide Containing Triblock Co- and Terpolymers for Drug Delivery against Pancreatic Cancer: Asymmetry of the External Hydrophilic Blocks
Iatrou, H.; Dimas, K.; Gkikas, M.; Tsimblouli, C.; Sofianopoulou, S. (2014)Well-defined amphiphilic polymers of the ABA and ABC type are synthesized, where A is poly(L-lysine hydrochloride) (PLL), B is poly(g-benzyl-(d7) L-glutamate) (PBLG(-d7)), and C is poly(ethylene oxide) (PEO). The two ... -
Preparation of sirna-encapsulated plga nanoparticles for sustained release of sirna and evaluation of encapsulation efficiency
Pantazis, P.; Dimas, K.; Wyche, J. H.; Anant, S.; Houchen, C. W.; Panyam, J.; Ramanujam, R. P. (2012)Nanoparticles (NPs) formulated using poly (d,l-lactide-co-glycolide) (PLGA), a biodegradable, biocompatible, and clinically approved polymer, have been widely used for targeted drug delivery. Here we provide methods for ... -
Promising Anti-cancer Activity of a Novel Palladium (II) Complex on Human Breast Cancer Cells in Vitro and in Vivo
Ulukaya, E.; Ari, F.; Dimas, K.; Ikitimur, E. I.; Guney, E.; Sakellaridis, N.; Yilmaz, V. T. (2011) -
Shikonin-loaded liposomes as a new drug delivery system: Physicochemical characterization and in vitro cytotoxicity
Kontogiannopoulos, K. N.; Assimopoulou, A. N.; Dimas, K.; Papageorgiou, V. P. (2011)Alkannin and shikonin are naturally occurring hydroxynaphthoquinones with a well-established spectrum of wound healing, antimicrobial, anti-inflammatory, and antioxidant activities. Recently, extensive scientific effort ... -
SIN1, a critical component of the mTOR-Rictor complex, is overexpressed and associated with AKT activation in medullary and aggressive papillary thyroid carcinomas
Moraitis, D.; Karanikou, M.; Liakou, C.; Dimas, K.; Tzimas, G.; Tseleni-Balafouta, S.; Patsouris, E.; Rassidakis, G. Z.; Kouvaraki, M. A. (2014)Background. Mammalian target of rapamycin (mTOR) forms 2 active complexes in the cell: the rapamycin-sensitive mTOR-Raptor (mTORC1) and the rapamycin-insensitive mTOR-Rictor (mTORC2). The latter activates AKT kinase, which ... -
Steroidal Cardiac Na+/K (+) ATPase Inhibitors Exhibit Strong Anti-Cancer Potential in vitro and in Prostate and Lung Cancer Xenografts in vivo
Dimas, K.; Papadopoulou, N.; Baskakis, C.; Prousis, K. C.; Tsakos, M.; Alkahtani, S.; Honisch, S.; Lang, F.; Calogeropoulou, T.; Alevizopoulos, K.; Stournaras, C. (2014)Sodium potassium pump (Na+/K+ ATPase) is a validated pharmacological target for the treatment of congestive heart failure. Recent data with inotropic drugs such as digoxin & digitoxin (digitalis) suggest a potent anti-cancer ... -
A Steroidal Na+/K+ ATPase Inhibitor Triggers Pro-apoptotic Signaling and Induces Apoptosis in Prostate and Lung Tumor Cells
Honisch, S.; Alkahtani, S.; Kounenidakis, M.; Liu, G. L.; Alarifi, S.; Al-Yahya, H.; Dimas, K.; AlKahtane, A. A.; Prousis, K. C.; Al-Dahmash, B.; Calogeropoulou, T.; Alevizopoulos, K.; Lang, F.; Stournaras, C. (2014)Recently we have reported potent anti-cancer actions of various steroidal Na+/K+ ATPase inhibitors in multiple cell lines. Furthermore, the most powerful compound identified in this study, the 3-[(R)-3-pyrrolidinyl]oxime ... -
Synthesis and biological evaluation of modified purine homo-N-nucleosides containing pyrazole or 2-pyrazoline moiety
Thalassitis, A.; Katsori, A. M.; Dimas, K.; Hadjipavlou-Litina, D. J.; Pyleris, F.; Sakellaridis, N.; Litinas, K. E. (2014)9-Substituted (pyrazol-5-yl)methyl- or (2-pyrazolin-5-yl)methyl-9H-purines were synthesized from 9-allyl-6-chloro-9H-purine through the 1,3-dipolar cycloaddition reaction with nitrile imines, prepared in situ from the ...