Browsing by Author "Bonovas, S."
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The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: a Mendelian randomization meta-analysis
Nikolopoulos, G. K.; Bagos, P. G.; Tsangaris, I.; Tsiara, C. G.; Kopterides, P.; Vaiopoulos, A.; Kapsimali, V.; Bonovas, S.; Tsantes, A. E. (2014)Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ... -
Bisphosphonate use and risk of colorectal cancer: a systematic review and meta-analysis
Bonovas, S.; Nikolopoulos, G.; Bagos, P. (2013)AimA growing body of evidence suggests that bisphosphonates may have chemopreventive potential against colorectal cancer. Our aim was to examine this association through a meta-analysis of observational studies. MethodsA ... -
Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials
Bonovas, S.; Nikolopoulos, G.; Filioussi, K.; Peponi, E.; Bagos, P.; Sitaras, N. M. (2010)A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this ... -
Developing the Evidence Base for Cancer Chemoprevention: Use of Meta-Analysis
Nikolopoulos, G. K.; Bagos, P. G.; Bonovas, S. (2011)Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ... -
An Ecological Study of the Determinants of Differences in 2009 Pandemic Influenza Mortality Rates between Countries in Europe
Nikolopoulos, G.; Bagos, P.; Lytras, T.; Bonovas, S. (2011)Background: Pandemic A (H1N1) 2009 mortality rates varied widely from one country to another. Our aim was to identify potential socioeconomic determinants of pandemic mortality and explain between-country variation. ... -
Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome
Tsantes, A. E.; Kopterides, P.; Bonovas, S.; Bagos, P.; Antonakos, G.; Nikolopoulos, G. K.; Gialeraki, A.; Kapsimali, V.; Kyriakou, E.; Kokori, S.; Dima, K.; Armaganidis, A.; Tsangaris, I. (2013)Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains ... -
Use of Fibrates and Cancer Risk: A Systematic Review and Meta-Analysis of 17 Long-Term Randomized Placebo-Controlled Trials
Bonovas, S.; Nikolopoulos, G. K.; Bagos, P. G. (2012)Background: Fibrates comprise a class of well-established antilipidemic agents that significantly reduce cardiovascular events. Given the concerns of cancer with fibrate therapy, we undertook a systematic review and ... -
VENOUS OXYGEN SATURATION AND LACTATE GRADIENT FROM SUPERIOR VENA CAVA TO PULMONARY ARTERY IN PATIENTS WITH SEPTIC SHOCK
Kopterides, P.; Bonovas, S.; Mavrou, I.; Kostadima, E.; Zakynthinos, E.; Armaganidis, A. (2009)Monitoring of central venous oxygen saturation (S(cv)O(2)) is considered comparable with mixed venous oxygen saturation (S(v)O(2)) in the initial resuscitation phase of septic shock. Our aim was to assess their agreement ...