Πλοήγηση ανά Θέμα "FACTOR 1-ALPHA"
Αποτελέσματα 1-8 από 8
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Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
(2012)Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor activity in the clinical setting, particularly for treatment of hematological malignancies. At the preclinical level, its action is shown ... -
Cobalt induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
(2006)The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1 alpha (HIF-1 alpha) in normoxia. DFO stabilizes HIF-1 alpha from proteolysis by inhibiting the activity of iron-dependent ... -
Cobalt induces hypoxia-inducible factor-1 alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism
(2004)Cobalt can mimic hypoxia and has been implicated as a cause of lung defects. However, the effect of cobalt on airway smooth muscle (ASM) cells has not been analyzed in detail. In this article, we use primary cultures of ... -
Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1 alpha
(2005)Hypoxia-inducible factor 1 (HIF-1) activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions. HIF-1 is, in fact, a heterodimer of two ... -
The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron
(2007)Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ... -
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
(2001)Hypoxia inducible factor 1a and 2a (HIF-1a and HIF-2a) are key proteins regulating cellular response to hypoxia, Because the efficacy of photodynamic therapy (PDT) is dependent on the presence of oxygen, the assessment of ... -
Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma
(2009)Neoangiogenesis has been documented in small cell lung carcinoma (SCLC). In addition, antiangiogenic therapies are being tested in clinical trials that involve SCLC. However, study of the underlying mechanisms has been ... -
Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study
(2008)Background: The hypoxia-inducible factor (HIF) has emerged as an attractive target for cancer therapy. The few publications addressing the prognostic significance of Hypoxia-Inducible Factor 1 alpha (HIF-1 alpha) cellular ...