Auflistung Nach Schlagwort "tumor suppressor gene"

Aberrant methylation of c-myc and c-fos protooncogenes and p53 tumor suppressor gene in myelodysplastic syndromes and acute non-lymphocytic leukemia

Papaggeli, P. C.; Kortsaris, A. C.; Matsouka, P. T. (2003)

Purpose: Aberrant methylation, as an epigenetic phenomenon, may precede and regulate the expression of genes involved in transformation mechanisms that lead to leukemogenesis of hemopoietic cells. The genes involved mostly ...

Association of p16 (CDKN2A) polymorphisms with the development of HPV16-related precancerous lesions and cervical cancer in the Greek population

Tsakogiannis D., Moschonas G.D., Bella E., Kyriakopoulou Z., Amoutzias G.D., Dimitriou T.G., Kottaridi C., Markoulatos P. (2018)

The tumor suppressor protein p16 plays a fundamental role in cell cycle regulation and exerts a protective effect against tumor growth. Two different polymorphisms at positions 540 and 580 at the 3′UTR of exon 3 of p16 ...

BRCA1 and BRCA2 germline testing in Cretan isolates reveals novel and strong founder effects

Apostolou P., Fostira F., Kouroussis C., Kalfakakou D., Delimitsou A., Agelaki S., Androulakis N., Christodoulou C., Kalbakis K., Kalykaki A., Sanidas E., Papadimitriou C., Vamvakas L., Georgoulias V., Mavroudis D., Yannoukakos D., Konstantopoulou I., Saloustros E. (2020)

Germline BRCA1 and BRCA2 loss-of-function variants have been linked to increased breast and ovarian cancer risk, with more than 5,000 distinct pathogenic variants being reported worldwide. Among individuals of Greek descent, ...

Bridging plant and human radiation response and DNA repair through an in silico approach

Nikitaki Z., Pavlopoulou A., Holá M., Donà M., Michalopoulos I., Balestrazzi A., Angelis K.J., Georgakilas A.G. (2017)

The mechanisms of response to radiation exposure are conserved in plants and animals. The DNA damage response (DDR) pathways are the predominant molecular pathways activated upon exposure to radiation, both in plants and ...

Cell migration leads to spatially distinct but clonally related airway cancer precursors

Pipinikas, C. P.; Kiropoulos, T. S.; Teixeira, V. H.; Brown, J. M.; Varanou, A.; Falzon, M.; Capitanio, A.; Bottoms, S. E.; Carrol, B.; Navani, N.; McCaughan, F.; George, J. P.; Giangreco, A.; Wright, N. A.; McDonald, S. A. C.; Graham, T. A.; Janes, S. M. (2014)

Background Squamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have a natural history of development progressing through increasing ...

DNA damage and differential gene expression associated with physical stress in gilthead seabream (Sparus aurata)

Malandrakis E.E., Dadali O., Golomazou E., Kavouras M., Dailianis S., Chadio S., Exadactylos A., Panagiotaki P. (2016)

Fish stress may result in inhibition of reproduction, development and growth. Thus, appropriate indices should be developed to accurately define the physiological plasticity of fish, in terms of coping with stress. Sea ...

Enhancer of rudimentary homologue interacts with scaffold attachment factor B at the nuclear matrix to regulate SR protein phosphorylation

Drakouli S., Lyberopoulou A., Papathanassiou M., Mylonis I., Georgatsou E. (2017)

Scaffold attachment factor B1 (SAFB1) is an integral component of the nuclear matrix of vertebrate cells. It binds to DNA on scaffold/matrix attachment region elements, as well as to RNA and a multitude of different proteins, ...

The fate of BRCA1-related germline mutations in triple-negative breast tumors

Kotoula V., Fostira F., Papadopoulou K., Apostolou P., Tsolaki E., Lazaridis G., Manoussou K., Zagouri F., Pectasides D., Vlachos I., Tikas I., Lakis S., Konstantopoulou I., Pentheroudakis G., Gogas H., Papakostas P., Christodoulou C., Bafaloukos D., Razis E., Karavasilis V., Bamias C., Yannoukakos D., Fountzilas G. (2017)

The preservation of pathogenic BRCA1/2 germline mutations in tumor tissues is usually not questioned, while it remains unknown whether these interact with somatic genotypes for patient outcome. Herein we compared germline ...

Immunohistochemicall expression of the p53, p21/Waf-1, Rb, p16 and Ki67 proteins in multiple myeloma

Kanavaros, P.; Stefanaki, K.; Vlachonikolis, J.; Papalazarou, D.; Rontogianni, D.; Arvanitis, D.; Antonakopoulos, G.; Gorgoulis, V.; Bai, M.; Agnantis, N. J. (2000)

The aim of this study was to investigate the immunohistochemical expression of the proteins p53, Waf-l/p21, Rb, p16 and Ki67 in 38 cases of multiple myelomas (MM) and 4 cases of solitary extramedullary plasmacytomas in ...

The mast cell – Neurofibromatosis connection

Antonopoulos D., Tsilioni I., Balatsos N.A.A., Gourgoulianis K.I., Theoharides T.C. (2019)

[No abstract available]

Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach

Pavlopoulou A., Bagos P.G., Koutsandrea V., Georgakilas A.G. (2017)

Although radiation therapy is a treatment of choice for cancer, a high percentage of patients develop adverse effects in normal tissue following radiotherapy, mainly, due to genetic factors. Notably, although it is established ...

Prognostic significance of tumor genotypes and CD8+ infiltrates in stage I-III colorectal cancer

Fountzilas E., Kotoula V., Tikas I., Manousou K., Papadopoulou K., Poulios C., Karavasilis V., Efstratiou I., Pectasides D., Papaparaskeva K., Varthalitis I., Christodoulou C., Papatsibas G., Chrisafi S., Glantzounis G.K., Psyrri A., Aravantinos G., Koliou G.-A., Koukoulis G.K., Pentheroudakis G.E., Fountzilas G. (2018)

Background: We explored the clinical significance of tumor genotypes and immunophenotypes in non-metastatic colorectal cancer (CRC). Methods: In primary tumors (paraffin blocks) from 412 CRC patients treated with adjuvant ...