Auflistung Nach Schlagwort "structure analysis"

Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease

Sarri C.A., Papadopoulos G.E., Papa A., Tsakris A., Pervanidou D., Baka A., Politis C., Billinis C., Hadjichristodoulou C., Mamuris Z. (2018)

The MHC class II region in humans is highly polymorphic. Each MHC molecule is formed by an α and a β chain, produced by different genes, creating an antigen-binding groove. In the groove there are several pockets into which ...

The ammonium sulfate inhibition of human angiogenin

Chatzileontiadou D.S.M., Tsirkone V.G., Dossi K., Kassouni A.G., Liggri P.G.V., Kantsadi A.L., Stravodimos G.A., Balatsos N.A.A., Skamnaki V.T., Leonidas D.D. (2016)

In this study, we investigate the inhibition of human angiogenin by ammonium sulfate. The inhibitory potency of ammonium sulfate for human angiogenin (IC50 = 123.5 ± 14.9 mm) is comparable to that previously reported for ...

Collagen from the marine sponges Axinella cannabina and Suberites carnosus: Isolation and morphological, biochemical, and biophysical characterization

Tziveleka L.-A., Ioannou E., Tsiourvas D., Berillis P., Foufa E., Roussis V. (2017)

In search of alternative and safer sources of collagen for biomedical applications, the marine demosponges Axinella cannabina and Suberites carnosus, collected from the Aegean and the Ionian Seas, respectively, were ...

Conformational properties of HIV-1 gp120/V3 immunogenic domains

Galanakis, P. A.; Spyroulias, G. A.; Rizos, A.; Samolis, P.; Krambovitis, E. (2005)

Infection of target host cells by the human immunodeficiency virus-1 (HIV-1) is a multi-step process involving a series of conformational changes in the viral gp120 and gp41 proteins. Gp120 binding to the main cell receptor, ...

Dissipation and adsorption of isoproturon, tebuconazole, chlorpyrifos and their main transformation products under laboratory and field conditions

Papadopoulou E.S., Karas P.A., Nikolaki S., Storck V., Ferrari F., Trevisan M., Tsiamis G., Martin-Laurent F., Karpouzas D.G. (2016)

Assessment of dissipation constitutes an integral part of pesticides risk assessment since it provides an estimate of the level and the duration of exposure of the terrestrial ecosystem to pesticides. Within the frame of ...

The effect of fish consumption on macula structure and function of healthy individuals: An OCT and mfERG study

MOSCHOS M.M., NITODA E., LAVARIS A., CHATZIRALLI I.P., ASPROUDIS I., ANDROUDI S., DAMASKOS C., GARMPIS N., KALOGEROPOULOS C. (2018)

OBJECTIVE: The study was designed to investigate the potential effect of fish consumption on macular structure and function of healthy individuals. PATIENTS AND METHODS: The participants were Greek, who used to consume ...

Failure Analysis of Two Ti-Alloy Total Hip Arthroplasty Femoral Stems Fractured In Vivo

Magnissalis, E. A.; Zinelis, S.; Karachalios, T.; Hartofilakidis, G. (2003)

Failure of total hip arthroplasty femoral stems is a serious clinical complication. Even modern metal alloys and designs sometimes suffer such incidents. The reported study aimed at the investigation of the reasons leading ...

Heparan sulfate: biological significance, tools for biochemical analysis and structural characterization

Malavaki, C. J.; Theocharis, A. D.; Lamari, F. N.; Kanakis, I.; Tsegenidis, T.; Tzanakakis, G. N.; Karamanos, N. K. (2011)

Heparan sulfate (HS) and heparin (HP) are functionally important glycosaminoglycans, which interact with a plethora of proteins and participate in several cellular events. They form specific proteoglycans, which are ...

How Many 3D Structures Do We Need to Train a Predictor?

Bagos, P. G.; Tsaousis, G. N.; Hamodrakas, S. J. (2009)

It has been shown that the progress in the determination of membrane protein structure grows exponentially, with approximately the same growth rate as that of the water-soluble proteins. In order to investigate the effect ...

Identification and characterization of tebuconazole transformation products in soil by combining suspect screening and molecular typology

Storck V., Lucini L., Mamy L., Ferrari F., Papadopoulou E.S., Nikolaki S., Karas P.A., Servien R., Karpouzas D.G., Trevisan M., Benoit P., Martin-Laurent F. (2016)

Pesticides generate transformation products (TPs) when they are released into the environment. These TPs may be of ecotoxicological importance. Past studies have demonstrated how difficult it is to predict the occurrence ...

The Impact of Sport Participation on Bone Mass and Geometry in Male Adolescents

Vlachopoulos D., Barker A.R., Williams C.A., Arngrímsson S.A., Knapp K.M., Metcalf B.S., Fatouros I.G., Moreno L.A., Gracia-Marco L. (2017)

Purpose Exercise is an effective approach for developing bone mass and adolescence is a key period to optimize bone health. However, sports-specific training may have different effects on bone outcomes. This study examined ...

In silico investigation of the viroporin E as a vaccine target against SARS-CoV-2

Rouka E., Gourgoulianis K.I., Zarogiannis S.G. (2021)

Viroporins, integral viral membrane ion channel proteins, interact with host-cell proteins deregulating physiological processes and activating inflammasomes. Severity of COVID-19 might be associated with hyperinflammation, ...

Longitudinal determinants of 12-month changes on bone health in adolescent male athletes

Ubago-Guisado E., Vlachopoulos D., Fatouros I.G., Deli C.K., Leontsini D., Moreno L.A., Courteix D., Gracia-Marco L. (2018)

Summary: We identified the determinants of 12-month changes of areal bone mineral density (aBMD), hip geometry and trabecular bone score (TBS) in adolescent male athletes. Changes in region-specific lean mass and the type ...

Optimization of Recombinant Membrane Protein Production in the Engineered Escherichia coli Strains SuptoxD and SuptoxR

Michou M., Kapsalis C., Pliotas C., Skretas G. (2019)

Membrane proteins (MPs) execute a wide variety of critical biological functions in all living organisms and constitute approximately half of current targets for drug discovery. As in the case of soluble proteins, the ...

Predicting alpha helical transmembrane proteins using HMMs

Tsaousis G.N., Theodoropoulou M.C., Hamodrakas S.J., Bagos P.G. (2017)

Alpha helical transmembrane (TM) proteins constitute an important structural class of membrane proteins involved in a wide variety of cellular functions. The prediction of their transmembrane topology, as well as their ...

RNase P: A promising molecular target for the development of new drugs

Tekos, A.; Stathopoulos, C.; Tsambaos, D.; Drainas, D. (2004)

RNase P is an ubiquitous and essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. RNase P activities have been identified in all three kingdoms of life (Bacteria, Archaea, Eukarya). ...

Understanding transboundary air pollution network: Emissions, depositions and spatio-temporal distribution of pollution in European region

Halkos G., Tsilika K. (2019)

The primary objective of this paper is the structural analysis of source-receptor air pollution problems in the EU region. Two views are provided for the analysis: an emission-driven view and a deposition-driven view. ...