Auflistung Nach Schlagwort "genetic association"

ADORA2A rS5760423 and CYP1A2 rs762551 polymorphisms as risk factors for parkinson’s disease

Siokas V., Aloizou A.-M., Tsouris Z., Liampas I., Liakos P., Calina D., Docea A.O., Tsatsakis A., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2021)

Background: Parkinson’s disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both ADORA2A rs5760423 and CYP1A2 rs762551 have been linked to PD, to some extent, but the ...

Advances in Neurodegenerative Diseases

Siokas V., Dardiotis E. (2022)

[No abstract available]

Alpha-synuclein repeat variants and survival in parkinson's disease

Chung, S. J.; Biernacka, J. M.; Armasu, S. M.; Anderson, K.; Frigerio, R.; Aasly, J. O.; Annesi, G.; Bentivoglio, A. R.; Brighina, L.; Chartier-Harlin, M. C.; Goldwurm, S.; Hadjigeorgiou, G.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Krüger, R.; Lesage, S.; Markopoulou, K.; Mellick, G.; Morrison, K. E.; Puschmann, A.; Tan, E. K.; Crosiers, D.; Theuns, J.; Van Broeckhoven, C.; Wirdefeldt, K.; Wszolek, Z. K.; Elbaz, A.; Maraganore, D. M.; Yahalom, G.; Orlev, Y.; Cohen, O. S.; Kozlova, E.; Friedman, E.; Inzelberg, R.; Hassin-Baer, S. (2014)

Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease ...

AMY1 diploid copy number among end-stage renal disease patients

Grammatikopoulou M.G., Gkiouras K., Markaki A.G., Gkouskou K.K., Aivaliotis M., Stylianou K., Bogdanos D.P. (2020)

Purpose: The salivary amylase gene (AMY1) copy number variation (CNV) is increased as a human adaptation to starch-enriched nutritional patterns. The purpose of this study was to evaluate the relationship between AMY1 CNV, ...

Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease

Siokas V., Stamati P., Pateraki G., Liampas I., Aloizou A.-M., Tsirelis D., Nousia A., Sgantzos M., Nasios G., Bogdanos D.P., Dardiotis E. (2022)

A few gene loci that contribute to Alzheimer’s Disease (AD) onset have been identified. Few studies have been published about the relationship between SOD2 rs4880 single nucleotide variant and AD, revealing inconsistent ...

Apolipoprotein E Polymorphism and Left Ventricular Failure in Beta-Thalassemia: A Multivariate Meta-Analysis

Dimou N.L., Pantavou K.G., Bagos P.G. (2017)

Apolipoprotein E (ApoE) is potentially a genetic risk factor for the development of left ventricular failure (LVF), the main cause of death in beta-thalassemia homozygotes. In the present study, we synthesize the results ...

Apolipoprotein ϵ4 allele is associated with frailty syndrome: Results from the hellenic longitudinal investigation of ageing and diet study

Mourtzi N., Ntanasi E., Yannakoulia M., Kosmidis M., Anastasiou C., Dardiotis E., Hadjigeorgiou G., Sakka P., Scarmeas N. (2019)

Apolipoprotein (APOE) ϵ4 allele has been associated with a number of age-related diseases but previous studies failed to identify any link with Frailty syndrome. The aim of the present study is to investigate the association ...

AQP4 tag SNPs in patients with intracerebral hemorrhage in Greek and Polish population

Dardiotis E., Siokas V., Marogianni C., Aloizou A.-M., Sokratous M., Paterakis K., Dardioti M., Grigoriadis S., Brotis A., Kapsalaki E., Fountas K., Jagiella J., Hadjigeorgiou G.M. (2019)

Backround: A relatively small number of genetic variants are implicated to pathophysiology of intracerebral hemorrhage (ICH). Aquaporin-4 (AQP4) has been reported to be implicated in the pathophysiological processes of ICH ...

Assessment of TREM2 rs75932628 variant’s association with Parkinson’s disease in a Greek population and Meta-analysis of current data

Dardiotis E., Rikos D., Siokas V., Aloizou A.-M., Tsouris Z., Sakalakis E., Brotis A.G., Bogdanos D.P., Hadjigeorgiou G.M. (2021)

Background: Α number of genetic variants are considered to confer susceptibility to Parkinson’s disease (PD). Rs75392628 (R47H), a rare variant of TREM2 gene, has been linked to PD, although its role on PD remains conflicting. ...

Association analysis of FTO gene polymorphisms with obesity in Greek adults

Goutzelas Y., Kotsa K., Vasilopoulos Y., Tsekmekidou X., Stamatis C., Yovos J.G., Sarafidou T., Mamuris Z. (2017)

Nowadays, obesity is the greatest scourge worldwide, particularly for the developed countries and is a huge burden for the public health. Over the past decade, GWAS have revealed a number of genes associated with obesity. ...

Association between 9p21–23 Locus and Frailty in a Community-Dwelling Greek Population: Results from the Hellenic Longitudinal Investigation of Ageing and Diet

Mourtzi N., Hatzimanolis A., Xiromerisiou G., Ntanasi E., Georgakis M.K., Ramirez A., Heilmann-Heimbach S., Grenier-Boley B., Lambert J.C., Yannakoulia M., Kosmidis M., Dardiotis E., Hadjigeorgiou G., Sakka P., Scarmeas N. (2022)

Background: Frailty is a complex geriatric syndrome arising from a combination of genetic and environmental factors and is associated with adverse health outcomes and mortality. A recent study reported an association between ...

Association between TLR2/TLR4 gene polymorphisms and COPD phenotype in a Greek cohort [Assoziation zwischen TLR2-/TLR4-Gen-Polymorphismen und COPD-Phänotyp]

Apostolou A., Kerenidi T., Michopoulos A., Gourgoulianis K.I., Noutsias M., Germenis A.E., Speletas M. (2017)

Background: Considering that the innate immune system plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD), we hypothesized that functional single-nucleotide polymorphisms (SNPs) of ...

Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis

Montes, A.; Perez-Pampin, E.; Narváez, J.; Cañete, J. D.; Navarro-Sarabia, F.; Moreira, V.; Fernández-Nebro, A.; Del Carmen Ordóñez, M.; De La Serna, A. R.; Magallares, B.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Joven, B.; Carreira, P.; Gómez-Reino, J. J.; Gonzalez, A. (2014)

OBJECTIVES: We aimed to assess a functional polymorphism in FCGR2A H131R, for association with the treatment response to Fc-containing inhibitors of tumor necrosis factor (TNF). METHODS: A total of 429 biologic-naive ...

Association of IL-10 gene promoter polymorphisms with food allergy susceptibility and serum IL-10 level in a pediatric Caucasian population

Nedelkopoulou N., Taparkou A., Raftopoulou S., Gidaris D., Xinias I., Mavroudi A., Dhawan A., Farmaki E. (2021)

Background: Interleukin 10 has been shown to play a critical role in the regulation of the immune responses in allergic diseases. Aim: To investigate if genetic polymorphisms in the promoter region of the IL-10 gene are ...

Association of ITPA gene polymorphisms with adverse effects of AZA/6-MP administration: a systematic review and meta-analysis

Barba E., Kontou P.I., Michalopoulos I., Bagos P.G., Braliou G.G. (2022)

Azathioprine (AZA) and its metabolite, mercaptopurine (6-MP), are widely used immunosuppressant drugs. Polymorphisms in genes implicated in AZA/6-MP metabolism, reportedly, could account in part for their potential toxicity. ...

Association of KLOTHO Gene Polymorphisms with Knee Osteoarthritis in Greek Population

Tsezou, A.; Furuichi, T.; Satra, M.; Makrythanasis, P.; Ikegawa, S.; Malizos, K. N. (2008)

Based on the fact that klotho-deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that KLOTHO gene plays an important role in calcium/phosphate ...

Association of maternal angiotensin II type 1 and type 2 receptor combination genotypes with susceptibility to early-onset preeclampsia

Satra M., Samara M., Alatsathianos G., Vamvakopoulou D., Baka A., Tsalazidou-Founta T.-M., Sidiropoulos A., Vamvakopoulos K.-O., Garas A., Daponte A., Vamvakopoulos N., Sotiriou S. (2022)

Allelic variations affecting the activity of the maternal renin-angiotensin system may play a role in the development of hypertensive disorders of pregnancy like preeclampsia, its more severe early-onset form, and intrauterine ...

Association of p16 (CDKN2A) polymorphisms with the development of HPV16-related precancerous lesions and cervical cancer in the Greek population

Tsakogiannis D., Moschonas G.D., Bella E., Kyriakopoulou Z., Amoutzias G.D., Dimitriou T.G., Kottaridi C., Markoulatos P. (2018)

The tumor suppressor protein p16 plays a fundamental role in cell cycle regulation and exerts a protective effect against tumor growth. Two different polymorphisms at positions 540 and 580 at the 3′UTR of exon 3 of p16 ...

Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: A case-control study

Qin, J.; Shi, D.; Dai, J.; Zhu, L.; Tsezou, A.; Jiang, Q. (2010)

Previous studies have suggested that leptin works as a key regulator in the pathogenesis of osteoarthritis (OA), and genetic factors modulate OA. This study assessed the contribution of leptin gene (LEP) polymorphism(s) ...

Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson’s Disease in Older Adults

Maraki M.I., Hatzimanolis A., Mourtzi N., Stefanis L., Yannakoulia M., Kosmidis M.H., Dardiotis E., Hadjigeorgiou G.M., Sakka P., Ramirez A., Grenier-Boley B., Lambert J.-C., Heilmann-Heimbach S., Stamelou M., Scarmeas N., Xiromerisiou G. (2021)

Several studies have investigated the association of the Parkinson’s disease (PD) polygenic risk score (PRS) with several aspects of well-established PD. We sought to evaluate the association of PRS with the prodromal stage ...