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Auflistung Nach Schlagwort "CERVICAL-CANCER"

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    • Epigenetic regulation of hTERT promoter in hepatocellular carcinomas 

      Iliopoulos, D.; Satra, M.; Drakaki, A.; Poultsides, G. A.; Tsezou, A. (2009)
      Although hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, the molecular pathogenesis of the disease has not been elucidated. Several studies have shown that telomerase activity and hTERT expression ...

    • Identification of novel E6-E7 sequence variants of human papillomavirus 16 

      Tsakogiannis, D.; Kyriakopoulou, Z.; Amoutzias, G.; Ruether, I. G. A.; Dimitriou, T. G.; Panotopoulou, E.; Markoulatos, P. (2013)
      The rate of evolution of the human papillomavirus 16 (HPV16) genome is low. However, the ability of the E6 oncoprotein to interact with distinct p53 variants causes selective pressure on the E6 gene. In addition, intratypic ...

    • Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women 

      Tsakogiannis, D.; Papadopoulou, A.; Kontostathi, G.; Ruether, I. G. A.; Kyriakopoulou, Z.; Dimitriou, T. G.; Orfanoudakis, G.; Markoulatos, P. (2013)
      Human papillomavirus type 16 (HPV16) non-European variants have been associated with persistent infection and cervical cancer development, while the L83V variant of the E6 gene has been correlated with the progression of ...

    • Sequence-based genotyping HPV L1 DNA and RNA transcripts in clinical specimens 

      Satra, M.; Vamvakopoulou, D. N.; Sioutopoulou, D. O.; Kollia, P.; Kiritsaka, A.; Sotiriou, S.; Antonakopoulos, G.; Alexandris, E.; Costantoulakis, P.; Vamvakopoulos, N. C. (2009)
      We developed a direct sequence-based genotyping method to detect single and multiple HPV L1 DNA and RNA types in genital and dermatological specimens. Our method couples PCR amplification of a highly conserved HPV L1 segment ...