Auflistung nach Autor "Wang, S."
Anzeige der Dokumente 1-7 von 7
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Air flow, temperature and humidity patterns in a greenhouse tunnel
Boulard, T.; Wang, S.; Haxaire, R.; Kittas, C.; Papadakis, G.; Mermier, M. (1999)Air distribution and climatic heterogeneity in greenhouses interfere with plants activity and influence largely crop activity and more particularly transpiration and photosynthesis. This is particularly true for the tunnel, ... -
Convective and ventilation transfers in greenhouses, Part 1: the greenhouse considered as a perfectly stirred tank
Roy, J. C.; Boulard, T.; Kittas, C.; Wang, S. (2002)In this paper, the characterization and modelling of the most relevant convective transfers contributing to the elaboration of the greenhouse climate are reviewed. Convective transfers include heat and mass transfers between ... -
Convective and ventilation transfers in greenhouses, part 2: Determination of the distributed greenhouse climate
Boulard, T.; Kittas, C.; Roy, J. C.; Wang, S. (2002)In this paper, the characterisation and modelling of the most relevant convective transfers contributing to the description of the distributed greenhouse climate are studied in detail. After a brief review of the equations ... -
Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5- dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors
McIntyre, N. A.; McInnes, C.; Griffiths, G.; Barnett, A. L.; Kontopidis, G.; Slawin, A. M. Z.; Jackson, W.; Thomas, M.; Zheleva, D. I.; Wang, S.; Blake, D. G.; Westwood, N. J.; Fischer, P. M. (2010)Following the recent discovery and development of 2-anilino-4-(thiazol-5- yl)pyrimidine cyclin dependent kinase (CDK) inhibitors, a program was initiated to evaluate related ring-constrained analogues, specifically, 2-methyl- ... -
Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents
Wang, S.; Griffiths, G.; Midgley, C. A.; Barnett, A. L.; Cooper, M.; Grabarek, J.; Ingram, L.; Jackson, W.; Kontopidis, G.; McClue, S. J.; McInnes, C.; McLachlan, J.; Meades, C.; Mezna, M.; Stuart, I.; Thomas, M. P.; Zheleva, D. I.; Lane, D. P.; Jackson, R. C.; Glover, D. M.; Blake, D. G.; Fischer, P. M. (2010)The main difficulty in the development of ATP antagonist kinase inhibitors is target specificity, since the ATP-binding motif is present in many proteins. We introduce a strategy that has allowed us to identify compounds ... -
Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors
Wang, S.; Midgley, C. A.; Scaërou, F.; Grabarek, J. B.; Griffiths, G.; Jackson, W.; Kontopidis, G.; McClue, S. J.; McInnes, C.; Meades, C.; Mezna, M.; Plater, A.; Stuart, I.; Thomas, M. P.; Wood, G.; Clarke, R. G.; Blake, D. G.; Zheleva, D. I.; Lane, D. P.; Jackson, R. C.; Glover, D. M.; Fischer, P. M. (2010)Through cell-based screening of our kinase-directed compound collection, we discovered that a subset of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amines were potent cytotoxic agents against cancer cell lines, suppressed mitotic ... -
Targeting active and inactive CDK2 differential binding inhibitors
Kontopidis, G.; McInnes, C.; Pandalaneni, S.; McNae, I.; Gibson, D.; Mezna, M.; Thomas, M.; Wood, G.; Wang, S.; Walkinshaw, M.; Fischer, P. (2008)