Auflistung nach Autor "Premnath, P. N."
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Efficient soluble expression of active recombinant human cyclin A2 mediated by E. coli molecular chaperones
Grigoroudis, A. I.; McInnes, C.; Premnath, P. N.; Kontopidis, G. (2015)Bacterial expression of human proteins continues to present a critical challenge in protein crystallography and drug design. While human cyclin A constructs have been extensively characterized in complex with cyclin dependent ... -
Iterative Conversion of Cyclin Binding Groove Peptides into Drug like CDK Inhibitors with Antitumor Activity
Premnath, P. N.; Craig, S. N.; Liu, S.; Anderson, E. L.; Grigoroudis, A. I.; Kontopidis, G.; Perkins, T. L.; Wyatt, M. D.; Pittman, D. L.; McInnes, C. (2015)The cyclin groove is an important recognition site for substrates of the cell cycle cyclin dependent kinases and provides an opportunity for highly selective inhibition of kinase activity through a non-ATP competitive ... -
Optimization of Non-ATP Competitive CDK/Cyclin Groove Inhibitors through REPLACE-Mediated Fragment Assembly
Liu, S.; Premnath, P. N.; Bolger, J. K.; Perkins, T. L.; Kirkland, L. O.; Kontopidis, G.; McInnes, C. (2013)A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational ...