Auflistung nach Autor "Kontou, M."
Anzeige der Dokumente 1-11 von 11
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3 '-Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why
Manta, S.; Xipnitou, A.; Kiritsis, C.; Kantsadi, A. L.; Hayes, J. M.; Skamnaki, V. T.; Lamprakis, C.; Kontou, M.; Zoumpoulakis, P.; Zographos, S. E.; Leonidas, D. D.; Komiotis, D. (2012)Glycogen phosphorylase is a molecular target for the design of potential hypoglycemic agents. Structure-based design pinpointed that the 3'-position of glucopyranose equipped with a suitable group has the potential to form ... -
The C-terminal Region of HPNAP Activates Neutrophils and Promotes Their Adhesion to Endothelial Cells
Kottakis, F.; Befani, C.; Asiminas, A.; Kontou, M.; Koliakos, G.; Choli-Papadopoulou, T. (2009)Entire Helicobacter Pylori Neutrophil Activated Protein (HPNAP) and its truncated forms NH(2)-terminal region HPNAP(1-57) and C-terminal region HPNAP(58-144) after cloning into pET29c vector, purification and removal of ... -
Flavonoid Glycosides Isolated from Unique Legume Plant Extracts as Novel Inhibitors of Xanthine Oxidase
Spanou, C.; Veskoukis, A. S.; Kerasioti, T.; Kontou, M.; Angelis, A.; Aligiannis, N.; Skaltsounis, A. L.; Kouretas, D. (2012)Legumes and the polyphenolic compounds present in them have gained a lot of interest due to their beneficial health implications. Dietary polyphenolic compounds, especially flavonoids, exert antioxidant properties and are ... -
Inhibitor design for ribonuclease A: the binding of two 5 '-phosphate uridine analogues
Tsirkone, V. G.; Dossi, K.; Drakou, C.; Zographos, S. E.; Kontou, M.; Leonidas, D. D. (2009)In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5'-phosphate (U5P) and uridine 5'-diphosphate ... -
Molecular cloning and biochemical characterization of VIM-12, a novel hybrid VIM-1/VIM-2 metallo-beta-lactamase from a Klebsiella pneumoniae clinical isolate, reveal atypical substrate specificity
Kontou, M.; Pournaras, S.; Kristo, I.; Ikonomidis, A.; Maniatis, A. N.; Stathopoulos, C. (2007)Metallo-beta-lactamases (MBLs) are considered an emerging family of Zn2+-dependent enzymes that significantly contribute to the resistance of many nosocomial pathogens against beta-lactam antimicrobials. Since these ... -
Molecular cloning and biochemical characterization of VIM-12, a novel hybrid VIM-1/VIM-2 metallo-beta-lactamase from a Klebsiella pneumoniae clinical isolate, reveals atypical substrate specificity
Kontou, M.; Pournaras, S.; Kristo, I.; Ikonomidis, A.; Maniatis, A. N.; Stathopoulos, C. (2008) -
Natural agents against neutrophil involvement in H.Pylori induced chronic gastritis
Pendas, S.; Kottakis, F.; Asiminas, A.; Kontou, M.; Befani, C.; Koliakos, G.; Choli-Papadopoulou, T. (2010)Helicobacter pylori infection is one of the widely spread human infections and the major risk for peptic ulcer disease, and gastric cancer and cause for chronic gastric inflammation. The major virulence factors in the ... -
Patterns of variability at the major histocompatibility class I and class II loci in populations of the endangered cyprinid Ladigesocypris ghigii
Moutou, K. A.; Mamuris, Z.; Firme, T.; Kontou, M.; Sarafidou, T.; Stoumboudi, M. T. (2011)The patterns of MHC diversity were studied at UAA and DAB1 loci and the two domains involved in the recognition of antigenic peptides (alpha 2 and beta 1, respectively) in eight Ladigesocypris ghigii populations inhabiting ... -
The s-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b
Kantsadi, A. L.; Hayes, J. M.; Manta, S.; Skamnaki, V. T.; Kiritsis, C.; Psarra, A. M. G.; Koutsogiannis, Z.; Dimopoulou, A.; Theofanous, S.; Nikoleousakos, N.; Zoumpoulakis, P.; Kontou, M.; Papadopoulos, G.; Zographos, S. E.; Komiotis, D.; Leonidas, D. D. (2012)C5 halogen substituted glucopyranosyl nucleosides (1-(beta-D-glucopyranosyl)-5-X-uracil; X=Cl, Br, I) have been discovered as some of the most potent active site inhibitors of glycogen phosphorylase (GP), with respective ... -
Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice
Kontou, M.; Govindasamy, L.; Nam, H. J.; Bryant, N.; Llamas-Saiz, A. L.; Foces-Foces, C.; Hernando, E.; Rubio, M. P.; McKenna, R.; Almendral, J. M.; Agbandje-McKenna, M. (2005)Two strains of the parvovirus minute virus of mice (MVM), the immunosuppressive (MVMi) and the prototype (MVMp) strains, display disparate in vitro tropism and in vivo pathogenicity. We report the crystal structures of ... -
Studies on the Essential Intramolecular Interaction Between the A1 and A2 Domains of von Willebrand Factor
Karoulia, Z.; Papadopoulos, G.; Nomikos, M.; Thanassoulas, A.; Papadopoulou, T. C.; Nounesis, G.; Kontou, M.; Stathopoulos, C.; Leonidas, D. D. (2013)Haemostasis depends on the balanced participation of von Willebrand factor (vWF), a large multimeric and multidomain glycoprotein with essential role during the initial steps of blood clotting. Mature vWF circulates in ...