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Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study
(2017)Background: The prevalence of dementia varies around the world, potentially contributed to by international differences in rates of age-related cognitive decline. Our primary goal was to investigate how rates of age-related ... -
AGREEing on Guidelines for Nutrition Management of Adult Severe Burn Patients
(2019)Background: Severe burns are associated with a plethora of profound metabolic, immunologic, and physiologic responses, demanding prompt and adequate management. The objective of the present study was to review, compare, ... -
An Agrobacterium rhizogenes mediated hairy root transformation protocol for fenugreek
(2020)• This work describes a protocol for hairy root transformation of the medicinal crop legume fenugreek (Trigonella foenum-graecum L.). Hairy root plant transformation mediated by Agrobacterium rhizogenes is an established ... -
Aiming towards hepatitis C virus elimination in Greece
(2019)There are estimated to be 74,000-134,000 patients living with chronic hepatitis C in Greece, but only 20-30% of them are aware of their disease status. In July 2017, the Hellenic National Plan for Hepatitis C was announced ... -
Alanyl-glutamine restores tight junction organization after disruption by a conventional peritoneal dialysis fluid
(2020)Understanding and targeting the molecular basis of peritoneal solute and protein transport is essential to improve peritoneal dialysis (PD) efficacy and patient outcome. Supplementation of PD fluids (PDF) with alanyl-glutamine ... -
Alcoholic liver disease and autoimmune hepatitis: Sometimes a closer look under the surface is needed
(2021)Aims: Differential diagnosis of autoimmune hepatitis (AIH) incorporates various liver diseases, including alcoholic liver disease (ALD). We report on clinical, laboratory and outcome characteristics of AIH patients who ... -
Aldehyde levels in e-cigarette aerosol: Findings from a replication study and from use of a new-generation device
(2018)Purpose A recent study identified high aldehyde emissions from e-cigarettes (ECs), that when converted to reasonable daily human EC liquid consumption, 5 g/day, gave formaldehyde exposure equivalent to 604–3257 tobacco ... -
Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction
(2018)Purpose: Mitochondrial reactive oxygen species (ROS) overproduction in capillary endothelial cells is a prerequisite for the development of diabetic nephropathy. Inhibition of xanthine oxidase, another ROS generator, ... -
Almond and walnut shell-derived biochars affect sorption-desorption, fractionation, and release of phosphorus in two different soils
(2020)Effective soil phosphorus (P) management requires higher level of knowledge concerning its sorption-desorption, fractionation, and release, as well as its interactions with soil amendments including biochar (BC). The purpose ... -
Alterations in hearing function of patients with glucose disorders
(2019)Objective: To study the prevalence of hearing impairment in patients with various glucose disorders. Patients and methods: A total of 499 individuals were studied, 51 patients with type 1 (TIDM), 188 patients with type 2 ... -
Alterations in xenobiotic-metabolizing enzyme activities across menstrual cycle in healthy volunteers
(2019)The purpose of the study was to determine whether the in vivo activities of drug-metabolizing enzymes CYP1A2 and CYP2A6, xanthine oxidase (XO), and N-acetyltransferase-2 (NAT2) vary across the menstrual cycle. Forty-two ... -
Altered activity of xenobiotic detoxifying enzymes at menopause – A cross-sectional study
(2020)Xenobiotic metabolism at menopause is an under-investigated topic, albeit women spend one-third of their life in the postmenopausal period. The present study examined the effect of menopause on the in vivo activities of ... -
Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis
(2022)Background and Aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in ... -
Altitude-dependent prevalence of canine granulocytic anaplasmosis in Romania
(2017)Canine granulocytic anaplasmosis (CGA) is an important tick-borne disease with worldwide distribution. The importance of this disease resides in the ability of Anaplasma phagocytophilum to infect humans and several animal ... -
aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis
(2020)Background & Aims: Hepatocellular carcinoma (HCC) is the leading cause of death in patients with chronic hepatitis. In this international collaboration, we sought to develop a global universal HCC risk score to predict the ... -
Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease
(2018)The MHC class II region in humans is highly polymorphic. Each MHC molecule is formed by an α and a β chain, produced by different genes, creating an antigen-binding groove. In the groove there are several pockets into which ... -
Amiodarone plus Ranolazine for Conversion of Post-Cardiac Surgery Atrial Fibrillation: Enhanced Effectiveness in Reduced Versus Preserved Ejection Fraction Patients
(2018)Purpose: Ranolazine (RAN) added to amiodarone (AMIO) has been shown to accelerate termination of postoperative atrial fibrillation (POAF) following coronary artery bypass surgery in patients without heart failure (HF). ... -
Ammonia-induced inhibition of manure-based continuous biomethanation process under different organic loading rates and associated microbial community dynamics
(2021)Three Continuously Stirred Tank Reactors (CTSRs) were operating at steady state conditions with Organic Loading Rates (OLR) of 2.09, 3.024 and 4.0 g VS L−1 d−1. Glucose was used as the sole factor for increasing the OLR, ... -
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
(2019)AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at ... -
AMY1 diploid copy number among end-stage renal disease patients
(2020)Purpose: The salivary amylase gene (AMY1) copy number variation (CNV) is increased as a human adaptation to starch-enriched nutritional patterns. The purpose of this study was to evaluate the relationship between AMY1 CNV, ...