Sfoglia per Autore "Paraskeva, E."
Items 21-40 di 40
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Identification of a phosphorylation-dependent nuclear export signal in human hypoxia inducible factor HIF-1 alpha
Mylonis, I.; Chachami, G.; Paraskeva, E.; Simos, G. (2007) -
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Mylonis, I.; Chachami, G.; Samiotaki, M.; Panayotou, G.; Paraskeva, E.; Kalousi, A.; Georgatsou, E.; Bonanou, S.; Simos, G. (2006)Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible subunit, HIF-1α, involves several post-translational modifications. ... -
The inflammatory mediator tumor necrosis factor alpha (TNF alpha) has cell type-dependent effects on hypoxia-inducible factor 1 (HIF-1)
Triantafyllou, E. A.; Tsapournioti, S.; Mylonis, I.; Simos, G.; Molyvdas, P. A.; Paraskeva, E. (2014) -
Inhaled insulin does not trigger lung inflammation and airway remodelling
Papagianni, M.; Hatziefthimiou, A.; Chachami, G.; Gourgoulianis, K.; Molyvdas, P. A.; Paraskeva, E. (2009) -
Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells
Papagianni, M.; Hatziefthimiou, A.; Chachami, G.; Gourgoulianis, K.; Molyvdas, P. A.; Paraskeva, E. (2007)Insulin regulates glucose metabolism and activates cell growth. As the respiratory system is an alternative route for insulin administration in patients with diabetes mellitus, we studied the effect of insulin on rabbit ... -
Investigation of hepcidin secretion in human hepatocytes
Chachami, G.; Braliou, G.; Paraskeva, E.; Simos, G. (2008) -
Long-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells
Stamatiou, R.; Paraskeva, E.; Vasilaki, A.; Mylonis, I.; Molyvdas, P. A.; Gourgoulianis, K.; Hatziefthimiou, A. (2014)Background: Chronic airway diseases, like asthma or COPD, are characterized by excessive acetylcholine release and airway remodeling. The aim of this study was to investigate the long-term effect of muscarinic agonists on ... -
Low Serum Hepcidin in Patients with Autoimmune Liver Diseases
Lyberopoulou, A.; Chachami, G.; Gatselis, N. K.; Kyratzopoulou, E.; Saitis, A.; Gabeta, S.; Eliades, P.; Paraskeva, E.; Zachou, K.; Koukoulis, G. K.; Mamalaki, A.; Dalekos, G. N.; Simos, G. (2015)Hepcidin, a liver hormone, is important for both innate immunity and iron metabolism regulation. As dysfunction of the hepcidin pathway may contribute to liver pathology, we analysed liver hepcidin mRNA and serum hepcidin ... -
Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro
Apostolidou, E.; Paraskeva, E.; Gourgoulianis, K.; Molyvdas, P. A.; Hatzoglou, C. (2012)Background: Matrix metalloproteinases (MMPs) 2 and 9 are two gelatinase members which have been found elevated in exudative pleural effusions. In endothelial cells these MMPs increase paracellular permeability via the ... -
The mitogenic effect of testosterone and 17 beta-estradiol on airway smooth muscle cells
Stamatiou, R.; Paraskeva, E.; Papagianni, M.; Molyvdas, P. A.; Hatziefthimiou, A. (2011)Airway disease distribution and/or severity exhibit sex differences suggesting that sex hormones are involved in the respiratory system physiology and pathophysiology. The implication of airway smooth muscle cells (ASMCs) ... -
Non-genomic effect of testosterone on airway smooth muscle
Kouloumenta, V.; Hatziefthimiou, A.; Paraskeva, E.; Gourgoulianis, K.; Molyvdas, P. A. (2006)Background and purpose: Recent studies on blood vessels have provided evidence that testosterone may exert direct effects on smooth muscle. However, an acute effect on airway reactivity has not been shown yet. The aim of ... -
Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera
Chachami, G.; Lyberopoulou, A.; Kalousi, A.; Paraskeva, E.; Pantopoulos, K.; Simos, G. (2013)Hepcidin, a hepatic hormone, regulates serum iron levels by controlling both intestinal iron absorption and iron release from macrophages. Although transcription of hepcidin is controlled by diverse stimuli, it remains ... -
Regulation of HIF-1alpha activity in airway smooth muscle cells: the role of cobalt and serum
Chachami, G.; Simos, G.; Bonanou, S.; Molyvdas, P. A.; Paraskeva, E. (2005) -
Sexual dimorphism in airway responsiveness to sex hormones in rabbits
Kouloumenta, V.; Hatziefthimiou, A.; Paraskeva, E.; Gourgoulianis, K.; Molyvdas, P. A. (2007) -
TNF alpha induces expression of HIF-1 mRNA and protein but inhibits hypoxic stimulation of HIF-1 alpha transcriptional activity in airway smooth muscle cells
Tsapournioti, S.; Mylonis, I.; Hatziefthimiou, A.; Ioannou, M. G.; Stamatiou, R.; Koukoulis, G. K.; Simos, G.; Molyvdas, P. A.; Paraskeva, E. (2013)Airway smooth muscle cells (ASMCs) participate in tissue remodeling characteristic of airway inflammatory diseases like asthma. Inflammation and hypoxia pathways are often interconnected and the regulatory subunit of the ... -
Transport of hypoxia-inducible factor HIF-1 alpha into the nucleus involves importins 4 and 7
Chachami, G.; Paraskeva, E.; Mingot, J. M.; Braliou, G. G.; Gorlich, D.; Simos, G. (2009)Hypoxia-inducible transcription factor 1 (HIF-1) mediates the cellular response to hypoxia. HIF-1 activity is controlled via the synthesis, degradation or intracellular localization of its alpha subunit. HIF-1 alpha contains ... -
Upregulation of VEGF expression is associated with accumulation of HIF-1 alpha in the skin of naive scleroderma patients
Ioannou, M.; Pyrpasopoulou, A.; Simos, G.; Paraskeva, E.; Nikolaidou, C.; Venizelos, I.; Koukoulis, G.; Aslanidis, S.; Douma, S. (2013)Systemic sclerosis is a disease hallmarked by microangiopathy; the enlargement and leakage of skin capillaries in active stages develops into extensive avascular areas, clinically associated with severe tissue hypoxia and ... -
Validated analysis of HIF-1 alpha expression in cancer cells using a controlled and comparative immunoassay
Ioannou, M.; Mylonis, I.; Kouvaras, E.; Papamichali, R.; Daponte, A.; Paraskeva, E.; Simos, G.; Koukoulis, G. K. (2010)The immunoreactivity of hypoxia inducible factor 1 alpha (HIF-1 alpha) has been considered a reliable indicator of the HIF-1 pathway activation in tissue hypoxia. However, HIF-1 alpha immunoreactivity has been evaluated ... -
Validated analysis of HIF-1α expression in cancer cells using a controlled and comparative immunoassay
Ioannou, M.; Mylonis, I.; Kouvaras, E.; Papamichali, R.; Daponte, A.; Paraskeva, E.; Simos, G.; Koukoulis, G. K. (2010)The immunoreactivity of hypoxia inducible factor 1 α (HIF-1α) has been considered a reliable indicator of the HIF-1 pathway activation in tissue hypoxia. However, HIF-1α immunoreactivity has been evaluated with different ... -
Y-box protein-1 is a master-switch for hypoxia-dependent gene regulation
Rauen, T.; Frye, B. C.; En-Nia, A.; Simos, G.; Paraskeva, E.; Mertens, P. R. (2006)