Browsing by Author "Eleftheriadis, T."
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Does hepcidin affect erythropoiesis in hemodialysis patients?
Eleftheriadis, T.; Kartsios, C.; Liakopoulos, V.; Antoniadi, G.; Ditsa, M.; Papadopoulos, C.; Anifandis, G.; Skirta, A.; Markala, D.; Stefanidis, I. (2006)Introduction: Prohepcidin is the precursor of hepcidin, a liver-derived peptide involved in iron metabolism by blocking its intestinal absorption and its release by the reticuloendothelial system. Iron overload and ... -
Effect of 1-year oral alpha-tocopherol administration on anticardiolipin antibodies in hemodialysis patients
Antoniadi, G.; Eleftheriadis, T.; Liakopoulos, V.; Kakasi, E.; Vayonas, G.; Kortsaris, A.; Vargemezis, V. (2005)Background. Anticardiolipin antibodies (ACA) have been related to an increased incidence of thrombotic episodes and atherosclerosis progression. ACA levels are elevated in hemodialysis (HD) patients. Atheroembolic episodes ... -
Effect of sodium-potassium pump inhibition by ouabain on the permeability of isolated visceral sheep peritoneum
Zarogiannis, S.; Liakopoulos, V.; Hatzoglou, C.; Kourti, P.; Vogiatzidis, K.; Potamianos, S.; Eleftheriadis, T.; Gourgoulianis, K.; Molyvdas, P. A.; Stefanidis, I. (2007)The permeability for small solutes and the ultrafiltration capacity of the peritoneum are essential for effective peritoneal dialysis (PD) treatment. Elucidation of the factors that regulate these two properties is therefore ... -
Endothelin-1 Acutely Reduces the Permeability of Visceral Sheep Peritoneum In Vitro Through Both Endothelin-A and Endothelin-B Receptors
Kourti, P.; Zarogiannis, S. G.; Liakopoulos, V.; Karioti, A.; Eleftheriadis, T.; Hatzoglou, C.; Gourgoulianis, K.; Molyvdas, P. A.; Stefanidis, I. (2013)Mesothelium is an important part of the peritoneal barrier for water and ion transport, essential for effective peritoneal dialysis (PD). Peritoneal fibrosis has been associated with PD treatment failure. Endothelin-1 ... -
Endothelin-1 plasma levels in hemodialysis treatment - The influence of type 2 diabetes
Liakopoulos, V.; Wurth, P.; Mertens, P. R.; Eleftheriadis, T.; Kourti, P.; Voliotis, G.; Heintz, B.; Koukoulis, G. N.; Stefanidis, I. (2005)In patients on chronic hemodialysis the prevalence of atherosclerosis is increased and is by far the leading cause of morbidity and mortality. Endothelin-1, an endothelium-derived peptide with vasoconstrictive and mitogenic ... -
Epigenetic Mechanisms and Kidney Diseases
Liakopoulos, V.; Georgianos, P. I.; Eleftheriadis, T.; Sarafidis, P. A. (2011)In recent years, molecular research has brought to light a series of mechanisms involved in the regulation of gene function without altering the DNA sequence. These mechanisms are described with the term "epigenetics" and ... -
The existence of two types of proteasome, the constitutive proteasome and the immunoproteasome, may serve as another layer of protection against autoimmunity
Eleftheriadis, T. (2012)Negative selection of CD8 single positive thymocytes is based on the presentation through the major histocompatibility complex (MHC) class I pathway of peptides derived from degradation of self-proteins by the constitutive ... -
Expression of transforming growth factor-beta receptor 11 mRNA in cyclosporine-induced gingival overgrowth
Stefanidou, V.; Liakopoulos, V.; Eleftheriadis, T.; Anifandis, G.; Mertens, P. R.; Kanelaki, E.; Stefanidis, I. (2006)Gingival overgrowth (GO), characterized by increased cellular and extracellular matrix components in gingival tissue, is a frequent side effect of cyclosporine (CsA). In previous studies, elevated levels of transforming ... -
Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2014)Hepatitis B virus (HBV) is a major global health problem. Despite the success of the general measures against blood transmitted infections in hemodialysis (HD) units, the prevalence of HBV infection among the HD patients ... -
Factors affecting quality of sleep in dialysis patients: Preliminary polysomnographic evidence
Liakopoulos, V.; Sakkas, G. K.; Giannaki, C. D.; Giannopoulou, M.; Eleftheriadis, T.; Stefanidis, I. (2008) -
Ferroportin in monocytes of hemodialysis patients and its associations with hepcidin, inflammation, markers of iron status and resistance to erythropoietin
Eleftheriadis, T.; Pissas, G.; Remoundou, M.; Filippidis, G.; Antoniadi, G.; Oustampasidou, N.; Liakopoulos, V.; Stefanidis, I. (2014)Disturbed iron homeostasis contributes to resistance to recombinant human erythropoietin (rHuEpo) in hemodialysis (HD) patients. Increased hepcidin, which downregulates the iron exporter ferroportin, has been incriminated. ... -
Gastric Antral Vascular Ectasia (Watermelon Stomach) in Patients With ESRD
Stefanidis, I.; Liakopoulos, V.; Kapsoritakis, A. N.; Ioannidis, I.; Eleftheriadis, T.; Mertens, P. R.; Winograd, R.; Vamvaka, E.; Psychos, A. K.; Potamianos, S. P. (2006)In 1989, Navab et al suggested that watermelon stomach often is observed in patients with chronic renal insufficiency. On the basis of this and some later reports, an etiopathogenetic association between the 2 disorders ... -
Gross calcification of the small bowel in a continuous ambulatory peritoneal dialysis patient with sclerosing peritonitis
Poultsidi, A.; Liakopoulos, V.; Eleftheriadis, T.; Zarogiannis, S.; Bouchlariotou, S.; Stefanidis, I. (2006)We present here the case of a continuous ambulatory peritoneal dialysis (CAPD) patient who developed sclerosing calcifying peritonitis with gross macroscopic calcification of the small bowel, a rare and life-threatening ... -
Hemodialysis procedure does not affect the levels of sICAM-1 and sVCAM-1 in patients with end stage renal disease
Liakopoulos, V.; Eleftheriadis, T.; Kyropoulos, T.; Voliotis, G.; Potamianos, S.; Zengos, N.; Stefanidis, I.; Heintz, B. (2005)Atherosclerosis is by far the leading cause of mortality and morbidity in patients with end stage renal disease undergoing chronic hemodialysis (HD). Vascular endothelial cell adhesion molecules like the intercellular ... -
Impact of proton pump inhibitor use on magnesium homoeostasis: a cross-sectional study in a tertiary emergency department
Lindner, G.; Funk, G. C.; Leichtle, A. B.; Fiedler, G. M.; Schwarz, C.; Eleftheriadis, T.; Pasch, A.; Mohaupt, M. G.; Exadaktylos, A. K.; Arampatzis, S. (2014)BackgroundTo date, the use of proton pump inhibitors (PPIs) has been associated with a low risk of hypomagnesaemia and associated adverse outcomes. We hypothesised that a better risk estimate could be derived from a large ... -
Increased Plasma Angiogenin Level is Associated and May Contribute to Decreased T-Cell Zeta-Chain Expression in Hemodialysis Patients
Eleftheriadis, T.; Kartsios, C.; Pissas, G.; Liakopoulos, V.; Antoniadi, G.; Galaktidou, G.; Stefanidis, I. (2013)Hemodialysis (HD) patients are characterized by impaired T-cell function at least in part because of T-cell zeta-chain downregulation due to inflammation. Angiogenin responds as an acute phase reactant, is increased in HD ... -
Increased visfatin in hemodialysis patients is associated with decreased demands for recombinant human erythropoietin
Eleftheriadis, T.; Pissas, G.; Remoundou, M.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2013)Background: Studies detected an association between visfatin and markers of iron metabolism in patients with insulin resistance. In this study, such a relation was evaluated in hemodialysis (HD) patients. Also relations ... -
Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2015)Indoleamine 2,3-dioxygenase (IDO) is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4+ T cells. One mechanism is through the inhibition of aerobic glycolysis. Another prerequisite for T-cell ... -
Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Spanoulis, A.; Liakopoulos, V.; Stefanidis, I. (2014)Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53 also alters these cellular processes with similar results. The ... -
The Indoleamine 2,3-dioxygenase Inhibitor 1-methyl-tryptophan Suppresses Mitochondrial Function, Induces Aerobic Glycolysis and Decreases Interleukin-10 Production in Human Lymphocytes
Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Liakopoulos, V.; Dafopoulou, K.; Pournaras, S.; Koukoulis, G.; Stefanidis, I. (2012)Background: Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity. It is known that IDO induces T-cell differentiation to regulatory T-cells (Treg) through tryptophan depletion and/or kynurenine pathway products. ...