Auflistung nach Autor "Simos, G."
Anzeige der Dokumente 21-40 von 69
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Determination and significance of serum hepcidin and liver hepcidin mRNA levels in patients with hepatopathies
Lyberopoulou, A.; Chachami, G.; Gatselis, N. K.; Eliades, P.; Paraskeva, E.; Zachou, K.; Mamalaki, A.; Dalekos, G. N.; Simos, G. (2012) -
The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
Mylonis, I.; Lakka, A.; Tsakalof, A.; Simos, G. (2010)Hepatocellular carcinoma (HCC) is characterized by high mortality rates and resistance to conventional treatment. HCC tumors usually develop local hypoxia, which stimulates proliferation of cancer cells and renders them ... -
Differential regulation of hypoxia inducible factor 1 alpha (HIF-1 alpha) expression and HeLa cell survival and proliferation by hypoxia, desferrioxamine, cobalt and quercetin: the role of iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2005) -
Down-regulation of hepcidin production in patients with autoimmune liver diseases
Gatselis, N.; Lyberopoulou, A.; Zachou, K.; Chachami, G.; Eliades, P.; Gabeta, S.; Paraskeva, E.; Mamalaki, A.; Koukoulis, G. K.; Simos, G.; Dalekos, G. N. (2014) -
eIF2 alpha Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1 alpha
Papadakis, A. I.; Paraskeva, E.; Peidis, P.; Muaddi, H.; Li, S. Y.; Raptis, L.; Pantopoulos, K.; Simos, G.; Koromilas, A. E. (2010)Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1 alpha (HIF-1 alpha), cells also respond to hypoxia by ... -
The eIF2 alpha kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1 alpha expression
Papadakis, A. I.; Paraskeva, E.; Peidis, P.; Muaddi, H.; Raptis, L.; Pantopoulos, K.; Simos, G.; Koromilas, E. (2010) -
Enzyme-linked immunosorbent assay for pharmacological studies targeting hypoxia-inducible factor 1 alpha
Formento, J. L.; Berra, E.; Ferrua, B.; Magne, N.; Simos, G.; Brahimi-Horn, C.; Pouyssegur, J.; Milano, G. (2005)Hypoxia-inducible factor 1 (HIF-1) activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions. HIF-1 is, in fact, a heterodimer of two ... -
Epstein-Barr Virus Immortalization of Human B-Cells Leads to Stabilization of Hypoxia-Induced Factor 1 Alpha, Congruent with the Warburg Effect
Darekar, S.; Georgiou, K.; Yurchenko, M.; Yenamandra, S. P.; Chachami, G.; Simos, G.; Klein, G.; Kashuba, E. (2012)Background: Epstein-Barr virus (EBV) encodes six nuclear transformation-associated proteins that induce extensive changes in cellular gene expression and signaling and induce B-cell transformation. The role of HIF1A in ... -
ERK-dependent association of HIF-1 alpha with chromatin via a peptide that can inhibit HIF-1 activity when over-expressed in hepatocellular carcinoma cells
Kourti, M.; Giakoumakis, N. N.; Lygerou, Z.; Simos, G.; Mylonis, I. (2014) -
Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1 alpha and airway responsiveness to ACh
Chachami, G.; Hatziefthimiou, A.; Liakos, P.; Ioannou, M. G.; Koukoulis, G. K.; Bonanou, S.; Molyvdas, P. A.; Simos, G.; Paraskeva, E. (2007)Airway smooth muscle (ASM) cells are characterized by phenotypic plasticity and can switch between differentiated and proliferative phenotypes. In rabbit tracheal ASM cells that had been differentiated in vitro by serum ... -
The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Chachami, G.; Paraskeva, E.; Molyvdas, P. A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2007)Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ... -
Flavonoids induce HIF-1 alpha but impair its nuclear accumulation and activity
Triantafyllou, A.; Mylonis, L.; Simos, G.; Bonanou, S.; Tsakalof, A. (2008)Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the transcription factor HIF-1, which is highly involved in the pathology of diseases associated with tissue hypoxia. In this study we investigated ... -
HIF-1a in colorectal carcinoma: review of the literature
Ioannou, M.; Paraskeva, E.; Baxevanidou, K.; Simos, G.; Papamichali, R.; Papacharalambous, C.; Samara, M.; Koukoulis, G. (2015)Colorectal cancer (CRC) is the third most common cancer worldwide and despite the abundance of molecular pathways and markers continually being reported, the mortality rates remain high. Hypoxia inducible factor 1alpha ... -
HIF-1α in colorectal carcinoma: Review of the literature
Ioannou, M.; Paraskeva, E.; Baxevanidou, K.; Simos, G.; Papamichali, R.; Papacharalambous, C.; Samara, M.; Koukoulis, G. (2015)Colorectal cancer (CRC) is the third most common cancer worldwide and despite the abundance of molecular pathways and markers continually being reported, the mortality rates remain high. Hypoxia inducible f actor lalpha ... -
High serum levels of HIF-1 alpha in psoriatic patients correlate with an over-expression of IL-6
Vasilopoulos, Y.; Sourli, F.; Zafiriou, E.; Klimi, E.; Ioannou, M.; Mamuris, Z.; Simos, G.; Koukoulis, G.; Roussaki-Schulze, A. (2013)Angiogenesis has been considered to be an important step in the initiation and progression of chronic diseases such as psoriasis. The hypoxia inducible factor 1 alpha (HIF-1 alpha), a critical hypoxia-induced factor that ... -
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Mylonis, I.; Sembongi, H.; Befani, C.; Liakos, P.; Siniossoglou, S.; Simos, G. (2012)Adaptation to hypoxia involves hypoxia-inducible transcription factors (HIFs) and requires reprogramming of cellular metabolism that is essential during both physiological and pathological processes. In contrast to the ... -
Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma
Ioannou, M.; Papamichali, R.; Kouvaras, E.; Mylonis, I.; Vageli, D.; Kerenidou, T.; Barbanis, S.; Daponte, A.; Simos, G.; Gourgoulianis, K.; Koukoulis, G. K. (2009)Neoangiogenesis has been documented in small cell lung carcinoma (SCLC). In addition, antiangiogenic therapies are being tested in clinical trials that involve SCLC. However, study of the underlying mechanisms has been ... -
Identification of a phosphorylation-dependent nuclear export signal in human hypoxia inducible factor HIF-1 alpha
Mylonis, I.; Chachami, G.; Paraskeva, E.; Simos, G. (2007) -
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Mylonis, I.; Chachami, G.; Samiotaki, M.; Panayotou, G.; Paraskeva, E.; Kalousi, A.; Georgatsou, E.; Bonanou, S.; Simos, G. (2006)Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible subunit, HIF-1α, involves several post-translational modifications. ... -
Incorporation of the Arc1p tRNA-binding domain to the catalytic core of MetRS can functionally replace the yeast Arc1p-MetRS complex
Karanasios, E.; Boleti, H.; Simos, G. (2008)The catalytic core of methionyl-tRNA synthetase (MetRS) is conserved among all life kingdoms but, depending on species origin, is often linked to noncatalytic domains appended to its N- or C-terminus. These domains usually ...