Mostrar el registro sencillo del ítem
Association of maternal Toll-like receptor-4 alleles with susceptibility to early-onset preeclampsia in central Greece
dc.creator | Vamvakopoulou D.N., Satra M., Fegga A., Kourti M., Sidiropoulos A., Daponte A., Gounaris A., Syrogianopoulos G., Vamvakopoulos N.C., Sotiriou S. | en |
dc.date.accessioned | 2023-01-31T10:25:34Z | |
dc.date.available | 2023-01-31T10:25:34Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1016/j.preghy.2019.09.007 | |
dc.identifier.issn | 22107789 | |
dc.identifier.uri | http://hdl.handle.net/11615/80375 | |
dc.description.abstract | Introduction: Altered maternal inflammatory responses may play a role in the development of hypertensive disorders of pregnancy like preeclampsia, its more severe early-onset form and intrauterine growth restriction. We evaluated the relation of common allelic variants of Toll-like receptor 4 (TLR4), known to impair the inflammatory response, with the susceptibility to early-onset preeclampsia in Central Greece. Methods: We compared the occurrence of TLR4 (Asp299Gly and Thr399Ile) alleles in heterozygous (A/G, C/T) and homozygous (G/G, T/T) states in 84 women with a history of early-onset preeclampsia and 94 age matched controls with a history of only uneventful pregnancies, by direct sequencing. Results: Heterozygous TLR4 allelic variants were more common in women with a history of early-onset preeclampsia than in controls (GA for Asp299Gly: 14.3% vs 6.4% (AA), p = 0.053 & CT for Thr399Ile: 16.7% vs. 6.4% (CC), p = 0.019) and a stronger association was obtained when homozygous allelic carriers were also included (GA/GG for Asp299Gly: 16.7% vs. 6.4% (AA), p = 0.03 & TC/TT for Thr399Ile: 19.0% vs. 6.4% (CC), p = 0.01). Discussion: We recorded association between common TLR4 gene variants and early-onset preeclampsia. Our findings support the involvement of maternal innate immune system in severe hypertensive disorders of pregnancy and point to the potential value of maternal TLR4 polymorphisms as predictors-risk factors of susceptibility to early-onset preeclampsia in Central Greece. © 2019 International Society for the Study of Hypertension in Pregnancy | en |
dc.language.iso | en | en |
dc.source | Pregnancy Hypertension | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072774977&doi=10.1016%2fj.preghy.2019.09.007&partnerID=40&md5=6536c013e73ba5a0fb8870ef8bf61949 | |
dc.subject | aspartic acid | en |
dc.subject | glycine | en |
dc.subject | isoleucine | en |
dc.subject | threonine | en |
dc.subject | toll like receptor 4 | en |
dc.subject | TLR4 protein, human | en |
dc.subject | toll like receptor 4 | en |
dc.subject | adult | en |
dc.subject | allele | en |
dc.subject | Article | en |
dc.subject | controlled study | en |
dc.subject | disease association | en |
dc.subject | disease predisposition | en |
dc.subject | DNA polymorphism | en |
dc.subject | female | en |
dc.subject | fetus | en |
dc.subject | gene | en |
dc.subject | gene sequence | en |
dc.subject | genetic analysis | en |
dc.subject | genetic susceptibility | en |
dc.subject | genetic variability | en |
dc.subject | genotype | en |
dc.subject | Greece | en |
dc.subject | heterozygosity | en |
dc.subject | homozygosity | en |
dc.subject | human | en |
dc.subject | inflammation | en |
dc.subject | innate immunity | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | onset age | en |
dc.subject | preeclampsia | en |
dc.subject | pregnancy | en |
dc.subject | priority journal | en |
dc.subject | protein analysis | en |
dc.subject | risk factor | en |
dc.subject | sequence analysis | en |
dc.subject | TLR4 gene | en |
dc.subject | allele | en |
dc.subject | blood | en |
dc.subject | case control study | en |
dc.subject | Caucasian | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | preeclampsia | en |
dc.subject | prenatal diagnosis | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | Adult | en |
dc.subject | Alleles | en |
dc.subject | Case-Control Studies | en |
dc.subject | European Continental Ancestry Group | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Pre-Eclampsia | en |
dc.subject | Pregnancy | en |
dc.subject | Prenatal Diagnosis | en |
dc.subject | Toll-Like Receptor 4 | en |
dc.subject | Elsevier B.V. | en |
dc.title | Association of maternal Toll-like receptor-4 alleles with susceptibility to early-onset preeclampsia in central Greece | en |
dc.type | journalArticle | en |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |