Εμφάνιση απλής εγγραφής

dc.creatorVamvakopoulou D.N., Satra M., Fegga A., Kourti M., Sidiropoulos A., Daponte A., Gounaris A., Syrogianopoulos G., Vamvakopoulos N.C., Sotiriou S.en
dc.date.accessioned2023-01-31T10:25:34Z
dc.date.available2023-01-31T10:25:34Z
dc.date.issued2019
dc.identifier10.1016/j.preghy.2019.09.007
dc.identifier.issn22107789
dc.identifier.urihttp://hdl.handle.net/11615/80375
dc.description.abstractIntroduction: Altered maternal inflammatory responses may play a role in the development of hypertensive disorders of pregnancy like preeclampsia, its more severe early-onset form and intrauterine growth restriction. We evaluated the relation of common allelic variants of Toll-like receptor 4 (TLR4), known to impair the inflammatory response, with the susceptibility to early-onset preeclampsia in Central Greece. Methods: We compared the occurrence of TLR4 (Asp299Gly and Thr399Ile) alleles in heterozygous (A/G, C/T) and homozygous (G/G, T/T) states in 84 women with a history of early-onset preeclampsia and 94 age matched controls with a history of only uneventful pregnancies, by direct sequencing. Results: Heterozygous TLR4 allelic variants were more common in women with a history of early-onset preeclampsia than in controls (GA for Asp299Gly: 14.3% vs 6.4% (AA), p = 0.053 & CT for Thr399Ile: 16.7% vs. 6.4% (CC), p = 0.019) and a stronger association was obtained when homozygous allelic carriers were also included (GA/GG for Asp299Gly: 16.7% vs. 6.4% (AA), p = 0.03 & TC/TT for Thr399Ile: 19.0% vs. 6.4% (CC), p = 0.01). Discussion: We recorded association between common TLR4 gene variants and early-onset preeclampsia. Our findings support the involvement of maternal innate immune system in severe hypertensive disorders of pregnancy and point to the potential value of maternal TLR4 polymorphisms as predictors-risk factors of susceptibility to early-onset preeclampsia in Central Greece. © 2019 International Society for the Study of Hypertension in Pregnancyen
dc.language.isoenen
dc.sourcePregnancy Hypertensionen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85072774977&doi=10.1016%2fj.preghy.2019.09.007&partnerID=40&md5=6536c013e73ba5a0fb8870ef8bf61949
dc.subjectaspartic aciden
dc.subjectglycineen
dc.subjectisoleucineen
dc.subjectthreonineen
dc.subjecttoll like receptor 4en
dc.subjectTLR4 protein, humanen
dc.subjecttoll like receptor 4en
dc.subjectadulten
dc.subjectalleleen
dc.subjectArticleen
dc.subjectcontrolled studyen
dc.subjectdisease associationen
dc.subjectdisease predispositionen
dc.subjectDNA polymorphismen
dc.subjectfemaleen
dc.subjectfetusen
dc.subjectgeneen
dc.subjectgene sequenceen
dc.subjectgenetic analysisen
dc.subjectgenetic susceptibilityen
dc.subjectgenetic variabilityen
dc.subjectgenotypeen
dc.subjectGreeceen
dc.subjectheterozygosityen
dc.subjecthomozygosityen
dc.subjecthumanen
dc.subjectinflammationen
dc.subjectinnate immunityen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectonset ageen
dc.subjectpreeclampsiaen
dc.subjectpregnancyen
dc.subjectpriority journalen
dc.subjectprotein analysisen
dc.subjectrisk factoren
dc.subjectsequence analysisen
dc.subjectTLR4 geneen
dc.subjectalleleen
dc.subjectblooden
dc.subjectcase control studyen
dc.subjectCaucasianen
dc.subjectgenetic predispositionen
dc.subjectgeneticsen
dc.subjectpreeclampsiaen
dc.subjectprenatal diagnosisen
dc.subjectsingle nucleotide polymorphismen
dc.subjectAdulten
dc.subjectAllelesen
dc.subjectCase-Control Studiesen
dc.subjectEuropean Continental Ancestry Groupen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectPre-Eclampsiaen
dc.subjectPregnancyen
dc.subjectPrenatal Diagnosisen
dc.subjectToll-Like Receptor 4en
dc.subjectElsevier B.V.en
dc.titleAssociation of maternal Toll-like receptor-4 alleles with susceptibility to early-onset preeclampsia in central Greeceen
dc.typejournalArticleen


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