dc.creator | Valente A., Carrillo A.E., Tzatzarakis M.N., Vakonaki E., Tsatsakis A.M., Kenny G.P., Koutedakis Y., Jamurtas A.Z., Flouris A.D. | en |
dc.date.accessioned | 2023-01-31T10:24:40Z | |
dc.date.available | 2023-01-31T10:24:40Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.1016/j.fct.2015.09.018 | |
dc.identifier.issn | 02786915 | |
dc.identifier.uri | http://hdl.handle.net/11615/80346 | |
dc.description.abstract | We investigated the absorption and metabolism pharmacokinetics of a single L-menthol oral versus skin administration and the effects on human thermogenesis and metabolic rate. Twenty healthy adults were randomly distributed into oral (capsule) and skin (gel) groups and treated with 10 mg kg-1 L-menthol (ORALMENT; SKINMENT) or control (lactose capsule: ORALCON; water application: SKINCON) in a random order on two different days. Levels of serum L-menthol increased similarly in ORALMENT and SKINMENT (p > 0.05). L-menthol glucuronidation was greater in ORALMENT than SKINMENT (p < 0.05). Cutaneous vasoconstriction, rectal temperature and body heat storage showed greater increase following SKINMENT compared to ORALMENT and control conditions (p < 0.05). Metabolic rate increased from baseline by 18% in SKINMENT and 10% in ORALMENT and respiratory exchange ratio decreased more in ORALMENT (5.4%) than SKINMENT (4.8%) compared to control conditions (p < 0.05). Levels of plasma adiponectin and leptin as well as heart rate variability were similar to control following either treatment (p > 0.05). Participants reported no cold, shivering, discomfort, stress or skin irritation. We conclude that a single L-menthol skin administration increased thermogenesis and metabolic rate in humans. These effects are minor following L-menthol oral administration probably due to faster glucuronidation and greater blood menthol glucuronide levels. © 2015 Published by Elsevier Ltd. | en |
dc.language.iso | en | en |
dc.source | Food and Chemical Toxicology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946567428&doi=10.1016%2fj.fct.2015.09.018&partnerID=40&md5=98b2eab49a939ec37c7dc014ee6289dc | |
dc.subject | adiponectin | en |
dc.subject | leptin | en |
dc.subject | menthol | en |
dc.subject | glucuronic acid | en |
dc.subject | menthol | en |
dc.subject | menthol glucuronide | en |
dc.subject | absence of side effects | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | body temperature measurement | en |
dc.subject | controlled study | en |
dc.subject | drug absorption | en |
dc.subject | drug metabolism | en |
dc.subject | female | en |
dc.subject | glucuronidation | en |
dc.subject | heart rate variability | en |
dc.subject | human | en |
dc.subject | human experiment | en |
dc.subject | lung gas exchange | en |
dc.subject | male | en |
dc.subject | metabolic rate | en |
dc.subject | normal human | en |
dc.subject | protein blood level | en |
dc.subject | rectum temperature | en |
dc.subject | skin absorption | en |
dc.subject | thermogenesis | en |
dc.subject | vasoconstriction | en |
dc.subject | analogs and derivatives | en |
dc.subject | blood | en |
dc.subject | drug effects | en |
dc.subject | energy metabolism | en |
dc.subject | heat | en |
dc.subject | oral drug administration | en |
dc.subject | perception | en |
dc.subject | randomized controlled trial | en |
dc.subject | skin | en |
dc.subject | skin temperature | en |
dc.subject | thermogenesis | en |
dc.subject | time factor | en |
dc.subject | topical drug administration | en |
dc.subject | vascularization | en |
dc.subject | young adult | en |
dc.subject | Administration, Oral | en |
dc.subject | Administration, Topical | en |
dc.subject | Adult | en |
dc.subject | Energy Metabolism | en |
dc.subject | Female | en |
dc.subject | Glucuronates | en |
dc.subject | Hot Temperature | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Menthol | en |
dc.subject | Perception | en |
dc.subject | Skin | en |
dc.subject | Skin Temperature | en |
dc.subject | Thermogenesis | en |
dc.subject | Time Factors | en |
dc.subject | Young Adult | en |
dc.subject | Elsevier Ltd | en |
dc.title | The absorption and metabolism of a single L-menthol oral versus skin administration: Effects on thermogenesis and metabolic rate | en |
dc.type | journalArticle | en |