HOTAIR as a prognostic predictor for diverse human cancers: A meta- and bioinformatics analysis
dc.creator | Toy H.I., Okmen D., Kontou P.I., Georgakilas A.G., Pavlopoulou A. | en |
dc.date.accessioned | 2023-01-31T10:09:25Z | |
dc.date.available | 2023-01-31T10:09:25Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.3390/cancers11060778 | |
dc.identifier.issn | 20726694 | |
dc.identifier.uri | http://hdl.handle.net/11615/79751 | |
dc.description.abstract | Several studies suggest that upregulated expression of the long non-coding RNA HOX transcript antisense RNA (HOTAIR) is a negative predictive biomarker for numerous cancers. Herein, we performed a meta-analysis to further investigate the prognostic value of HOTAIR expression in diverse human cancers. To this end, a systematic literature review was conducted in order to select scientific studies relevant to the association between HOTAIR expression and clinical outcomes, including overall survival (OS), recurrence-free survival (RFS)/disease-free survival (DFS), and progression-free survival (PFS)/metastasis-free survival (MFS) of cancer patients. Collectively, 53 eligible studies including a total of 4873 patients were enrolled in the current meta-analysis. Pooled hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were calculated to assess the relationship between HOTAIR and cancer patients’ survival. Elevated HOTAIR expression was found to be significantly associated with OS, RFS/DFS and PFS/MFS in diverse types of cancers. These findings were also corroborated by the results of bioinformatics analysis on overall survival. Therefore, based on our findings, HOTAIR could serve as a potential biomarker for the prediction of cancer patient survival in many different types of human cancers. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.language.iso | en | en |
dc.source | Cancers | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070698249&doi=10.3390%2fcancers11060778&partnerID=40&md5=d87ebb55f12180d4c847d61224c6fef9 | |
dc.subject | long untranslated RNA | en |
dc.subject | tumor marker | en |
dc.subject | Article | en |
dc.subject | bioinformatics | en |
dc.subject | cancer patient | en |
dc.subject | cancer prognosis | en |
dc.subject | cancer survival | en |
dc.subject | clinical outcome | en |
dc.subject | diagnostic value | en |
dc.subject | disease association | en |
dc.subject | disease free survival | en |
dc.subject | gene | en |
dc.subject | gene expression | en |
dc.subject | gene overexpression | en |
dc.subject | hazard ratio | en |
dc.subject | HOTAIR gene | en |
dc.subject | human | en |
dc.subject | malignant neoplasm | en |
dc.subject | metastasis free survival | en |
dc.subject | nonhuman | en |
dc.subject | overall survival | en |
dc.subject | prediction | en |
dc.subject | progression free survival | en |
dc.subject | recurrence free survival | en |
dc.subject | MDPI AG | en |
dc.title | HOTAIR as a prognostic predictor for diverse human cancers: A meta- and bioinformatics analysis | en |
dc.type | journalArticle | en |
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