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dc.creatorTouloumi G., Kalpourtzi N., Papastamopoulos V., Paparizos V., Adamis G., Antoniadou A., Chini M., Karakosta A., Makrilakis K., Gavana M., Vantarakis A., Psichogiou M., Metallidis S., Sipsas N.V., Sambatakou H., Hadjichristodoulou C., Voulgari P.V., Chrysos G., Gogos C.A., Chlouverakis G., Tripsianis G., Alamanos Y., Stergiou G., Alexis B., Anna K., Nikos P., Georgia V., Klea K., Maria K., Xenia C., Alexis B., Magda G., Bettina H., Christos H., George R., Ilias N., Koustenis P., Stavros L., Ioannis I., Athanasios R., Stella I., Alexios S., Gikas A., Gogos H.A., Katsarou O., Lazanas M., Panagopoulos P., Paraskevis D., Psychogiou M., Papadopoulos A., Nitsotolis T., Xylomenos G., Marangos M.N., Kouramba A., Kontos A., Lioni A., Tsachouridou O., Kourkounti S., Ganitis A., Barbounakis E., AMACS and EMENOen
dc.date.accessioned2023-01-31T10:09:11Z
dc.date.available2023-01-31T10:09:11Z
dc.date.issued2020
dc.identifier10.1371/journal.pone.0230730
dc.identifier.issn19326203
dc.identifier.urihttp://hdl.handle.net/11615/79740
dc.description.abstractBackground Although combined antiretroviral therapy has substantially improved the prognosis of people living with HIV (PLHIV), mortality remains higher compared to the general population, mainly due to higher prevalence of non-HIV-related comorbidities, including cardiovascular diseases (CVD). We assessed the prevalence of CVD risk and its contributing factors in adult PLHIV versus general population controls in Greece. Settings Cross-sectional comparison of PLHIV (Athens-Multicenter-AIDS-Cohort-Study; AMACS) versus general population controls (National health examination survey; EMENO). Methods All HIV-infected adults with ≥1 measurement of interest (blood pressure, lipids, glucose, weight, height) between 2012-2014 and all EMENO participants (2014-2016) were included. Ten-year total CVD risk was estimated using the Framingham (FRS) or the Systematic Coronary Risk Evaluation (SCORE) equations. Results 5839 PLHIV (median age:41.6 years, 85.4% males) and 4820 controls (median age:48 years, 48.4% males) were included. Adjusting for age, sex and origin, PLHIV were more likely to be current smokers (adjusted OR:1.53 [95% CI:1.35-1.74]) and dyslipidemic (aOR:1.18; [1.04-1.34]), less likely to be obese (aOR:0.44 [0.38-0.52], with no differences in hypertension, diabetes or high (≥20%) FRS but with greater odds of high (≥5%) SCORE (aOR:1.55 [1.05-2.30]). Further adjustment for educational level, anti-HCV positivity and BMI showed higher prevalence of hypertension in PLHIV. Conclusions Despite the relative absence of obesity, PLHIV have higher prevalence of traditional CVD risk factors and higher risk of fatal CVD compared to general population. Regular screening and early management of CVD risk factors in PLHIV should be of high priority for CVD prevention. Copyright: © 2020 Touloumi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.language.isoenen
dc.sourcePLoS ONEen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85082730847&doi=10.1371%2fjournal.pone.0230730&partnerID=40&md5=c3f1c1a86fe82fea46b145abd9fc9468
dc.subjectglucoseen
dc.subjectlipiden
dc.subjectadulten
dc.subjectage distributionen
dc.subjectageden
dc.subjectArticleen
dc.subjectblood pressureen
dc.subjectbody heighten
dc.subjectbody massen
dc.subjectbody weighten
dc.subjectcardiovascular diseaseen
dc.subjectcardiovascular disease assessmenten
dc.subjectcardiovascular risken
dc.subjectcohort analysisen
dc.subjectcontrolled studyen
dc.subjectcross-sectional studyen
dc.subjectcurrent smokeren
dc.subjectdiabetes mellitusen
dc.subjectdyslipidemiaen
dc.subjecteducational statusen
dc.subjectfemaleen
dc.subjectFramingham risk scoreen
dc.subjectglucose blood levelen
dc.subjectGreeceen
dc.subjecthealth surveyen
dc.subjecthepatitis Cen
dc.subjecthumanen
dc.subjectHuman immunodeficiency virus infected patienten
dc.subjectHuman immunodeficiency virus infectionen
dc.subjecthypertensionen
dc.subjectlipid blood levelen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectobesityen
dc.subjectpopulation researchen
dc.subjectprevalenceen
dc.subjectrisk assessmenten
dc.subjectrisk factoren
dc.subjectSystematic Coronary Risk Evaluationen
dc.subjectadolescenten
dc.subjectcardiovascular diseaseen
dc.subjectcase control studyen
dc.subjectcomplicationen
dc.subjectHuman immunodeficiency virus infectionen
dc.subjectmiddle ageden
dc.subjectyoung adulten
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCardiovascular Diseasesen
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHIV Infectionsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRisk Factorsen
dc.subjectYoung Adulten
dc.subjectPublic Library of Scienceen
dc.titleCardiovascular risk factors in HIV infected individuals: Comparison with general adult control population in Greeceen
dc.typejournalArticleen


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