dc.creator | Thomas R.M., Algrain H.A., Ryan E.J., Popojas A., Carrigan P., Abdulrahman A., Carrillo A.E. | en |
dc.date.accessioned | 2023-01-31T10:08:31Z | |
dc.date.available | 2023-01-31T10:08:31Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1007/s11845-016-1478-7 | |
dc.identifier.issn | 00211265 | |
dc.identifier.uri | http://hdl.handle.net/11615/79708 | |
dc.description.abstract | Background: Proposed differences in caffeine metabolism due to the CYP1A2*1F polymorphism have been linked to variations in cardiovascular disease risk. Aims: We examined the influence of a CYP1A2*1F polymorphism on post-exercise heart rate variability (HRV) in response to caffeine intake. Methods: Volunteers were identified as A/A homozygotes (A/A; 4 females and 7 males; age: 25.3 ± 4.1 years; BMI: 25.9 ± 4.4 kg/m2) or C allele carriers (C allele; 3 females and 6 males; age: 25.5 ± 2.8 years; BMI: 26.6 ± 5.0 kg/m2) for participation in a repeated measures, counterbalanced, double-blind, placebo-controlled trial. Participants chewed three pieces of gum containing either caffeine (CAF) (100 mg/piece) or placebo for 5 min. Thereafter, participants cycled for 15 min at 75 % of their peak oxygen consumption. Eight HRV indices computed during 5 min at baseline (BASE), 0–5 min after exercise (POST1), and 5–10 min after exercise (POST2) were used for analysis. Results: No significant group differences were detected in HRV indices at BASE, POST1, or POST2 during both trials (p > 0.05). Rate of recovery (POST2–POST1) for the square root of the mean of squared differences between successive RR intervals (RMSSD) was significantly different between A/A (6.0 ± 2.5 ms) and C allele (3.6 ± 2.5 ms) groups during the CAF trial (p = 0.048). Conclusions: Rate of RMSSD recovery was the only variable influenced by the CYP1A2*IF polymorphism during post-exercise in response to caffeine intake. Thus, the CYP1A2*1F polymorphism did not overtly influence the effects of caffeine intake on post-exercise HRV. © 2016, Royal Academy of Medicine in Ireland. | en |
dc.language.iso | en | en |
dc.source | Irish Journal of Medical Science | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976491086&doi=10.1007%2fs11845-016-1478-7&partnerID=40&md5=b8db7ef234e0d4cebb9a17ac3af85ca8 | |
dc.subject | caffeine | en |
dc.subject | cytochrome P450 1A2 | en |
dc.subject | DNA | en |
dc.subject | placebo | en |
dc.subject | caffeine | en |
dc.subject | CYP1A2 protein, human | en |
dc.subject | cytochrome P450 1A2 | en |
dc.subject | adult | en |
dc.subject | allele | en |
dc.subject | Article | en |
dc.subject | exercise | en |
dc.subject | female | en |
dc.subject | food intake | en |
dc.subject | genetic polymorphism | en |
dc.subject | heart rate | en |
dc.subject | heart rate variability | en |
dc.subject | homozygote | en |
dc.subject | human | en |
dc.subject | human experiment | en |
dc.subject | male | en |
dc.subject | normal human | en |
dc.subject | oxygen consumption | en |
dc.subject | RR interval | en |
dc.subject | controlled study | en |
dc.subject | double blind procedure | en |
dc.subject | drug effects | en |
dc.subject | exercise | en |
dc.subject | genetic polymorphism | en |
dc.subject | genetics | en |
dc.subject | heterozygote | en |
dc.subject | middle aged | en |
dc.subject | physiology | en |
dc.subject | randomized controlled trial | en |
dc.subject | young adult | en |
dc.subject | Adult | en |
dc.subject | Alleles | en |
dc.subject | Caffeine | en |
dc.subject | Cytochrome P-450 CYP1A2 | en |
dc.subject | Double-Blind Method | en |
dc.subject | Exercise | en |
dc.subject | Female | en |
dc.subject | Heart Rate | en |
dc.subject | Heterozygote | en |
dc.subject | Homozygote | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Young Adult | en |
dc.subject | Springer London | en |
dc.title | Influence of a CYP1A2 polymorphism on post-exercise heart rate variability in response to caffeine intake: a double-blind, placebo-controlled trial | en |
dc.type | journalArticle | en |