Visualizing High-dimensional single-cell RNA-sequencing data through multiple Random Projections
Date
2019Language
en
Keyword
Abstract
Recent sequencing technology breakthroughs have resulted in a dramatic increase in the amount of available sequencing data, enabling major scientific advances in biology and medicine. Nowadays, sequencing transcriptome data of single cells (scRNA-seq) are growing rapidly, posing new challenges in their analysis, mostly due to their high dimensionality. In this paper, we study the problem of visualizing such high-dimensional scRNA-seq data. A new visualization scheme is presented based on a customized distance matrix retrieved by applying independently Nearest Neighbors search through multiple Random Projections. The proposed method is compared against well-known dimensionality reduction and visualization techniques showing its capabilities and performance. © 2018 IEEE.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Trends in prevalence of blindness and distance and near vision impairment over 30 years: An analysis for the Global Burden of Disease Study
Bourne R.R.A., Steinmetz J.D., Flaxman S., Briant P.S., Taylor H.R., Resnikoff S., Casson R.J., Abdoli A., Abu-Gharbieh E., Afshin A., Ahmadieh H., Akalu Y., Alamneh A.A., Alemayehu W., Alfaar A.S., Alipour V., Anbesu E.W., Androudi S., Arabloo J., Arditi A., Asaad M., Bagli E., Baig A.A., Bärnighausen T.W., Parodi M.B., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A.M., Butt Z.A., Cheng C.-Y., Chu D.-T., Cicinelli M.V., Coelho J.M., Dagnew B., Dai X., Dana R., Dandona L., Dandona R., Del Monte M.A., Deva J.P., Diaz D., Djalalinia S., Dreer L.E., Ehrlich J.R., Ellwein L.B., Emamian M.H., Fernandes A.G., Fischer F., Friedman D.S., Furtado J.M., Gaidhane A.M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B.R., Hartnett M.E.R., Hartono R.K., Hay S.I., Heidari G., Ho H.C., Hoang C.L., Househ M., Ibitoye S.E., Ilic I.M., Ilic M.D., Ingram A.D., Irvani S.S.N., Jha R.P., Kahloun R., Kandel H., Kasa A.S., Kempen J.H., Keramati M., Khairallah M., Khan E.A., Khanna R.C., Khatib M.N., Kim J.E., Kim Y.J., Kisa A., Kisa S., Koyanagi A., Kurmi O.P., Lansingh V.C., Leasher J.L., Leveziel N., Limburg H., Majdan M., Manafi N., Mansouri K., McAlinden C., Mohammadi S.F., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mokdad A.H., Moosavi D., Morse A.R., Naderi M., Naidoo K.S., Nangia V., Nguyen C.T., Nguyen H.L.T., Ogundimu K., Olagunju A.T., Ostroff S.M., Panda-Jones S., Pesudovs K., Peto T., Syed Z.Q., Ur Rahman M.H., Ramulu P.Y., Rawaf D.L., Rawaf S., Reinig N., Robin A.L., Rossetti L., Safi S., Sahebkar A., Samy A.M., Saxena D., Serle J.B., Shaikh M.A., Shen T.T., Shibuya K., Shin J.I., Silva J.C., Silvester A., Singh J.A., Singhal D., Sitorus R.S., Skiadaresi E., Skirbekk V., Soheili A., Sousa R.A.R.C., Spurlock E.E., Stambolian D., Taddele B.W., Tadesse E.G., Tahhan N., Tareque Md.I., Topouzis F., Tran B.X., Travillian R.S., Tsilimbaris M.K., Varma R., Virgili G., Wang N., Wang Y.X., West S.K., Wong T.Y., Zaidi Z., Zewdie K.A., Jonas J.B., Vos T., GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study (2021)Background: To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. We aimed to extensively update estimates of global vision ... -
Case Series: Bilateral Homonymous Visual Field Defects Due to Bilateral Ischemic Strokes
Papageorgiou E., Anthis N., Stathi T., Tsironi E., Asproudis I. (2018)SIGNIFICANCE Bilateral strokes are rare and should be considered when patients present with bilateral visual field loss characterized by patterns consistent with right and left-sided homonymous visual field defects. ... -
Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study
Bourne R.R.A., Steinmetz J.D., Saylan M., Mersha A.M., Weldemariam A.H., Wondmeneh T.G., Sreeramareddy C.T., Pinheiro M., Yaseri M., Yu C., Zastrozhin M.S., Zastrozhina A., Zhang Z.-J., Zimsen S.R.M., Yonemoto N., Tsegaye G.W., Vu G.T., Vongpradith A., Renzaho A.M.N., Sorrie M.B., Shaheen A.A., Shiferaw W.S., Skryabin V.Y., Skryabina A.A., Saya G.K., Rahimi-Movaghar V., Shigematsu M., Sahraian M.A., Naderifar H., Sabour S., Rathi P., Sathian B., Miller T.R., Rezapour A., Rawal L., Pham H.Q., Parekh U., Podder V., Onwujekwe O.E., Pasovic M., Otstavnov N., Negash H., Pawar S., Naimzada M.D., Al Montasir A., Ogbo F.A., Owolabi M.O., Pakshir K., Mohammad Y., Moni M.A., Nunez-Samudio V., Mulaw G.F., Naveed M., Maleki S., Michalek I.M., Misra S., Swamy S.N., Mohammed J.A., Flaxman S., Park E.-C., Briant P.S., Meles G.G., Hayat K., Landires I., Kim G.R., Liu X., LeGrand K.E., Taylor H.R., Kunjathur S.M., Khoja T.A.M., Bicer B.K., Khalilov R., Hashi A., Kayode G.A., Carneiro V.L.A., Kavetskyy T., Kosen S., Kulkarni V., Holla R., Kalhor R., Jayaram S., Islam S.M.S., Gilani S.A., Eskandarieh S., Molla M.D., Itumalla R., Farzadfar F., Congdon N.G., Elhabashy H.R., Elayedath R., Couto R.A.S., Dervenis N., Cromwell E.A., Dahlawi S.M.A., Resnikoff S., Casson R.J., Abdoli A., Choi J.-Y.J., Dos Santos F.L.C., Abrha W.A., Nagaraja S.B., Abualhasan A., Adal T.G., Aregawi B.B., Beheshti M., Abu-Gharbieh E., Afshin A., Ahmadieh H., Alemzadeh S.A., Arrigo A., Atnafu D.D., Ashbaugh C., Ashrafi E., Alemayehu W., Alfaar A.S., Alipour V., Anbesu E.W., Androudi S., Arabloo J., Arditi A., Bagli E., Baig A.A., Bärnighausen T.W., Parodi M.B., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A.M., Butt Z.A., Cheng C.-Y., Chu D.-T., Cicinelli M.V., Coelho J.M., Dai X., Dana R., Dandona L., Dandona R., Del Monte M.A., Deva J.P., Diaz D., Djalalinia S., Dreer L.E., Ehrlich J.R., Ellwein L.B., Emamian M.H., Fernandes A.G., Fischer F., Friedman D.S., Furtado J.M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B.R., Hartnett M.E.R., Hartono R.K., Hay S.I., Heidari G., Ho H.C., Househ M., Ibitoye S.E., Ilic I.M., Huang J.J., Ilic M.D., Ingram A.D., Irvani S.S.N., Jha R.P., Kahloun R., Kandel H., Kasa A.S., Kempen J.H., Khairallah M., Khan E.A., Khanna R.C., Khatib M.N., Kim J.E., Kim Y.J., Kisa A., Kisa S., Koyanagi A., Kurmi O.P., Lansingh V.C., Leasher J.L., Leveziel N., Limburg H., Manafi N., Mansouri K., McAlinden C., Mohammadi S.F., Mokdad A.H., Morse A.R., Naderi M., Naidoo K.S., Nangia V., Nguyen H.L.T., Ogundimu K., Olagunju A.T., Panda-Jonas S., Pesudovs K., Peto T., Ur Rahman M.H., Ramulu P.Y., Rawaf D.L., Rawaf S., Reinig N., Robin A.L., Rossetti L., Safi S., Sahebkar A., Samy A.M., Serle J.B., Shaikh M.A., Shen T.T., Shibuya K., Shin J.I., Silva J.C., Silvester A., Singh J.A., Singhal D., Sitorus R.S., Skiadaresi E., Soheili A., Sousa R.A.R.C., Stambolian D., Tadesse E.G., Tahhan N., Tareque Md.I., Topouzis F., Tran B.X., Tsilimbaris M.K., Varma R., Virgili G., Wang N., Wang Y.X., West S.K., Wong T.Y., Jonas J.B., Vos T., GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study (2021)Background: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of ...