Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis
dc.creator | Siokas V., Aloizou A.-M., Liampas I., Tsouris Z., Mentis A.-F.A., Nasios G., Papadimitriou D., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. | en |
dc.date.accessioned | 2023-01-31T09:56:42Z | |
dc.date.available | 2023-01-31T09:56:42Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.1007/s11033-021-06312-1 | |
dc.identifier.issn | 03014851 | |
dc.identifier.uri | http://hdl.handle.net/11615/79022 | |
dc.description.abstract | Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease. Inflammatory processes are among the mechanisms that are implicated in ALS pathogenesis. The TREM2 rs75932628 T variant may influence the regulatory effect of TREM2 on inflammation. Studies regarding the role of the rs75932628 variant in ALS have yielded inconsistent results, so far. To assess the role of TREM2 rs75932628 on ALS risk. We genotyped 155 patients with sporadic ALS and 155 healthy controls for TREM2 rs75932628. We also merged and meta-analyzed our data with data from previous studies (with a total of 7524 ALS cases and 14,675 controls), regarding TREM2 rs75932628 and ALS. No ALS or healthy subjects carried the TREM2 rs75932628-T variant. Results from meta-analyses (overall approach and sensitivity analyses) yielded no significant results for possible connection between TREM2 rs75932628-T variant and ALS. Based on our results, TREM2 rs75932628 does not seem to play a determining role to the pathophysiology of ALS. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. | en |
dc.language.iso | en | en |
dc.source | Molecular Biology Reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103893173&doi=10.1007%2fs11033-021-06312-1&partnerID=40&md5=138c1865fa53587cb805d7f2d45d6a5b | |
dc.subject | triggering receptor expressed on myeloid cells 2 | en |
dc.subject | immunoglobulin receptor | en |
dc.subject | membrane protein | en |
dc.subject | TREM2 protein, human | en |
dc.subject | adult | en |
dc.subject | amyotrophic lateral sclerosis | en |
dc.subject | Article | en |
dc.subject | clinical evaluation | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | genetic association | en |
dc.subject | genetic trait | en |
dc.subject | genetic variability | en |
dc.subject | genotype | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | risk assessment | en |
dc.subject | sensitivity analysis | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | TREM2 gene | en |
dc.subject | amyotrophic lateral sclerosis | en |
dc.subject | cohort analysis | en |
dc.subject | genetic association study | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | meta analysis (topic) | en |
dc.subject | middle aged | en |
dc.subject | publishing | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | Amyotrophic Lateral Sclerosis | en |
dc.subject | Cohort Studies | en |
dc.subject | Female | en |
dc.subject | Genetic Association Studies | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Membrane Glycoproteins | en |
dc.subject | Meta-Analysis as Topic | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Publication Bias | en |
dc.subject | Receptors, Immunologic | en |
dc.subject | Springer Science and Business Media B.V. | en |
dc.title | Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis | en |
dc.type | journalArticle | en |
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