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BAFF receptor polymorphisms and deficiency in humans
dc.creator | Sevdali E., Block Saldana V., Speletas M., Eibel H. | en |
dc.date.accessioned | 2023-01-31T09:55:12Z | |
dc.date.available | 2023-01-31T09:55:12Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.1016/j.coi.2021.06.008 | |
dc.identifier.issn | 09527915 | |
dc.identifier.uri | http://hdl.handle.net/11615/78904 | |
dc.description.abstract | The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including survival, protein synthesis, and metabolic fitness. In humans, BAFFR deficiency interrupts B cell development at the transition from immature to mature B cells and causes B lymphopenia, hypogammaglobulinemia, and impaired humoral immune responses. Polymorphisms in TNFRSF13C gene affecting BAFFR oligomerization and signaling have been described in patients with immunodeficiency, autoimmunity and B cell lymphomas. Despite a uniform expression pattern of BAFFR in peripheral mature B cells, depletion of BAFF with neutralizing antibodies in patients with systemic lupus erythematosus does not affect the survival of switched memory B cells. These findings imply a distinct dependency of mature B cell subsets on BAFF/BAFFR interaction and highlight the contribution of BAFFR-derived signals in peripheral B cell development and homeostasis. © 2021 Elsevier Ltd | en |
dc.language.iso | en | en |
dc.source | Current Opinion in Immunology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109392037&doi=10.1016%2fj.coi.2021.06.008&partnerID=40&md5=8590b26be5cfbf45c49451520e7085d4 | |
dc.subject | a disintegrin and metalloproteinase domain-containing protein 10 | en |
dc.subject | B cell activating factor receptor | en |
dc.subject | CD19 antigen | en |
dc.subject | CD40 ligand | en |
dc.subject | furin | en |
dc.subject | immunoglobulin | en |
dc.subject | immunoglobulin G | en |
dc.subject | immunoglobulin M | en |
dc.subject | phosphatidylinositol 3 kinase | en |
dc.subject | protein | en |
dc.subject | tumor necrosis factor | en |
dc.subject | unclassified drug | en |
dc.subject | B cell activating factor | en |
dc.subject | B cell activating factor receptor | en |
dc.subject | TNFRSF13C protein, human | en |
dc.subject | TNFSF13B protein, human | en |
dc.subject | amino acid substitution | en |
dc.subject | antigen presenting cell | en |
dc.subject | apoptosis | en |
dc.subject | autoimmunity | en |
dc.subject | B cell lymphoma | en |
dc.subject | cancer survival | en |
dc.subject | CD8+ T lymphocyte | en |
dc.subject | DNA polymorphism | en |
dc.subject | gene deletion | en |
dc.subject | gene expression | en |
dc.subject | gene frequency | en |
dc.subject | genetic polymorphism | en |
dc.subject | genetic variability | en |
dc.subject | human | en |
dc.subject | humoral immunity | en |
dc.subject | immune system | en |
dc.subject | immunoglobulin deficiency | en |
dc.subject | lymphocytopenia | en |
dc.subject | multiple sclerosis | en |
dc.subject | protein expression | en |
dc.subject | Review | en |
dc.subject | signal transduction | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | systemic lupus erythematosus | en |
dc.subject | whole exome sequencing | en |
dc.subject | B lymphocyte | en |
dc.subject | genetics | en |
dc.subject | homeostasis | en |
dc.subject | immunology | en |
dc.subject | B-Cell Activating Factor | en |
dc.subject | B-Cell Activation Factor Receptor | en |
dc.subject | B-Lymphocytes | en |
dc.subject | Homeostasis | en |
dc.subject | Humans | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Elsevier Ltd | en |
dc.title | BAFF receptor polymorphisms and deficiency in humans | en |
dc.type | other | en |
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