Atrial Cardiopathy and Likely Pathogenic Patent Foramen Ovale in Embolic Stroke of Undetermined Source
Ημερομηνία
2021Γλώσσα
en
Λέξη-κλειδί
Επιτομή
Background Atrial cardiopathy and likely pathogenic patent foramen ovale (PFO) are two potential embolic sources in patients with embolic stroke of undetermined source (ESUS). The relationship between these two mechanisms among ESUS patients remains unclear. Methods Atrial cardiopathy was defined as increased left atrial diameter index (> 23 mm/m 2) or left atrial volume index (> 34 mL/m 2), or PR prolongation (≥ 200 ms), or presence of supraventricular extrasystoles in the electrocardiograms performed during hospitalization for the index stoke. The presence of PFO was assessed by transthoracic echocardiography with microbubble test or by transesophageal echocardiography. The presence of PFO was considered as likely pathogenic if the Risk of Paradoxical Embolism score was 7 to 10. Results Among 367 ESUS patients with available information about the presence of PFO and the presence of atrial cardiopathy (median age: 61 years, 40.6% women), likely pathogenic PFO was diagnosed in 62 (16.9%) and atrial cardiopathy in 122 (33.2%). Only 4 patients (1.1%) had both likely pathogenic PFO and atrial cardiopathy. The prevalence of atrial cardiopathy was lower in patients with likely pathogenic PFO (6.5%) compared with patients with likely incidental PFO (31.2%) or without PFO (40.6%) (Pearson's chi-square test: 26.08, p < 0.001; adjusted odds ratio [OR]: 0.28, 95% confidence interval [CI]: 0.09-0.86). The prevalence of likely pathogenic PFO was lower in patients with atrial cardiopathy compared with patients without atrial cardiopathy (3.3% vs. 23.7%, respectively [Pearson's chi-square test: 24.13, p < 0.001; adjusted OR: 0.2, 95% CI: 0.02-0.6]). Conclusion The presence of atrial cardiopathy is inversely related to the presence of likely pathogenic PFO in patients with ESUS. © 2020. Thieme. All rights reserved.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Risk in atrial fibrillation: left atrial function matters
Triposkiadis F., Xanthopoulos A., Parissis J. (2019)[No abstract available] -
Left ventricular hypertrophy and sudden cardiac death
Giamouzis G., Dimos A., Xanthopoulos A., Skoularigis J., Triposkiadis F. (2022)Sudden cardiac death (SCD) is among the leading causes of death worldwide, and it remains a public health problem, as it involves young subjects. Current guideline-directed risk stratification for primary prevention is ... -
Thrombolysis for massive pulmonary embolism in a patient with hemorrhagic shock
Papanikolaou J., Spathoulas K., Makris D., Zakynthinos E. (2016)[No abstract available]