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Resveratrol, curcumin and gallic acid attenuate glyoxal-induced damage to rat renal cells

dc.creatorHashemzaei M., Tabrizian K., Alizadeh Z., Pasandideh S., Rezaee R., Mamoulakis C., Tsatsakis A., Skaperda Z., Kouretas D., Shahraki J.en
dc.date.accessioned2023-01-31T08:27:59Z
dc.date.available2023-01-31T08:27:59Z
dc.date.issued2020
dc.identifier10.1016/j.toxrep.2020.11.008
dc.identifier.issn22147500
dc.identifier.urihttp://hdl.handle.net/11615/73925
dc.description.abstractGlyoxal (GO), a by-product of glucose auto-oxidation, is involved in the glycation of proteins/ lipids and formation of advanced glycation (AGE) and lipoxidation (ALE) end products. AGE/ALE were shown to contribute to diabetic complications development/progression such as nephropathy. Diabetic nephropathy progression has an oxidative nature. Given the antioxidant effects of polyphenols, potential protective effects of resveratrol, curcumin and gallic acid, in rat renal cells treated with GO, were evaluated in the present work. According to our results, incubation of GO with the cells reduced their viability and led to membrane lysis, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial membrane potential collapse, and lysosomal membrane leakage. These findings were prevented by pre-treatment with resveratrol, curcumin and gallic acid. Mitochondrial and lysosomal toxic interactions appear to worsen oxidative stress/cytotoxicity produced by GO. Resveratrol, curcumin and gallic acid inhibited ROS formation and attenuated GO-induced renal cell death. © 2020 The Author(s)en
dc.language.isoenen
dc.sourceToxicology Reportsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85097390099&doi=10.1016%2fj.toxrep.2020.11.008&partnerID=40&md5=9f919696c079858b97e6e18bd7758d83
dc.subjectchloroquineen
dc.subjectcurcuminen
dc.subjectdimethyl sulfoxideen
dc.subjectgallic aciden
dc.subjectglutamineen
dc.subjectglyoxalen
dc.subjectmannitolen
dc.subjectreactive oxygen metaboliteen
dc.subjectresveratrolen
dc.subjectthiobarbituric acid reactive substanceen
dc.subjectanimal cellen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectantioxidant activityen
dc.subjectapoptosisen
dc.subjectArticleen
dc.subjectcell viabilityen
dc.subjectcontrolled studyen
dc.subjectcytotoxicityen
dc.subjectdiabetes mellitusen
dc.subjectdiabetic nephropathyen
dc.subjectEC50en
dc.subjectkidney injuryen
dc.subjectlipid peroxidationen
dc.subjectlipid peroxidation assayen
dc.subjectlysosome membraneen
dc.subjectmaleen
dc.subjectmitochondrial membrane potentialen
dc.subjectmitochondrial permeabilityen
dc.subjectnonhumanen
dc.subjectoxidative stressen
dc.subjectraten
dc.subjectspectrofluorometryen
dc.subjecttrypan blue assayen
dc.subjectElsevier Inc.en
dc.titleResveratrol, curcumin and gallic acid attenuate glyoxal-induced damage to rat renal cellsen
dc.typejournalArticleen


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