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A case-control study on the risk factors for meningococcal disease among children in Greece

dc.creatorHadjichristodoulou C., Mpalaouras G., Vasilopoulou V., Katsioulis A., Rachiotis G., Theodoridou K., Tzanakaki G., Syriopoulou V., Theodoridou M.en
dc.date.accessioned2023-01-31T08:27:24Z
dc.date.available2023-01-31T08:27:24Z
dc.date.issued2016
dc.identifier10.1371/journal.pone.0158524
dc.identifier.issn19326203
dc.identifier.urihttp://hdl.handle.net/11615/73750
dc.description.abstractPurpose: The aim of this study was to identify environmental or genetic risk factors that are associated with invasive meningococcal disease (IMD) in children in Greece. Methods: A case-control study was performed in 133 children (44 cases and 89 controls) aged between 0-14 years, who were hospitalized in a children's hospital in Athens. Demographics and possible risk factors were collected by the use of a structured questionnaire. To investigate the association of mannose binding lectin (MBL) with IMD, a frequency analysis of the haplotypes of the MBL2 gene and quantitative measurement of MBL serum protein levels were performed using Nanogen NanoChipR 400 technology and immuno-enzyme techniques, respectively. Results: The multivariate analysis revealed that changes in a child's life setting (relocation or vacation, OR = 7.16), paternal smoking (OR = 4.51), upper respiratory tract infection within the previous month (OR = 3.04) and the density of people in the house/100m2 (OR = 3.16), were independent risk factors associated with IMD. Overall 18.8%of patients had a MBL2 genotype with low functionality compared to 10.1% of healthy controls, but this was not statistically significant (p = 0.189). Conclusion: Prevention strategies aimed at reducing parental smoking and other risk factors identified in this study could decrease the risk of IMD among children in Greece. © 2016 Hadjichristodoulou et al.en
dc.language.isoenen
dc.sourcePLoS ONEen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84978162009&doi=10.1371%2fjournal.pone.0158524&partnerID=40&md5=f5b271a4c892ef9a98a2d8a02523d4ff
dc.subjectmannose binding lectinen
dc.subjectmannose binding lectin 2en
dc.subjectmannose binding lectinen
dc.subjectMBL2 protein, humanen
dc.subjectpassive smokingen
dc.subjectadolescenten
dc.subjectArticleen
dc.subjectcase control studyen
dc.subjectchilden
dc.subjectchild hospitalizationen
dc.subjectcontrolled studyen
dc.subjectdemographyen
dc.subjectenvironmental factoren
dc.subjectenzyme immunoassayen
dc.subjectfemaleen
dc.subjectgenetic analysisen
dc.subjectgenetic risken
dc.subjectgenotypeen
dc.subjectGreeceen
dc.subjecthaplotypeen
dc.subjecthumanen
dc.subjectinfanten
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectMBL2 geneen
dc.subjectmeningococcosisen
dc.subjectmultivariate analysisen
dc.subjectnewbornen
dc.subjectpaternal smokingen
dc.subjectpediatric hospitalen
dc.subjectprotein blood levelen
dc.subjectquestionnaireen
dc.subjectrisk factoren
dc.subjectstructured questionnaireen
dc.subjectupper respiratory tract infectionen
dc.subjectblooden
dc.subjectgeneticsen
dc.subjectMeningococcal Infectionsen
dc.subjectpassive smokingen
dc.subjectpreschool childen
dc.subjectRespiratory Tract Infectionsen
dc.subjectAdolescenten
dc.subjectCase-Control Studiesen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectGreeceen
dc.subjectHaplotypesen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectMaleen
dc.subjectMannose-Binding Lectinen
dc.subjectMeningococcal Infectionsen
dc.subjectRespiratory Tract Infectionsen
dc.subjectTobacco Smoke Pollutionen
dc.subjectPublic Library of Scienceen
dc.titleA case-control study on the risk factors for meningococcal disease among children in Greeceen
dc.typejournalArticleen


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