dc.creator | CHRISTODOULIDIS G., SAMARA A.A., FLOROS T., KARAKANTAS K.-S., ZOTOS P.-A., KOUTRAS A., TEPETES K. | en |
dc.date.accessioned | 2023-01-31T07:46:11Z | |
dc.date.available | 2023-01-31T07:46:11Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.21873/INVIVO.12553 | |
dc.identifier.issn | 0258851X | |
dc.identifier.uri | http://hdl.handle.net/11615/72844 | |
dc.description.abstract | Background/Aim: We aimed to evaluate the safety and efficacy of sealing primary upper gastrointestinal (GI) perforations with a collagen patch coated with fibrin glue (Tachosil®). Materials and Methods: Thirty New Zealand rabbits were used in this study. An iatrogenic gastric perforation was created, and primary repair was performed on the control group. Tachosil®, without suturing the deficit, was used in the intervention group. Results: Leakage was observed in 3 (20%) and 2 rabbits (13.3%) in the control and intervention group, respectively; however, the difference was not statistically significant (p=0.62). Moreover, adhesions formed in 10/15 and all rabbits in the intervention and control group, respectively (p=0.014); however, based on the Zuhlke adhesion's classification, there was no statistically significant difference between the two groups. Conclusion: A collagen patch coated with fibrin glue is not a replacement but can be considered a safe option for the reinforcement of suturing, preventing leakages in the upper GI tract. © 2021 International Institute of Anticancer Research. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | In Vivo | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113899869&doi=10.21873%2fINVIVO.12553&partnerID=40&md5=71a56b2e36ad8ff0dba82f4d6979ba49 | |
dc.subject | collagen | en |
dc.subject | fibrin glue | en |
dc.subject | fibrinogen plus thrombin | en |
dc.subject | ketamine | en |
dc.subject | midazolam | en |
dc.subject | collagen | en |
dc.subject | adhesion | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | animal tissue | en |
dc.subject | Article | en |
dc.subject | controlled study | en |
dc.subject | experimental study | en |
dc.subject | female | en |
dc.subject | mortality | en |
dc.subject | New Zealand rabbit | en |
dc.subject | nonhuman | en |
dc.subject | risk assessment | en |
dc.subject | stomach perforation | en |
dc.subject | upper gastrointestinal tract | en |
dc.subject | animal | en |
dc.subject | Leporidae | en |
dc.subject | tissue adhesion | en |
dc.subject | upper gastrointestinal tract | en |
dc.subject | Animals | en |
dc.subject | Collagen | en |
dc.subject | Fibrin Tissue Adhesive | en |
dc.subject | Rabbits | en |
dc.subject | Tissue Adhesions | en |
dc.subject | Upper Gastrointestinal Tract | en |
dc.subject | International Institute of Anticancer Research | en |
dc.title | The contribution of a collagen patch coated with fibrin glue in sealing upper gastrointestinal defects: An experimental study | en |
dc.type | journalArticle | en |