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A Critical Appraisal of the Effects of Anesthetics on Immune-system Modulation in Critically Ill Patients With COVID-19

dc.creatorChalkias A., Barreto E.F., Laou E., Kolonia K., Scheetz M.H., Gourgoulianis K., Pantazopoulos I., Xanthos T.en
dc.date.accessioned2023-01-31T07:42:30Z
dc.date.available2023-01-31T07:42:30Z
dc.date.issued2021
dc.identifier10.1016/j.clinthera.2021.01.004
dc.identifier.issn01492918
dc.identifier.urihttp://hdl.handle.net/11615/72421
dc.description.abstractPurpose: The aim of the present article was to briefly summarize current knowledge about the immunomodulatory effects of general anesthetics and the possible clinical effects of this immunomodulation in patients with COVID-19. Methods: The PubMed, Scopus, and Google Scholar databases were comprehensively searched for relevant studies. Findings: The novel coronavirus causes a wide spectrum of clinical manifestations, with a large absolute number of patients experiencing severe pneumonia and rapid progression to acute respiratory distress syndrome and multiple organ failure. In these patients, the equilibrium of the inflammatory response is a major determinant of survival. The impact of anesthetics on immune-system modulation may vary and includes both pro-inflammatory and anti-inflammatory effects. Implications: Inhibition of the development of severe inflammation and/or the enhancement of inflammation resolution by anesthetics may limit organ damage and improve outcomes in patients with COVID-19. © 2021 Elsevier Inc.en
dc.language.isoenen
dc.sourceClinical Therapeuticsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85100437456&doi=10.1016%2fj.clinthera.2021.01.004&partnerID=40&md5=562200dd616c3d2a8dee6f055ec5d877
dc.subjectanesthetic agenten
dc.subjectcisatracuriumen
dc.subjectcytochrome P450en
dc.subjectdexmedetomidineen
dc.subjectetomidateen
dc.subjectfentanylen
dc.subjectmidazolamen
dc.subjectopiateen
dc.subjectpropofolen
dc.subjectrocuroniumen
dc.subjectsufentanilen
dc.subjectsuxamethoniumen
dc.subjectanesthetic agenten
dc.subjectadaptive immunityen
dc.subjectadulten
dc.subjectadult respiratory distress syndromeen
dc.subjectarachidonic acid metabolismen
dc.subjectcontrolled studyen
dc.subjectcoronavirus disease 2019en
dc.subjectcritically ill patienten
dc.subjectdisease exacerbationen
dc.subjectendotracheal intubationen
dc.subjectfemaleen
dc.subjecthistiocyteen
dc.subjecthumanen
dc.subjectimmune systemen
dc.subjectimmunomodulationen
dc.subjectinnate immunityen
dc.subjectmaleen
dc.subjectMedlineen
dc.subjectmeta analysisen
dc.subjectmultiple organ failureen
dc.subjectnoninvasive ventilationen
dc.subjectReviewen
dc.subjectScopusen
dc.subjectsearch engineen
dc.subjectsystematic reviewen
dc.subjectcomplicationen
dc.subjectcritical illnessen
dc.subjectdrug effecten
dc.subjectimmune systemen
dc.subjectimmunologyen
dc.subjectinflammationen
dc.subjectpneumoniaen
dc.subjectrespiratory distress syndromeen
dc.subjectvirologyen
dc.subjectAnestheticsen
dc.subjectCOVID-19en
dc.subjectCritical Illnessen
dc.subjectHumansen
dc.subjectImmune Systemen
dc.subjectInflammationen
dc.subjectPneumoniaen
dc.subjectRespiratory Distress Syndromeen
dc.subjectExcerpta Medica Inc.en
dc.titleA Critical Appraisal of the Effects of Anesthetics on Immune-system Modulation in Critically Ill Patients With COVID-19en
dc.typeotheren


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