dc.creator | Ceccarelli F., Perricone C., Cipriano E., Massaro L., Natalucci F., Capalbo G., Leccese I., Bogdanos D., Spinelli F.R., Alessandri C., Valesini G., Conti F. | en |
dc.date.accessioned | 2023-01-31T07:41:57Z | |
dc.date.available | 2023-01-31T07:41:57Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1016/j.semarthrit.2017.03.022 | |
dc.identifier.issn | 00490172 | |
dc.identifier.uri | http://hdl.handle.net/11615/72329 | |
dc.description.abstract | Objective In the present review, the different phenotypes, clinimetric and imaging tools able to assess joint involvement in patients affected by Systemic Lupus Erythematosus (SLE) have been described and summarized. Furthermore, the current knowledge about the pathogenic mechanism and the potential biomarkers of this feature is reported. Methods A literature search was done in PubMed, accessed via the National Library of Medicine PubMed interface (http://www.ncbi.nlm.nih.gov/pubmed). Firstly, PubMed was searched using the term “systemic lupus erythematosus” OR “lupus” in combination with (AND) “joint” OR “articular”.Secondly, the same PubMed research was combined with other terms, such as “pathogenesis” OR “genetic” OR “antibodies” OR “biomarkers” OR “cytokines” OR “imaging” OR “ultrasonography” OR “magnetic resonance” OR “clinimetry”. Results After a stringent selection, we evaluated in the present review 13 papers concerning clinical phenotypes of SLE joint involvement, 14 concerning clinimetric assessment, 20 concerning imaging, and finally, 28 concerning pathogenesis and biomarkers. Further relevant data were obtained from the reference lists of articles returned using these search terms and from authors own experience and knowledge of the literature. Conclusion Despite the prevalence and severity of SLE joint involvement, more awareness and a deeper evaluation of the clinical heterogeneity of this manifestation are mandatory. Moreover, longitudinal studies are needed to assess the progression of this manifestation and to provide standard definitions and examination/recording protocols. © 2017 Elsevier Inc. | en |
dc.language.iso | en | en |
dc.source | Seminars in Arthritis and Rheumatism | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018426278&doi=10.1016%2fj.semarthrit.2017.03.022&partnerID=40&md5=4d3981a91778ab971ed3d314588e13a9 | |
dc.subject | biological marker | en |
dc.subject | C reactive protein | en |
dc.subject | interferon regulatory factor 5 | en |
dc.subject | interleukin 1 receptor associated kinase 1 | en |
dc.subject | STAT1 protein | en |
dc.subject | tumor necrosis factor receptor associated factor 6 | en |
dc.subject | abatacept | en |
dc.subject | antirheumatic agent | en |
dc.subject | biological marker | en |
dc.subject | bone erosion | en |
dc.subject | clinical feature | en |
dc.subject | DAS28 | en |
dc.subject | disease classification | en |
dc.subject | disease course | en |
dc.subject | erythrocyte sedimentation rate | en |
dc.subject | functional assessment | en |
dc.subject | human | en |
dc.subject | joint limitation | en |
dc.subject | joint radiography | en |
dc.subject | meta analysis | en |
dc.subject | musculoskeletal disease assessment | en |
dc.subject | nuclear magnetic resonance imaging | en |
dc.subject | priority journal | en |
dc.subject | Review | en |
dc.subject | rheumatoid arthritis | en |
dc.subject | symptomatology | en |
dc.subject | systematic review | en |
dc.subject | systemic lupus erythematosus | en |
dc.subject | ultrasound | en |
dc.subject | arthritis | en |
dc.subject | complication | en |
dc.subject | diagnostic imaging | en |
dc.subject | disease exacerbation | en |
dc.subject | joint | en |
dc.subject | pathology | en |
dc.subject | pathophysiology | en |
dc.subject | severity of illness index | en |
dc.subject | systemic lupus erythematosus | en |
dc.subject | Abatacept | en |
dc.subject | Antirheumatic Agents | en |
dc.subject | Arthritis | en |
dc.subject | Biomarkers | en |
dc.subject | Disease Progression | en |
dc.subject | Humans | en |
dc.subject | Joints | en |
dc.subject | Lupus Erythematosus, Systemic | en |
dc.subject | Severity of Illness Index | en |
dc.subject | W.B. Saunders | en |
dc.title | Joint involvement in systemic lupus erythematosus: From pathogenesis to clinical assessment | en |
dc.type | other | en |