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Interactome of obesity: Obesidome: Genetic obesity, stress induced obesity, pathogenic obesity interaction

dc.creatorGeronikolou S.A., Pavlopoulou A., Cokkinos D., Chrousos G.en
dc.date.accessioned2023-01-31T07:41:26Z
dc.date.available2023-01-31T07:41:26Z
dc.date.issued2017
dc.identifier10.1007/978-3-319-57379-3_21
dc.identifier.issn00652598
dc.identifier.urihttp://hdl.handle.net/11615/72248
dc.description.abstractObesity is a chronic disease of increasing prevalence reaching epidemic proportions. Genetic defects as well as epigenetic effects contribute to the obesity phenotype. Investigating gene (e.g. MC4R defects)-environment (behavior, infectious agents, stress) interactions is a relative new field of great research interest. In this study, we have made an effort to create an interactome (henceforth referred to as “obesidome”), where extrinsic stressors response, intrinsic predisposition, immunity response to inflammation and autonomous nervous system implications are integrated. These pathways are presented in one interactome network for the first time. In our study, obesity-related genes/gene products were found to form a complex interactions network. © Springer International Publishing AG 2017.en
dc.language.isoenen
dc.sourceAdvances in Experimental Medicine and Biologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85030665430&doi=10.1007%2f978-3-319-57379-3_21&partnerID=40&md5=814d737660cda759a204d60cdb836849
dc.subjectagouti related proteinen
dc.subjectamine oxidase (flavin containing) isoenzyme Aen
dc.subjectangiotensinogenen
dc.subjectargipressinen
dc.subjectcatechol methyltransferaseen
dc.subjectcholecystokininen
dc.subjectcholinesteraseen
dc.subjectcocaine and amphetamine regulated transcript peptideen
dc.subjectcorticotropin releasing factoren
dc.subjectdipeptidyl carboxypeptidaseen
dc.subjectgamma interferonen
dc.subjectghrelinen
dc.subjectghrelin receptoren
dc.subjectglucagonen
dc.subjecthistamine methyltransferaseen
dc.subjectinsulinen
dc.subjectintercellular adhesion molecule 1en
dc.subjectinterleukin 6en
dc.subjectinterleukin 6 receptoren
dc.subjectJanus kinase 2en
dc.subjectleptinen
dc.subjectleptin receptoren
dc.subjectmelanocortin 1 receptoren
dc.subjectmelanocortin 2 receptoren
dc.subjectmelanocortin 3 receptoren
dc.subjectmelanocortin 4 receptoren
dc.subjectmelanocortin 5 receptoren
dc.subjectprotein fosen
dc.subjectsomatomedin Cen
dc.subjectunindexed drugen
dc.subjectACE geneen
dc.subjectACE2 geneen
dc.subjectADRB2 geneen
dc.subjectADRB3 geneen
dc.subjectAGRP geneen
dc.subjectAGT geneen
dc.subjectAVP geneen
dc.subjectBCHE geneen
dc.subjectCARTPT geneen
dc.subjectCCK geneen
dc.subjectCHRNA7 geneen
dc.subjectCOMT geneen
dc.subjectCREB1 geneen
dc.subjectCRH geneen
dc.subjectFOS geneen
dc.subjectFTO geneen
dc.subjectGCG geneen
dc.subjectgeneen
dc.subjectgene expressionen
dc.subjectgene interactionen
dc.subjectgene producten
dc.subjectgenetic associationen
dc.subjectgenetic obesityen
dc.subjectGHRL geneen
dc.subjectGHSR geneen
dc.subjectGIPR geneen
dc.subjectHNMT geneen
dc.subjectHTR2A geneen
dc.subjecthumanen
dc.subjectICAM1 geneen
dc.subjectIFNG geneen
dc.subjectIGF1 geneen
dc.subjectIL6 geneen
dc.subjectIL6R geneen
dc.subjectINS geneen
dc.subjectINSIG2 geneen
dc.subjectJAK2 geneen
dc.subjectLEP geneen
dc.subjectLEPR geneen
dc.subjectMAOA geneen
dc.subjectMC1R geneen
dc.subjectMC2R geneen
dc.subjectMC3R geneen
dc.subjectMC4R geneen
dc.subjectMC5R geneen
dc.subjectmolecular biologyen
dc.subjectNMU geneen
dc.subjectNPS geneen
dc.subjectNPY geneen
dc.subjectNR4A1 geneen
dc.subjectobesidomeen
dc.subjectobesityen
dc.subjectpathogenic obesity interactionen
dc.subjectPCK1 geneen
dc.subjectPCSK1 geneen
dc.subjectPDYN geneen
dc.subjectPLIN geneen
dc.subjectPOMC geneen
dc.subjectPPARG geneen
dc.subjectpriority journalen
dc.subjectREN geneen
dc.subjectsingle nucleotide polymorphismen
dc.subjectSTAT3 geneen
dc.subjectstress induced obesityen
dc.subjectTNF geneen
dc.subjectUCP1 geneen
dc.subjectUCP2 geneen
dc.subjectUCP3 geneen
dc.subjectautonomic nervous systemen
dc.subjectgene regulatory networken
dc.subjectgenetic predispositionen
dc.subjectgeneticsen
dc.subjectinflammationen
dc.subjectmental stressen
dc.subjectmetabolismen
dc.subjectobesityen
dc.subjectpathophysiologyen
dc.subjectphysiological stressen
dc.subjectprotein protein interactionen
dc.subjectAutonomic Nervous Systemen
dc.subjectGene Expressionen
dc.subjectGene Regulatory Networksen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHumansen
dc.subjectInflammationen
dc.subjectObesityen
dc.subjectProtein Interaction Mapsen
dc.subjectStress, Physiologicalen
dc.subjectStress, Psychologicalen
dc.subjectSpringer New York LLCen
dc.titleInteractome of obesity: Obesidome: Genetic obesity, stress induced obesity, pathogenic obesity interactionen
dc.typebookChapteren


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