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Clozapine associated with autoimmune reaction, fever and low level cardiotoxicity - a case report
dc.creator | Gerasimou C., Vitali G.P., Vavougios G.D., Papageorgiou C., Douzenis A., Kokoris S.I., Liappas I., Rizos E. | en |
dc.date.accessioned | 2023-01-31T07:41:03Z | |
dc.date.available | 2023-01-31T07:41:03Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.21873/invivo.11037 | |
dc.identifier.issn | 0258851X | |
dc.identifier.uri | http://hdl.handle.net/11615/72196 | |
dc.description.abstract | Background: Clozapine is a second-generation antipsychotic drug used in treatment-resistant schizophrenia. Fever induced by clozapine is a rather frequent side-effect which usually occurs in the first 4 weeks of treatment. Despite its effectiveness, there are potentially life-Threatening adverse effects, such as cardiotoxicity. Case Report: We present the case of a 31-year-old caucasian male with refractory schizophrenia who developed benign fever, increase of C-reactive protein and high troponin levels, without presenting any other signs to myocarditis, on the 13th day under clozapine treatment, which declined progressively upon discontinuation of the drug. Discussion: This case hints at the presence of initially subclinical cardiotoxicity as an underlying factor in patients developing fever. Conclusion: Taking advantage of more sensitive methods for measuring troponin, clinicians would be promptly aware of this possible side-effect. This would allow for significant reduction of the risk of cardiac dysfunction, further attained by carefully monitoring the patient. | en |
dc.language.iso | en | en |
dc.source | In Vivo | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015900043&doi=10.21873%2finvivo.11037&partnerID=40&md5=784e29a8605719fe413458d883ab5c09 | |
dc.subject | C reactive protein | en |
dc.subject | clozapine | en |
dc.subject | creatine kinase MB | en |
dc.subject | lorazepam | en |
dc.subject | paracetamol | en |
dc.subject | procalcitonin | en |
dc.subject | troponin | en |
dc.subject | clozapine | en |
dc.subject | neuroleptic agent | en |
dc.subject | adult | en |
dc.subject | agitation | en |
dc.subject | Article | en |
dc.subject | auditory hallucination | en |
dc.subject | autoimmune disease | en |
dc.subject | cardiotoxicity | en |
dc.subject | case report | en |
dc.subject | delusional disorder | en |
dc.subject | drug dose increase | en |
dc.subject | drug dose titration | en |
dc.subject | drug withdrawal | en |
dc.subject | electrocardiography | en |
dc.subject | fever | en |
dc.subject | gene expression | en |
dc.subject | human | en |
dc.subject | leukocyte count | en |
dc.subject | leukocytosis | en |
dc.subject | male | en |
dc.subject | Mini Mental State Examination | en |
dc.subject | myocarditis | en |
dc.subject | neutrophil | en |
dc.subject | rigor | en |
dc.subject | schizophrenia | en |
dc.subject | sinus tachycardia | en |
dc.subject | sweating | en |
dc.subject | tachycardia | en |
dc.subject | thorax radiography | en |
dc.subject | urinalysis | en |
dc.subject | autoimmunity | en |
dc.subject | cardiotoxicity | en |
dc.subject | chemically induced | en |
dc.subject | drug effects | en |
dc.subject | fever | en |
dc.subject | Adult | en |
dc.subject | Antipsychotic Agents | en |
dc.subject | Autoimmunity | en |
dc.subject | Cardiotoxicity | en |
dc.subject | Clozapine | en |
dc.subject | Electrocardiography | en |
dc.subject | Fever | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Schizophrenia | en |
dc.subject | International Institute of Anticancer Research | en |
dc.title | Clozapine associated with autoimmune reaction, fever and low level cardiotoxicity - a case report | en |
dc.type | journalArticle | en |
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