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Adverse effects of androgen deprivation therapy in patients with prostate cancer: Focus on muscle and bone health

dc.creatorBargiota A., Oeconomou A., Zachos I., Samarinas M., Pisters L.L., Tzortzis V.en
dc.date.accessioned2023-01-31T07:36:06Z
dc.date.available2023-01-31T07:36:06Z
dc.date.issued2020
dc.identifier.issn11070625
dc.identifier.urihttp://hdl.handle.net/11615/71132
dc.description.abstractAndrogen deprivation therapy (ADT) is the most effective systemic treatment for prostate cancer and can be succeeded either surgically or pharmaceutically. Both approaches lead to hypogonadism with a large variety of adverse events, including obesity, metabolic syndrome, osteoporosis, sarcopenia, diabetes mellitus, cardiovascular disease, gynecomastia and sexual dysfunction. In addition, undesirable effects on muscle and bone health may have a significant impact not only on the quality of life but also on life expectancy. Currently, supervised exercise seems to be the only intervention that could prevent the adverse effects of the ADT and improve quality of life. Lifestyle modification, supplementation of calcium, vitamin D and when indicated antiosteoporotic treatments improve bone health. However, patients receiving ADT must be well informed about the potential benefits as well as the risks of the treatment. © 2020 Zerbinis Publications. All rights reserved.en
dc.language.isoenen
dc.sourceJournal of B.U.ON.en
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85090102160&partnerID=40&md5=7130d6493b979ed66ba1445f3d662ecd
dc.subjectabirateroneen
dc.subjectapalutamideen
dc.subjectcalciumen
dc.subjectenzalutamideen
dc.subjectvitamin Den
dc.subjectandrogenen
dc.subjectantineoplastic hormone agonists and antagonistsen
dc.subjectadvanced canceren
dc.subjectadverse eventen
dc.subjectandrogen deprivation therapyen
dc.subjectantiosteoporotic activityen
dc.subjectbone densityen
dc.subjectcancer surgeryen
dc.subjectcardiovascular diseaseen
dc.subjectdiabetes mellitusen
dc.subjectdrug mechanismen
dc.subjectgynecomastiaen
dc.subjecthumanen
dc.subjecthypogonadismen
dc.subjectlife expectancyen
dc.subjectlifestyle modificationen
dc.subjectmaleen
dc.subjectmetabolic syndrome Xen
dc.subjectmuscle massen
dc.subjectmuscle strengthen
dc.subjectobesityen
dc.subjectosteoporosisen
dc.subjectprostate canceren
dc.subjectquality of lifeen
dc.subjectReviewen
dc.subjectsarcopeniaen
dc.subjectsexual dysfunctionen
dc.subjectvitamin supplementationen
dc.subjectboneen
dc.subjectdrug effecten
dc.subjectmuscleen
dc.subjectprostate tumoren
dc.subjectAndrogensen
dc.subjectAntineoplastic Agents, Hormonalen
dc.subjectBone and Bonesen
dc.subjectBone Densityen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMusclesen
dc.subjectProstatic Neoplasmsen
dc.subjectZerbinis Publicationsen
dc.titleAdverse effects of androgen deprivation therapy in patients with prostate cancer: Focus on muscle and bone healthen
dc.typeotheren


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