Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium
dc.creator | Bahls M., Lorenz M.W., Dörr M., Gao L., Kitagawa K., Tuomainen T.-P., Agewall S., Berenson G., Catapano A.L., Norata G.D., Bots M.L., van Gilst W., Asselbergs F.W., Brouwers F.P., Uthoff H., Sander D., Poppert H., Hecht Olsen M., Empana J.P., Schminke U., Baldassarre D., Veglia F., Franco O.H., Kavousi M., de Groot E., Mathiesen E.B., Grigore L., Polak J.F., Rundek T., Stehouwer C.D.A., Skilton M.R., Hatzitolios A.I., Savopoulos C., Ntaios G., Plichart M., McLachlan S., Lind L., Willeit P., Steinmetz H., Desvarieux M., Ikram M.A., Johnsen S.H., Schmidt C., Willeit J., Ducimetiere P., Price J.F., Bergström G., Kauhanen J., Kiechl S., Sitzer M., Bickel H., Sacco R.L., Hofman A., Völzke H., Thompson S.G., on behalf of the PROG-IMT Study Group | en |
dc.date.accessioned | 2023-01-31T07:35:08Z | |
dc.date.available | 2023-01-31T07:35:08Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1177/2047487319877078 | |
dc.identifier.issn | 20474873 | |
dc.identifier.uri | http://hdl.handle.net/11615/71044 | |
dc.description.abstract | Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints. © The European Society of Cardiology 2019. | en |
dc.language.iso | en | en |
dc.source | European Journal of Preventive Cardiology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074338122&doi=10.1177%2f2047487319877078&partnerID=40&md5=95b45687f5d422be824befd827162604 | |
dc.subject | cholesterol | en |
dc.subject | high density lipoprotein cholesterol | en |
dc.subject | low density lipoprotein cholesterol | en |
dc.subject | biological marker | en |
dc.subject | cholesterol | en |
dc.subject | high density lipoprotein cholesterol | en |
dc.subject | low density lipoprotein cholesterol | en |
dc.subject | arterial wall thickness | en |
dc.subject | Article | en |
dc.subject | atherosclerosis | en |
dc.subject | cardiovascular disease | en |
dc.subject | cardiovascular disease assessment | en |
dc.subject | cardiovascular risk | en |
dc.subject | cerebrovascular accident | en |
dc.subject | cholesterol blood level | en |
dc.subject | disease exacerbation | en |
dc.subject | disease risk assessment | en |
dc.subject | follow up | en |
dc.subject | heart death | en |
dc.subject | heart infarction | en |
dc.subject | human | en |
dc.subject | meta analysis | en |
dc.subject | meta analysis (topic) | en |
dc.subject | priority journal | en |
dc.subject | prospective study | en |
dc.subject | risk assessment | en |
dc.subject | risk factor | en |
dc.subject | sensitivity analysis | en |
dc.subject | systolic blood pressure | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | blood | en |
dc.subject | blood pressure | en |
dc.subject | cardiovascular disease | en |
dc.subject | carotid artery disease | en |
dc.subject | cerebrovascular accident | en |
dc.subject | clinical trial | en |
dc.subject | diagnostic imaging | en |
dc.subject | disease exacerbation | en |
dc.subject | dyslipidemia | en |
dc.subject | female | en |
dc.subject | heart infarction | en |
dc.subject | hypertension | en |
dc.subject | male | en |
dc.subject | middle aged | en |
dc.subject | mortality | en |
dc.subject | multicenter study | en |
dc.subject | pathophysiology | en |
dc.subject | predictive value | en |
dc.subject | prognosis | en |
dc.subject | time factor | en |
dc.subject | very elderly | en |
dc.subject | young adult | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Biomarkers | en |
dc.subject | Blood Pressure | en |
dc.subject | Cardiovascular Diseases | en |
dc.subject | Carotid Artery Diseases | en |
dc.subject | Carotid Intima-Media Thickness | en |
dc.subject | Cholesterol | en |
dc.subject | Cholesterol, HDL | en |
dc.subject | Cholesterol, LDL | en |
dc.subject | Disease Progression | en |
dc.subject | Dyslipidemias | en |
dc.subject | Female | en |
dc.subject | Heart Disease Risk Factors | en |
dc.subject | Humans | en |
dc.subject | Hypertension | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Myocardial Infarction | en |
dc.subject | Predictive Value of Tests | en |
dc.subject | Prognosis | en |
dc.subject | Risk Assessment | en |
dc.subject | Stroke | en |
dc.subject | Time Factors | en |
dc.subject | Young Adult | en |
dc.subject | SAGE Publications Inc. | en |
dc.title | Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium | en |
dc.type | journalArticle | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |