It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis
Ημερομηνία
2019Γλώσσα
en
Λέξη-κλειδί
Επιτομή
Background There is concern that blood pressure (BP) lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis. We assessed the effect of glyceryl trinitrate (GTN) in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke (ENOS) Trial. Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP (140-220 mm Hg) to transdermal GTN or no GTN within 48 hours of onset. Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days. The primary outcome was the modified Rankin Scale (mRS) at day 90. Ipsilateral carotid stenosis was split: <30; 30-<50; 50-<70; ≥70. Data are ORs with 95 CIs adjusted for baseline prognostic factors. Results 2023 (60.5) ischaemic stroke participants had carotid imaging. As compared with <30, ≥70 ipsilateral stenosis was associated with an unfavourable shift in mRS (worse outcome) at 90 days (OR 1.88, 95 CI 1.44 to 2.44, p<0.001). Those with ≥70 stenosis who received GTN versus no GTN had a favourable shift in mRS (OR 0.56, 95 CI 0.34 to 0.93, p=0.024). In those with 50-<70 stenosis, continuing versus stopping prestroke antihypertensives was associated with worse disability, mood, quality of life and cognition at 90 days. Clinical outcomes did not differ across bilateral stenosis groups. Conclusions Following ischaemic stroke, severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days. GTN appears safe in ipsilateral or bilateral carotid stenosis, and might improve outcome in severe ipsilateral carotid stenosis. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Skeletal muscle relaxants in anaesthesiology
Benakis, A.; Plessas, C. T.; Plessas, S. T. (1999)During the 16th century, European explorers found that the Indians along the Amazon and Orinoco Rivers were using an arrow poison, named curare, that produced death by skeletal paralysis. Curare is one of several different ... -
Chios mastic gum: A plant-produced resin exhibiting numerous diverse pharmaceutical and biomedical prοperties
Dimas, K. S.; Pantazis, P.; Ramanujam, R. (2012)Chios mastic gum (CMG) is a resin produced by the plant Pistacia lentiscus var. chia. CMG is used to extract the mastic gum essential oil (MGO). CMG and MGO consist of nearly 70 constituents and have demonstrated numerous ... -
Drug-induced endocrinopathies and diabetes: A combo-endocrinology overview
Diamanti-Kandarakis E., Duntas L., Kanakis G.A., Kandaraki E., Karavitaki N., Kassi E., Livadas S., Mastorakos G., Migdalis I., Miras A.D., Nader S., Papalou O., Poladian R., Popovic V., Rachoń D., Tigas S., Tsigos C., Tsilchorozidou T., Tzotzas T., Bargiota A., Pfeifer M., on behalf of COMBO ENDO TEAM: 2018 (2019)In the currently overwhelming era of polypharmacy, the balance of the dynamic and delicate endocrine system can easily be disturbed by interfering pharmaceutical agents like medications. Drugs can cause endocrine abnormalities ...