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The role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention?

dc.creatorAloizou A.-M., Pateraki G., Siokas V., Mentis A.-F.A., Liampas I., Lazopoulos G., Kovatsi L., Mitsias P.D., Bogdanos D.P., Paterakis K., Dardiotis E.en
dc.date.accessioned2023-01-31T07:31:02Z
dc.date.available2023-01-31T07:31:02Z
dc.date.issued2020
dc.identifier10.1016/j.toxrep.2020.11.001
dc.identifier.issn22147500
dc.identifier.urihttp://hdl.handle.net/11615/70460
dc.description.abstractGliomas are the most common primary brain tumors in adults. They are generally very resistant to treatment and are therefore associated with negative outcomes. MicroRNAs (miRNAs) are small, non-coding RNA molecules that affect many cellular processes by regulating gene expression and, post-transcriptionally, the translation of mRNAs. MiRNA-21 has been consistently shown to be upregulated in glioma and research has shown that it is involved in a wide variety of biological pathways, promoting tumor cell survival and invasiveness. Furthermore, it has been implicated in resistance to treatment, both against chemotherapy and radiotherapy. In this review, we gathered the existent data on miRNA-21 and gliomas, in terms of its expression levels, association with grade and prognosis, the pathways it involves and its targets in glioma, and finally how it leads to treatment resistance. Furthermore, we discuss how this knowledge could be applied in clinical practice in the years to come. To our knowledge, this is the first review to assess in extent and depth the role of miRNA-21 in gliomas. © 2020en
dc.language.isoenen
dc.sourceToxicology Reportsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85096106197&doi=10.1016%2fj.toxrep.2020.11.001&partnerID=40&md5=b1c4883f9d2ac53683e32c95f6746997
dc.subjectapoptotic protease activating factor 1en
dc.subjectcaspase 3en
dc.subjectcyclin Den
dc.subjectcyclin D1en
dc.subjectDNA topoisomerase (ATP hydrolysing)en
dc.subjectdoxorubicinen
dc.subjectgalectin 1en
dc.subjectgelatinase Ben
dc.subjectgranzyme Ben
dc.subjecthyaluronic aciden
dc.subjectliposomeen
dc.subjectlomustineen
dc.subjectmicroRNAen
dc.subjectmicroRNA 21en
dc.subjectnimotuzumaben
dc.subjectpaclitaxelen
dc.subjectprotein Baxen
dc.subjectprotein p53en
dc.subjectsmall interfering RNAen
dc.subjecttemozolomideen
dc.subjectteniposideen
dc.subjecttranscription factor Sox2en
dc.subjecttumor necrosis factoren
dc.subjectvasculotropinen
dc.subjectangiogenesisen
dc.subjectanimal experimenten
dc.subjectapoptosisen
dc.subjectArticleen
dc.subjectastrocyteen
dc.subjectastrocytomaen
dc.subjectautismen
dc.subjectbioinformaticsen
dc.subjectblood brain barrieren
dc.subjectbrain canceren
dc.subjectbrain ischemiaen
dc.subjectbrain tumoren
dc.subjectcancer prognosisen
dc.subjectcancer surgeryen
dc.subjectcancer survivalen
dc.subjectcarcinogenesisen
dc.subjectcarcinogenicityen
dc.subjectcell differentiationen
dc.subjectcell invasionen
dc.subjectcell migrationen
dc.subjectcell proliferationen
dc.subjectcell survivalen
dc.subjectcell viabilityen
dc.subjectchemotherapyen
dc.subjectdisease free survivalen
dc.subjectDNA damageen
dc.subjectdrug delivery systemen
dc.subjectenzyme inhibitionen
dc.subjectexosomeen
dc.subjectexternal beam radiotherapyen
dc.subjectfluorescence in situ hybridizationen
dc.subjectgene overexpressionen
dc.subjectgenetic transcriptionen
dc.subjectglioblastomaen
dc.subjectgliomaen
dc.subjecthumanen
dc.subjecthypoxiaen
dc.subjectIC50en
dc.subjectinflammationen
dc.subjectlipophilicityen
dc.subjectMAPK signalingen
dc.subjectmelanomaen
dc.subjectmetastasisen
dc.subjectmicrogliaen
dc.subjectneural stem cellen
dc.subjectnonhumanen
dc.subjectnuclear magnetic resonance imagingen
dc.subjectnuclear reprogrammingen
dc.subjectovary canceren
dc.subjectoverall survivalen
dc.subjectoxidative stressen
dc.subjectpancreas canceren
dc.subjectprotein expressionen
dc.subjectprotein functionen
dc.subjectradiosensitivityen
dc.subjectradiosensitizationen
dc.subjectscientific literatureen
dc.subjectsignal transductionen
dc.subjecttumor cellen
dc.subjecttumor growthen
dc.subjecttumor invasionen
dc.subjecttumor suppressor geneen
dc.subjecttumor volumeen
dc.subjecttumor xenograften
dc.subjectupregulationen
dc.subjectElsevier Inc.en
dc.titleThe role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention?en
dc.typejournalArticleen


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