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Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies

dc.creatorZintzaras, E.en
dc.date.accessioned2015-11-23T10:55:06Z
dc.date.available2015-11-23T10:55:06Z
dc.date.issued2010
dc.identifier10.3109/13547500903297184
dc.identifier.issn1354-750X
dc.identifier.urihttp://hdl.handle.net/11615/34927
dc.description.abstractA synopsis and meta-analysis of studies that investigated the association between genetic variants involved in the homocysteine/folate metabolism pathway and risk of inflammatory bowel disease (IBD) were conducted. Four variants (MTHFR C6TTT, MTHFR A1298C, MTR A2756G and MTRR A66G) showed significant associations in individual studies. In meta-analyses, only the variant MTR A2756G indicated an association with the risk of IBD for the allele contrast and the dominant model (odds ratio (OR) 1.48 (1.12-1.97) and OR 1.55 (1.12-2.15), respectively). The effect sizes for Crohn's disease and ulcerative colitis were similar to IBD. Cumulative meta-analysis for C677T indicated a downward trend of association as information accumulates.</.en
dc.sourceBiomarkersen
dc.source.uri<Go to ISI>://WOS:000274855400008
dc.subjectInflammatory bowel diseaseen
dc.subjectCrohn's diseaseen
dc.subjectulcerative colitisen
dc.subjectMTHFRen
dc.subjectMTRen
dc.subjectMTRRen
dc.subjectTCN2en
dc.subjectCBSen
dc.subjecthomocysteineen
dc.subjectfolateen
dc.subjectgeneen
dc.subjectpolymorphismen
dc.subjectmeta-analysisen
dc.subjectMETHYLENETETRAHYDROFOLATE REDUCTASE GENEen
dc.subjectGENOME-WIDE ASSOCIATIONen
dc.subjectCROHNS-DISEASEen
dc.subjectNONSYNONYMOUS SNPSen
dc.subjectFOLATE-DEFICIENCYen
dc.subjectCONTROLLED-TRIALSen
dc.subjectSYNTHASE GENEen
dc.subjectPOLYMORPHISMSen
dc.subjectSUSCEPTIBILITYen
dc.subjectMUTATIONSen
dc.subjectBiotechnology & Applied Microbiologyen
dc.subjectToxicologyen
dc.titleGenetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studiesen
dc.typejournalArticleen


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