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The effect of dexamethasone on tissue fibrinolytic system in male and female rats
dc.creator | Tsantarliotou, M. | en |
dc.creator | Taitzoglou, I. | en |
dc.creator | Kokolis, N. | en |
dc.date.accessioned | 2015-11-23T10:50:50Z | |
dc.date.available | 2015-11-23T10:50:50Z | |
dc.date.issued | 1999 | |
dc.identifier.issn | 0258-851X | |
dc.identifier.uri | http://hdl.handle.net/11615/33797 | |
dc.description.abstract | Background: Dexamethasone in low and high doses affects blood fibrinolytic activity both in animals and humans. In this study the effect of a high dose of dexamethasone on plasminogen activator activity (PAA), t-PA antigen level, plasminogen activator inhibition (PAI) and plasmin inhibition (Pl) in rat heal?, brain, liver, lungs and kidneys was investigated in both sexes. Materials and Methods: Twenty male and twenty female adult Wistar rats were used. Dexamethasone was administered as a single intraperitoneal injection (3mg/kg/day) in rats, once daily, for a period of 5 consecutive days. t-PA antigen level was assayed by an enzyme-linked immunoabsorbant assay method PAA, PAI and PI were determined by spectrophotometric methods. The plasminogen used was isolated from I at plasma. Results: Dexamethasone induced variable changes in the fibrinolytic parameters in mt heart, brain and liver of both sexes; in lungs and kidneys dexamethasone had no effect. Conclusion: These changes of PAA, PAI and t-PA antigen level in heart, brain and liver induced by dexamethasone might be of importance regarding the involvement of glucocorticoids and plasminogen activators/plasmin in many pathophysiological conditions. | en |
dc.source.uri | <Go to ISI>://WOS:000080402400002 | |
dc.subject | dexamethasone | en |
dc.subject | plasminogen activator | en |
dc.subject | plasminogen activator inhibition | en |
dc.subject | plasmin inhibition | en |
dc.subject | tissue fibrinolysis | en |
dc.subject | PLASMINOGEN-ACTIVATOR ACTIVITY | en |
dc.subject | SEX-RELATED DIFFERENCES | en |
dc.subject | INDUCED | en |
dc.subject | INHIBITOR | en |
dc.subject | GENE-EXPRESSION | en |
dc.subject | HEPATOMA-CELLS | en |
dc.subject | GLUCOCORTICOIDS | en |
dc.subject | ORCHIECTOMY | en |
dc.subject | OVARIECTOMY | en |
dc.subject | UROKINASE | en |
dc.subject | BRAIN | en |
dc.subject | Medicine, Research & Experimental | en |
dc.title | The effect of dexamethasone on tissue fibrinolytic system in male and female rats | en |
dc.type | journalArticle | en |
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