dc.creator | Tagarakis, G. I. | en |
dc.creator | Tsolaki-Tagaraki, F. | en |
dc.creator | Tsolaki, M. | en |
dc.creator | Diegeler, A. | en |
dc.creator | Kazis, D. | en |
dc.creator | Rouska, E. | en |
dc.creator | Papassotiropoulos, A. | en |
dc.date.accessioned | 2015-11-23T10:49:25Z | |
dc.date.available | 2015-11-23T10:49:25Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1007/s00392-007-0539-3 | |
dc.identifier.issn | 1861-0684 | |
dc.identifier.uri | http://hdl.handle.net/11615/33545 | |
dc.description.abstract | Background Cognitive decline (CD) and delirium (PD) are commonly observed complications after bypass heart surgery. In this study we aimed to investigate whether certain genetic factors (alleles of the SOAT-1 gene) play a role in their appearance. Patients and methods We examined 137 patients receiving coronary bypass surgery with a neuropsychiatric test battery consisting of the Mini Mental State Examination (MMSE), the Brief Psychiatric Rating Scale (BPRS), the Wechsler's Memory Scale-Revised (WMS-R) on admission and one month after surgery, and the Delirium Rating Scale postoperatively, when indicated, and genotyped them in relation to the SOAT-1 genotypes (AA positive group with augmented protection of the nerve cells against stress and the AA negative group - AC and CC subgroups - with diminished protection against stress). Results We noted a significant decline in test results postoperatively and a high frequency of delirium (29.92% of the patients). None of these complications could be associated to the SOAT-1 genotypes. Conclusions Our study confirmed the expected cognitive decline and highly frequent delirium after bypass heart surgery and excluded the possible role of SOAT-1 genotype polymorphisms in their genesis. | en |
dc.source.uri | <Go to ISI>://WOS:000249258500003 | |
dc.subject | CABG (coronary artery bypass grafting) | en |
dc.subject | cognitive decline | en |
dc.subject | postoperative | en |
dc.subject | delirium | en |
dc.subject | genetic polymorphisms | en |
dc.subject | neuropsychiatric battery | en |
dc.subject | A-CHOLESTEROL ACYLTRANSFERASE | en |
dc.subject | ALZHEIMERS-DISEASE | en |
dc.subject | CARDIAC OPERATION | en |
dc.subject | GRAFT-SURGERY | en |
dc.subject | RATING-SCALE | en |
dc.subject | RISK | en |
dc.subject | ASSOCIATION | en |
dc.subject | Cardiac & Cardiovascular Systems | en |
dc.title | The role of SOAT-1 polymorphisms in cognitive decline and delirium after bypass heart surgery | en |
dc.type | journalArticle | en |